Patents Assigned to East China University of Science and Technology
  • Patent number: 11555860
    Abstract: A method for testing a mechanical performance of a lithium ion battery electrode based on a nano-indentation technology includes following steps: connecting an assembled lithium ion battery with an electrochemical test device and setting different test working conditions, so that cyclic charge and discharge experiments are performed on the battery to obtain an attenuation curve of a battery capacity; disassembling the battery and taking out the electrode; scraping some powder from a surface of the cyclic electrode plate and an initial uncyclic electrode plate, and laying down the powder in cold mounting molds separately, pouring the cold mounting solution into the molds; taking out the samples from the molds respectively after the liquid is completely cured and cooled; detecting a mechanical performance after polishing the samples surfaces and analyzing the mechanical performance decay rule of the electrodes.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: January 17, 2023
    Assignee: East China University of Science and Technology
    Inventors: Weiling Luan, Ying Chen, Senming Wu, Haofeng Chen
  • Publication number: 20220410108
    Abstract: The present application discloses a multi-region plasma shell-and-tube reactor comprising a shell body. At least two reaction regions are provided inside the shell body, and a horizontal separation panel is provided between any two adjacent reaction regions, used to separate the two and passing through the tubes. A central hole is provided in the center of any horizontal separation panel, and at least one auxiliary hole distributed around the central axis of the central hole is provided in any horizontal separation panel so as to cooperate with the central hole to cause a vortex state to be formed in a reaction region.
    Type: Application
    Filed: November 23, 2020
    Publication date: December 29, 2022
    Applicants: ZHEJIANG WYNCA CHEMICAL INDUSTRY GROUP CO., LTD, EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Zhenmin CHENG, Shengbao JIANG, Shenluan YU, Shuguang ZHOU, Minhai TU, Long QIN, Zhichao JIN, Zibin HUANG, Meichen CHEN, Peiqing YUAN
  • Patent number: 11534427
    Abstract: The present invention relates to applications of a novel thiazole derivative in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: December 27, 2022
    Assignee: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Honglin Li, Zhenjiang Zhao, Rui Wang, Yufang Xu, Wanqi Wang, Yingfang Yang
  • Publication number: 20220335443
    Abstract: The present disclosure discloses a novel multi-stable and erasable anti-counterfeiting technology with controlled reflection color and the application thereof in optical coding. The method and use are characterized by high thermal stability and robust fatigue resistance, and the realization thereof relies on the material system composed of an intrinsic chiral diarylethene molecule based on steric hindrance ethene bridge and a liquid crystal (LC) material disclosed herein.
    Type: Application
    Filed: October 12, 2020
    Publication date: October 20, 2022
    Applicants: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY, SUZHOU KUNHUANG NEW MATERIAL TECHNOLOGY CO.,LTD.
    Inventors: Weihong Zhu, Zhigang Zheng, Huijun Li, Honglong HU
  • Patent number: 11464795
    Abstract: Provided are use of a saponin compound of formula (I) or (II), or a pharmaceutically acceptable salt, prodrug or solvate thereof, in the manufacture of a medicament targeting PD-1. The medicament targeting PD-1 is one which treats a disease by inhibiting PD-1 from binding to a ligand thereof. The disease may be a tumor, an infection caused by a bacterium, a virus or a fungus, or an inflammatory disease.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: October 11, 2022
    Assignees: East China University Of Science And Technology, Yunnan University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Honglin Li, Weilie Xiao, Lili Zhu, Lina Quan, Qiao Li, Yanyan Diao, Zhenjiang Zhao, Hualiang Jiang
  • Publication number: 20220275282
    Abstract: A method and apparatus for hydrocracking mineralized refuse pyrolysis oil. The method may use the following steps: (a) crushing and pyrolyzing mineralized refuse to obtain arene and alkane precursor biomass oil; (b) hydrogenating the arene and alkane precursor biomass oil obtained in step (a), and separating the obtained hydrocrackate to obtain arene and alkane; and (c) purifying, recovering and optimizing the arene and alkane obtained in step (b), and performing deep processing to produce naphtha, jet fuel, light diesel oil, and heavy diesel oil.
    Type: Application
    Filed: June 16, 2020
    Publication date: September 1, 2022
    Applicant: East China University of Science and Technology
    Inventors: Yulong CHANG, Hualin WANG, Xia JIANG, Jianping LI, Jingyi ZHU, Pengbo FU, Wei YUAN
  • Publication number: 20220226539
    Abstract: The present disclosure relates to a composite scaffold containing DFO and rhBMP-2 capable of synergistically stimulating bone formation, a preparation method and use thereof. The composite scaffold contains a matrix, a PEGS gel layer and rhBMP-2, wherein the matrix is an MBG scaffold grafted with DFO on the surface, the PEGS gel layer is carried on the surface of the matrix, and rhBMP-2 is carried inside the PEGS gel layer. In the present disclosure, the function of DFO and rhBMP-2 in vivo and in vitro can be regulated by precisely controlling the immobilization mode and spatial distribution of DFO and rhBMP-2 in the scaffold, and the all-round repair of “rapid enrichment of target cells—angiogenesis-guided bone” can be achieved.
