Patents Assigned to Duphar International Research B.V.
-
Patent number: 4920135Abstract: Certain organic compounds derived from urea or thiourea having insecticidal activity and methods of their preparation are disclosed. The compounds according to the invention have been found to interfere with the mechanism of metamorphoses which occurs in insects. Hence, the substances according to the invention are specifically active against insects. Owing to this specificity and because of the absence of phytotoxicity effects, the compounds of this invention are of prime importance.Type: GrantFiled: February 7, 1989Date of Patent: April 24, 1990Assignee: Duphar International Research B.V.Inventors: Kobus Wellinga, Rudolf Wulder
-
Patent number: 4889849Abstract: The invention relates to new spasmolytically active tertiary amine derivatives and the salts thereof, of the formula (1) ##STR1## wherein the symbols have the following meanings: .circle.A is phenyl, or a 5- or 6-membered aromatic group containing 1 or 2 of the following hetero atoms: oxygen and/or sulphur and/or nitrogen;R.sub.1 and R.sub.2 may be equal or different and are hydrogen or substituents;R.sub.3 is a hydrogen atom or, together with R.sub.4, may form a ring consisting of 6 or 7 carbon atoms;R.sub.4 is a hydrogen atom or alkyl group having 1-3 carbon atoms;R.sub.5 is a straight, branched or cyclic alkyl group having 1-4 carbon atoms;R.sub.6 is a straight or branched, saturated or unsaturated alkylene group having a chain length of 2-6 carbon atoms;Z is the group NR.sub.12, wherein R.sub.12 is a hydrogen atom or an alkyl group having 1-3 carbon atoms, or Z is an oxygen atom;n has the value 0 or 1;X is a carbonyl group, thiocarbonyl group or SO.sub.2 group;R.sub.7 and R.sub.Type: GrantFiled: January 9, 1989Date of Patent: December 26, 1989Assignee: Duphar International Research B.V.Inventors: Ineke Van Wijngaarden, Johannes M. A. Zwagemakers, Jan Van Dijk
-
Patent number: 4889863Abstract: The invention relates to new thiazole compounds of the general formula ##STR1## wherein R is an C.sub.1 -C.sub.12 alkyl group or a phenyl group, which groups are unsubstituted or substituted with halogen, nitro or cyano;R.sub.1 is a cyano group; a formyl group; an alkylcarbonyl or alkoxycarbonyl group having 2-5 carbon atoms; or a substituted or non-substituted benzoyl group;R.sub.2 is a hydrogen atom; a halogen atom; an amino group; an amino group substituted with 1 or 2 substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.5 alkynyl, C.sub.2 -C.sub.5 alkylcarbonyl and C.sub.2 -C.sub.5 alkoxycarbonyl; an alkyl, alkoxy, alkylthio, alkylsulphinyl or alkyl-sulphonyl group having 1-4 carbon atoms; or a substituted or non-substituted aryl, aryloxy, arylthio, arylsulphinyl or arylsulphonyl group; andn is 1 or 2.The new compounds show a fungicidal activity and may be used in particular against plant pathogenic seed fungi and soil fungi.Type: GrantFiled: July 22, 1988Date of Patent: December 26, 1989Assignee: Duphar International Research B.V.Inventors: Hendrik Dolman, Johannes Kuipers
-
Patent number: 4889852Abstract: It has been found that a group of piperazine derivatives known to have blood-pressure lowering properties possess good anxiolytic properties. In two well known animal test models the compounds are active when used intraperitoneally in dosages of 0.3 mg/kg.Type: GrantFiled: September 7, 1988Date of Patent: December 26, 1989Assignee: Duphar International Research B.V.Inventors: Jan Hartog, Johannes Mos
-
Patent number: 4874770Abstract: The invention relates to new aryl-substituted (N-piperidinyl)methyl- and (N-piperazinyl)methylazoles having interesting pharmacological, notably antipsychotic, properties.The compounds may be prepared in a manner known for the synthesis of analogous compounds and be processed to compositions according to known methods.Type: GrantFiled: July 1, 1988Date of Patent: October 17, 1989Assignee: Duphar International Research B.V.Inventors: Ineke Van Wijngaarden, Cornelis Kruse, Johannes A. M. Van Der Heyden, Martinus T. M. Tulp
-
Patent number: 4854961Abstract: The invention relates to a herbicidally and/or algicidally active compound of the general formula ##STR1## wherein R.sub.1 is a substituted or non-substituted alkyl group having 1-6 carbon atoms, or an alkenyl or alkynyl group having 2-6 carbon atoms;R.sub.2 is a halogen atom; a nitro group; a cyano group; a substituted or non-substituted benzyl, phenyl, phenoxy, phenylthio, phenylsulphinyl, phenylsulphonyl or phenylsulphonyloxy group; or a halogenated or non-halogenated alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl or alkylsulphonyloxy group having 1-4 carbon atoms;R.sub.3 is a hydrogen atom, a halogen atom, or an alkyl group having 1-4 carbon atoms; andX is O or S;or a salt of this compound with an organic or inorganic acid.Type: GrantFiled: October 30, 1987Date of Patent: August 8, 1989Assignee: Duphar International Research B.V.Inventors: Kobus Wellinga, Jacobus H. H. Eussen
-
