Patents Assigned to E. R. Squibbs & Sons, Inc.
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Publication number: 20060276763Abstract: The ostomy system with mounting wafer and repositionable pouch includes a resealable tape provided on one of the system members and a releasable film provided on the other system member. In a preferred embodiment of the invention the resealable tape is located on a faceplate of the pouch and the releasable film is located on the body-side mounting wafer. The pouch is thus secured to the body-side mounting wafer by engaging the resealable tape with the releasable film. The resealable tape and the releasable film coupling arrangement permit repeated removal of the pouch from the body-side mounting wafer and repeated resecurement of the pouch to the mounting wafer. The pouch can thus be repositioned relative to the mounting wafer even after the pouch has been worn for a day.Type: ApplicationFiled: July 25, 2006Publication date: December 7, 2006Applicant: E.R. SQUIBB & SONS. INC.Inventor: Denis Keyes
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Patent number: 6630502Abstract: A method is provided for slowing the progression of atherosclerosis in hypertensive or normotensive patients and reducing or eliminating atherosclerotic lesions in such patients by administering a combination of a cholesterol lowering drug such as pravastatin, and an ACE inhibitor, especially one containing a mercapto moiety, such as captopril or zofenopril.Type: GrantFiled: December 2, 1991Date of Patent: October 7, 2003Assignee: E.R. Squibb & Sons, Inc.Inventors: James L. Bergey, Werner Tschollar, Cary S. Yonce, James C. Kawano
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Publication number: 20030181737Abstract: A method for extracting taxanes such as taxol, comprising the use of supercritical fluids.Type: ApplicationFiled: April 18, 2003Publication date: September 25, 2003Applicant: E.R. Squibb & Sons, Inc.Inventor: Jayaprakash B. Nair
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Patent number: 6602232Abstract: The ostomy system with mounting wafer and repositionable pouch includes a resealable tape provided on one of the system members and a releasable film provided on the other system member. In a preferred embodiment of the invention the resealable tape is located on a faceplate of the pouch and the releasable film is located on the body-side mounting wafer. The pouch is thus secured to the body-side mounting wafer by engaging the resealable tape with the releasable film. The resealable tape and the releasable film coupling arrangement permit repeated removal of the pouch from the body-side mounting wafer and repeated resecurement of the pouch to the mounting wafer. The pouch can thus be repositioned relative to the mounting wafer even after the pouch has been worn for a day.Type: GrantFiled: February 17, 1995Date of Patent: August 5, 2003Assignee: E.R. Squibb & Sons, Inc.Inventor: Denis E. Keyes
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Patent number: 6551794Abstract: Stable compositions containing biotinylated molecules, such as enzymes, are provided. The compositions include a biotinylated biomolecule, a biomolecule protectant, a buffer, a bulking agent selected from one or more water soluble, nonionic polymers and preferably a terminal sterilization protectant. The compositions can be utilized either as aqueous solutions or preferably in dried form, e.g., as a lyophilized, powder cake. They have applicability in any case where avidin/biotin technology is used and are particularly important as compositions containing a thrombin-like enzyme, e.g., for preparation of a fibrin monomer and fibrin monomer-based fibrin sealants.Type: GrantFiled: November 9, 1995Date of Patent: April 22, 2003Assignee: E. R. Squibb & Sons, Inc.Inventors: Steven James Burton, James C. Pearson, Peter A. D. Edwardson, Alan Menzies
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Patent number: 6416971Abstract: Soluble, single chain T cell receptors, nucleic acid sequences, particularly DNA sequences, encoding the soluble, single chain T cell receptor, expression vectors containing the DNA sequences, and host cells containing the expression vectors.Type: GrantFiled: May 8, 1991Date of Patent: July 9, 2002Assignees: E.R. Squibb & Sons, Inc., Dana Farber Cancer InstituteInventors: Ellis L. Reinherz, Jiri Novotny, Stephen T. Smiley, Ping Li, Ramesh Ganju
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Patent number: 6387082Abstract: An ostomy appliance or wound drainage device having a receptacle side component including a receptacle for receiving and storing waste solids and fluids and a bodyside component for adhering to the patient's skin around the stoma in which the two components are releasably sealed together through a pealable, washable based coupling mechanism.Type: GrantFiled: September 1, 1999Date of Patent: May 14, 2002Assignee: E. R. Squibb & Sons, Inc.Inventor: Frank Freeman
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Patent number: 6284285Abstract: A method for isolating tissue repair promoting substances from human or animal blood, which method comprises collecting the human or animal blood from a single human or animal individual in a first container of a container system comprising at least first and second interconnected containers; centrifuging the container system containing said blood so as to separate the blood in various fractions including a plasma fraction; transferring at least part of the plasma fraction to said second container of the container system; subjecting the plasma fraction in said second container to a low temperature so as to obtain a precipitate comprising tissue repair promoting substances; concentrating said precipitate in said second container so as to obtain a first fraction comprising a major part of the non-precipitated material, and a second fraction comprising at least the major part of the precipitate and a minor part of the non-precipitated material; and separating said second fraction comprising the tissue repair proType: GrantFiled: December 29, 1992Date of Patent: September 4, 2001Assignee: E. R. Squibb & Sons, Inc.Inventor: Ulla Sivertsen Weis-Fogh
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Patent number: 6187752Abstract: A method is provided for treating schizophrenia in a mammalian species by administering an ACE inhibitor, such as captopril, alone or with a neuroleptic such as cholecystokinin, fluphenazine or haloperidol.Type: GrantFiled: September 12, 1991Date of Patent: February 13, 2001Assignee: E.R. Squibb & Sons, Inc.Inventors: Abraham Sudilovsky, Joram Feldon, Ina Weiner, A. David Smith, John N. P. Rawlins
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Patent number: 6117885Abstract: Compounds of the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, A, B, D and E are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.Type: GrantFiled: February 24, 1994Date of Patent: September 12, 2000Assignee: E. R. Squibb & Sons, Inc.Inventors: Denis Evan Ryono, John Lloyd
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Patent number: 6087349Abstract: A method is provided by blocking or preventing the prenylation of CAAX box containing proteins including ras oncogene products thereby preventing and/or treating ras-related tumors which includes the step of administering a therapeutically effective amount of a protein-prenyl transferase inhibitor.Type: GrantFiled: May 6, 1998Date of Patent: July 11, 2000Assignee: E. R. Squibb & Sons, Inc.Inventors: Scott A. Biller, Mariano Barbacid, Eric M. Gordon, David R. Magnin, Chester A. Meyers, Veeraswamy Manne
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Patent number: 6066773Abstract: A thin film device for medical applications such as a wound dressing including an occlusive layer having an edge portion about at least a portion of the thin film device and a non-continuous, hydrocolloid-containing polymeric support layer overlying the edge portion of the occlusive layer.Type: GrantFiled: August 25, 1995Date of Patent: May 23, 2000Assignee: E. R. Squibb & Sons, Inc.Inventor: Frank Freeman
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Patent number: 6046024Abstract: Compositions and methods for avidin immobilized on an inert support material, e.g. agarose, are disclosed. The compositions have high activity levels of avidin and may further include a bulking agent, e.g., maltose, and a protectant to maintain the stability and integrity of the avidin agarose during lyophilization and terminal sterilization processes. These compositions have applicability in any instance where avidin agarose and/or the avidin/biotin technology are useful. In particular, the present compositions are useful in an enzyme capture system to prepare fibrin monomer useful for fibrin sealants. The fibrin is prepared by subjecting a fibrinogen-containing composition to a biotinylated enzyme to convert the fibrinogen in the composition to a corresponding fibrin monomer. A fibrin monomer/biotinylated enzyme mixture is formed.Type: GrantFiled: August 1, 1997Date of Patent: April 4, 2000Assignee: E. R. Squibb & Sons, Inc.Inventors: Steven James Burton, James C. Pearson, Peter A. D. Edwardson
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Patent number: 6031149Abstract: The present invention provides mice which are deficient in the normal expression of one or more members of the RAR or RXR class of receptors, to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous or homozygous for such deficiency. The present invention further provides the use of any of the above mice and cell lines in situations where the absence of at least one RAR or RXR receptors, or the normal expression thereof, is desirable.Type: GrantFiled: December 29, 1995Date of Patent: February 29, 2000Assignees: Institut National De La Sante Et De La Recherche Medicale, Centre National De La Recherche Scientifique, Universite Louis Pasteur, E.R. Squibb & Sons, Inc.Inventors: Pierre Chambon, Thomas Lufkin, David Lohnes, Manuel Mark, Andree Dierich, Philippe Gorry, Philippe Kastner, Marianne Lemeur, Cathy Mendelsohn