Patent number: 4844908Abstract: Clovoxamine, i.e., 4'-chloro-5-methoxyvalerophenone-O-(2-aminoethyl)oxime is a known compound having antidepressive activity. The fumarate (1:1) of clovoxamine may be administered orally in the form of tablets.Type: GrantFiled: November 23, 1987Date of Patent: July 4, 1989Assignee: Duphar International Research B.V.Inventors: Hendrik Duinker, Hugo Bijl
-
Patent number: 4833151Abstract: Certain organic compounds derived from urea or thio-urea having insectical activity and methods of their preparation are disclosed. The compounds according to the invention have been found to interfere with the mechanism of metamorphoses which occurs in insects. Hence, the substances according to the invention are specifically active against insects. Owing to this specificity and because of the absence of phytotoxicity effects, the compounds of this invention are of prime importance.Type: GrantFiled: May 28, 1986Date of Patent: May 23, 1989Assignee: Duphar International Research B.V.Inventors: Kobus Wellinga, Rudolf Mulder
-
Patent number: 4833142Abstract: Blood-pressure lowering compounds having a structure as shown in the accompanying formula sheets.Type: GrantFiled: November 9, 1987Date of Patent: May 23, 1989Assignee: Duphar International Research B.V.Inventors: Jan Hartog, Wouter Wouters, Lneke van Wijngaarden
-
Patent number: 4822340Abstract: An automatic injector for injecting one or more different injection liquids, comprising a combination of a substantially cylindrical means containing a discharge mechanism and a plurality of cartridge elements. The cartridge elements comprise a piston in the substantially cylindrical means, a sealing stopper, a number of separating stoppers equal to one less than the number of the liquids, and a needle holder with injection needle. The needle holder comprises a stopper that is movable in the substantially cylindrical means and comprises a longitudinal bore. The injector comprises a by-pass means for injection liquid in front of the sealing stopper.Type: GrantFiled: October 9, 1986Date of Patent: April 18, 1989Assignee: Duphar International Research B.V.Inventor: Paulus R. Kamstra
-
Patent number: 4820286Abstract: The invention relates to an automatic injector for injecting one or more injection liquids, comprising an assembly of a discharge mechanism, a cartridge in a cartridge holder, and an outer sleeve which is telescopically slidable around the cartridge holder, which cartridge comprises a barrel, in the barrel a piston and a number of separating stoppers equal to one less than the number of injection liquids, a needle holder with injection needle and optionally a by-pass for injection liquid. The injector is suitable for accommodating a solid and a solvent therefor, and for that purpose comprises a passable stopper between solid and solvent and a solvent by-pass in the barrel wall or in the passable stopper, in which, by a single or repeated operation of telescoping external parts of the injector solvent can pass the passable stopper and can reach the solid, as a result of which the injector can be made ready for use.Type: GrantFiled: May 12, 1987Date of Patent: April 11, 1989Assignee: Duphar International Research B.V.Inventor: Gillis P. van der Wal
-
Patent number: 4801012Abstract: The invention relates to a holder for a plurality of disposable syringes, the syringes comprising a barrel, a needle connection means on the front end of the barrel, in which or to which an injection needle is or can be sealingly connected, and a finger grip, provided with an outwardly projecting flange and optionally with a clamping sleeve for a clamping connection around the rear open end of the barrel. The holder comprises a strip of flexible material one side of which comprises a number of resilient projections, distributed over the surface, for a detachable connection of the syringes in such a way that the rear end of the barrel or the rear face of the finger grip adjoins the surface of the strip in a non-sealing manner.Type: GrantFiled: July 7, 1987Date of Patent: January 31, 1989Assignee: Duphar International Research B.V.Inventors: Johannes E. Steenhuisen, Gerrit Grotenhuis
-
Patent number: 4798671Abstract: The invention relates to a device for taking liquid from a reservoir by inward suction with simultaneous filtration, comprising a flexible tube having at one end a filtering unit, which can be immersed in the liquid through an opening in the reservoir, and having a mouthpiece at its other end. The mouthpiece is connected to the tube in a sealing manner via a flexible hollow member which forms an internal connection between tube and mouthpiece, and before use of the device the mouthpiece may be enveloped hygienically by a detachable protective cap.Type: GrantFiled: March 24, 1987Date of Patent: January 17, 1989Assignee: Duphar International Research B.V.Inventors: Jan W. M. Mijers, Johannes E. Steenhuisen
-