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Patent number: 6030794Abstract: The present invention provides mice which are deficient in the normal expression of one or more members of the RAR or RXR class of receptors, mice which are heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous or homozygous for such deficiency. The present invention further provides the use of any of the above mice and cell lines in situations where the absence of at least one RAR or RXR receptor(s), or the normal expression thereof, is desirable.Type: GrantFiled: June 27, 1995Date of Patent: February 29, 2000Assignees: Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Universite Louis Pasteur, E. R. Squibb & Sons, Inc.Inventors: Pierre Chambon, Thomas Lufkin, David Lohnes, Manuel Mark, Andree Dierich, Philippe Gorry, Philippe Kastner, Marianne Lemeur, Cathy Mendelsohn
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Patent number: 5998155Abstract: Compositions and methods for avidin or protein having affinity for biotin immobilized on an inert support material, e.g., agarose, are disclosed. The compositions have high activity levels for binding biotin and may include a bulking agent, e.g., maltose, and a protectant to maintain the stability and integrity of the composition during lyophilization and terminal sterilization processes. The compositions have applicability in any instance where avidin agarose and/or the avidin/biotin technology are useful. In particular, the present compositions are useful in an enzyme capture system to prepare fibrin monomers useful for fibrin sealants.Type: GrantFiled: August 1, 1997Date of Patent: December 7, 1999Assignee: E.R. Squibb & Sons, Inc.Inventors: Steven James Burton, James C. Pearson, Peter A. D. Edwardson
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Patent number: 5986095Abstract: A process is described for preparing a compound of the formula or the S-enantiomer thereof,wherein:R is alkyl, aryl, cycloalkyl, aralkyl, or cycloalkylalkyl,R.sup.1 is halogen;R.sup.2 is halogen, alkyl, cycloalkyl, aryl or ##STR1## wherein the process comprises treating the associated racemic alcohol with an acylatingagent ##STR2## (wherein L is a leaving group) and an enzyme or microorganism capable of enantioselective acylation. This process may also be used to isolate the unreacted R- or S-alcohol. The acylated product may be enantioselectively hydrolyzed with a lipase or lipase-supplying microorganism to the S- or R-alcohol. Compounds prepared by this invention are useful antipsychotic agents or useful intermediates therefor.Type: GrantFiled: January 6, 1992Date of Patent: November 16, 1999Assignee: E.R. Squibb & Sons, Inc.Inventors: Ronald L. Hanson, Ramesh N. Patel, Laszlo J. Szarka
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Patent number: 5968024Abstract: An ostomy appliance or wound drainage device having a lower end with an adhesive composition thereon so that when the lower end is folded upon itself, the drainage opening is closed off, or, alternatively, the lower end is made of a material having intrinsic adhesive properties.Type: GrantFiled: February 24, 1998Date of Patent: October 19, 1999Assignee: E. R. Squibb & Sons, Inc.Inventor: Frank Freeman
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Patent number: 5964485Abstract: A tube coupling is shown, particularly but not exclusively intended for use in joining tubes which have medical and surgical uses. A coupling according to the invention may be used to connect an ostomy bag to a drainage tube, or to connect an incontinence urine collection device to a drainage tube, or to connect a drainage tube to a drainage bag, or a catheter to a drainage tube. A tube coupling has a male part and a female part. The former has a radially extending external peripheral rib near its free end. The female part is made in one piece and comprises a tubular shell of a relatively rigid plastics material provided with an annular internal recess. The recess has molded therein a hollow tubular member of a relatively soft plastics material. The female part has no loose parts to become detached, can be made inexpensively by a "two-shot" molding process, and provides extremely good security against leakage.Type: GrantFiled: July 10, 1996Date of Patent: October 12, 1999Assignee: E.R. Squibb & Sons, Inc.Inventors: David R. Hame, Howard Barratt
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Patent number: 5951533Abstract: An ostomy appliance or wound drainage device having a receptacle side component including a receptacle for receiving and storing waste solids and fluids and a bodyside component for adhering to the patient's skin around the stoma in which the two components are releasably sealed together through a pealable, washable based coupling mechanism.Type: GrantFiled: July 26, 1995Date of Patent: September 14, 1999Assignee: E.R. Squibb & Sons, IncInventor: Frank Freeman