Patent number: 4792329Abstract: The invention relates to a multi-compartment syringe comprising an ampoule having a plunger, a sealing stopper and at least one separating stopper between the plunger and the sealing stopper, and a needle holder consisting of a collar, a neck for an injection needle, a shaft between the collar and the neck and a by-pass means in the inner wall of the shaft, the space in the shaft of the needle holder being at least slightly longer than the sealing stopper, the ampoule wall comprising a liquid by-pass means through which the liquid behind the separating stopper or stoppers can reach the substance in front of the separating stopper or front separating stopper and can mix with same or can dissolve it, the ampoule, before use of the syringe, comprising an empty space in front of the sealing stopper.Type: GrantFiled: June 24, 1986Date of Patent: December 20, 1988Assignee: Duphar International Research B.V.Inventor: Johan C. Schreuder
-
Patent number: 4791132Abstract: The invention relates to a group of new phenyl, pyrrolidin-2-yl substituted 5-ring heterocyclic compounds of the formula ##STR1## wherein A is an unsaturated heterocyclic 5-ring having at least one nitrogen or oxygen atom in the ring, with the proviso that the phenyl substituent is in a meta-position with respect to the 2-pyrrolidinyl substituent.The compounds have interesting pharmacological, notably antipsychotic properties.Type: GrantFiled: September 9, 1987Date of Patent: December 13, 1988Assignee: Duphar International Research B.V.Inventors: Ineke Van Wijngaarden, Cornelis G. Kruse, Roelof Van Hes, Johannes A. M. Van Der Heyden
-
Patent number: 4783485Abstract: The invention relates to new benzoylurea compounds having insecticidal and acaricidal activity, of the general formula ##STR1## wherein R.sub.1 is a hydrogen atom or represents 1 or 2 halogen atoms;Ar is a para-phenylene group or a para-pyridylene group, which groups may be substituted with 1 or 2 substituents selected from the group consisting of chlorine, methyl and trifluoromethyl;B is an oxygen atom or represents a group having the formula ##STR2## wherein R.sub.Type: GrantFiled: September 26, 1986Date of Patent: November 8, 1988Assignee: Duphar International Research B.V.Inventors: Marius S. Brouwer, Arnoldus C. Grosscurt, Roelof Van Hes
-
Patent number: 4782061Abstract: The invention relates to a group of new bicyclic heteroarylpiperazine derivatives of formula 1. It was found that these compounds have interesting psychotropic in particular anti-psychotic properties.The compounds can be prepared according to methods known for the synthesis of analogous compounds.Type: GrantFiled: December 18, 1985Date of Patent: November 1, 1988Assignee: Duphar International Research B.V.Inventors: Cornelis G. Kruse, Johannes A. M. van der Heyden, Ineke van Wijngaarden, Jan Hartog, Berend Olivier
-
Patent number: 4772604Abstract: The invention relates to new aryl-substituted (N-piperidinyl)methyl- and (N-piperazinyl)methylazoles having interesting pharmacological, notably antipsychotic, properties.The compounds may be prepared in a manner known for the synthesis of analogous compounds and be processed to compositions according to known methods.Type: GrantFiled: February 24, 1987Date of Patent: September 20, 1988Assignee: Duphar International Research B.V.Inventors: Ineke van Wijngaarden, Cornelis G. Kruse, Johannes A. M. van der Heyden, Martinus T. M. Tulp
-
Patent number: 4710516Abstract: The invention relates to an insecticidal and acaricidal composition comprising a benzoylurea compound of the general formula ##STR1## wherein R.sub.1 is a halogen atom,R.sub.2 is a hydrogen atom, a methoxy group or a halogen atom,R.sub.3 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of halogen, methyl and trifluoromethyl,R.sub.4 is a hydrogen atom or represents 1-3 substituents which are selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkyl and C.sub.1 -C.sub.4 haloalkoxy,X is an oxygen atom or a sulphur atom,n is 0 or 1, andR.sub.5 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.2 -C.sub.6 alkenyl group or a C.sub.3 -C.sub.6 cycloalkyl group,with the proviso, that, if n is 0 and R.sub.5 is a hydrogen atom, R.sub.3 is a hydrogen atom.The composition may be used for the control of insects and/or mites in a dosage of 1 to 5,000 grams of active substance per hectare.Type: GrantFiled: November 19, 1986Date of Patent: December 1, 1987Assignee: Duphar International Research B.V.Inventors: Marius S. Brouwer, Arnoldus C. Grosscurt
-
Patent number: 4697428Abstract: The invention relates to a device for concentrating solutions by partly freezing-out solvent, consisting of a vessel surrounded laterally by an insulated cooling jacket, the vessel comprising a stirring means and a draining aperture at the bottom. The cooling jacket does not extend down to the lowermost portion of the vessel. The lowermost portion of the vessel in which the stirring means and the draining aperture are accommodated, externally comprises, preferably is surrounded by, a heating medium.Type: GrantFiled: March 20, 1986Date of Patent: October 6, 1987Assignee: Duphar International Research B.V.Inventors: Henri M. Ruijten, Hans De Bree, Peter H. Van Amsterdam