    Type: Application
    Filed: March 12, 2021
    Publication date: July 21, 2022
    Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Yuan YUAN, Haoyi NIU, Hua HONG, Yongsheng LI, Lili SUN
  • Patent number: 11384036
    Abstract: Disclosed is a method for preparing aromatic hydrocarbons by hydrocracking a polymer containing aromatic rings, which includes reacting the polymer fragment with hydrogen under the action of a catalyst at a temperature of no more than 350° C.; separating a reaction product to obtain the aromatic hydrocarbons. The catalyst comprises a carrier and an active ingredient supported on the carrier, the active ingredient is at least one selected from Ru, Rh, Pt, Pd, Fe, Ni, Cu and Co, the carrier is at least one selected from metal oxide, phosphate, molecular sieve, SiO2 and sulfonated carbon, the metal oxide is at least one selected from Al2O3, Nb2O5, Nb2O5—Al2O3, Nb2O5—SiO2, TiO2, ZrO2, CeO2 and MoO3; the phosphate is at least one selected from NbOPO4 and ZrOPO4; and the molecule sieve is at least one selected from Nb-SBA-15, Nafion, H-ZSM-5, H-Beta and H-Y.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: July 12, 2022
    Assignee: East China University of Science and Technology
    Inventors: Yanqin Wang, Yaxuan Jing, Yong Guo, Xiaohui Liu, Ning Yan
  • Patent number: 11345900
    Abstract: A monooxygenase having an amino acid sequence obtained by mutation of the amino acid sequence shown in SEQ ID NO:2 is disclosed. The use of the monooxygenase of the present invention in production of chiral sulfoxide-based drugs has advantages including mild reaction conditions, environmental friendliness, high yield, high optical purity of products, less peroxide products, and the like, and therefore the monooxygenase in the present invention has a good industrial application prospect in the production of proton pump inhibitors for the treatment of gastric ulcers.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: May 31, 2022
    Assignees: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD., EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Yan Zhang, Huilei Yu, Shimiao Ren, Peng Zhao, Jianhe Xu, Yinqi Wu, Qian Zhao
  • Publication number: 20220145023
    Abstract: The disclosure relates to the field of electronic materials, and in particular to a composite film of fluorinated polybenzoxazole (6FPBO) and triple-shelled mesoporous silica hollow spheres, and to its preparation and use. The composite film comprises fluorinated polybenzoxazole as a matrix and amino-functionalized triple-shelled mesoporous silica hollow spheres which are dispersed in the fluorinated polybenzoxazole matrix. A mass ratio of (amino-functionalized triple-shelled mesoporous silica hollow spheres)/(fluorinated polybenzoxazole) is 1/100 to 5/100. The composite film has excellent thermal stability and a lower dielectric constant.
    Type: Application
    Filed: November 1, 2021
    Publication date: May 12, 2022
    Applicant: East China University of Science and Technology
    Inventors: Qixin ZHUANG, Zhe ZHANG, Xiaoyun LIU, Jian XU, Wentao WANG, Zeyang WU, Xiaohan WU, Lihui LI
  • Patent number: 11320353
    Abstract: A creep strength analysis and assessment method includes comparing whether a maximum value of a local strain and a membrane strain are less than a corresponding allowable strain, and if less, determining that a component is safe; otherwise, performing the following steps: performing stress linearization on a path to obtain a local primary membrane stress PL and a local primary bending stress Pb; averaging shear stress components on the path to obtain an average shear stress ?m; obtaining a strength limit Smt, a time-independent minimum stress strength value Sm and a temperature- and time-dependent stress strength limit St for a given material, a design lifetime and a design temperature; comparing whether PL, PL+Pb and PL+Pb/Kt are less than Smt, KSm and St; and comparing whether ?m is less than 0.6Sm and 0.6St, and if less, the component is safe, otherwise, the component is unsafe.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: May 3, 2022
    Assignee: East China University of Science and Technology
    Inventors: Fuzhen Xuan, Tianye Niu, Jianguo Gong
  • Patent number: 11306259
    Abstract: The present disclosure relates to a method and an apparatus for self-heat-extracting flash evaporation of a sulfuric acid alkylation reaction product. There is provided a method for self-heat-extracting flash evaporation of a sulfuric acid alkylation reaction product. One step is to coalesce and vaporize a preliminarily distributed sulfuric acid alkylation reaction product to cause preliminary vaporization of a hydrocarbon therein, thereby taking heat away and preliminarily separating the hydrocarbon from sulfuric acid. Another step is to subject the preliminarily separated alkylation reaction to reinforced separation, where the hydrocarbon is further vaporized to take heat away and further separate the hydrocarbon from the sulfuric acid. There is also provided an apparatus for self-heat-extracting flash evaporation of a sulfuric acid alkylation reaction product.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: April 19, 2022
    Assignee: East China University of Science and Technology
    Inventors: Zhishan Bai, Yan Zhang, Xiaoyong Yang, Huiqing Luo
  • Patent number: 11306095
    Abstract: The present invention relates to a pteridinone derivative serving as an EGFR inhibitor and use thereof. Specifically, the present invention relates to a compound represented by the following formula I, pharmaceutical composition comprising the compound of the following formula I, and use of the compound in preparation of drugs for treating EGFR-mediated diseases or inhibiting EGFR.
    Type: Grant
    Filed: May 30, 2016
    Date of Patent: April 19, 2022
    Assignee: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Honglin Li, Yufang Xu, Zhenjiang Zhao, Wei Zhou, Yuqiong Xu, Deheng Sun, Xia Wang, Zhuo Chen
  • Patent number: 11291200
    Abstract: The present disclosure relates to the application of a viable cell monitor to the cryopreservation of plant cells. The viable cell monitor is, for the first time, used in a method for rapidly evaluating the effect of cell freezing-preservation. The effect of a cryoprotectant on cell preservation is evaluated through the change in the capacitance of viable cells before and after cell freezing and resuscitation. Viable cell electrodes can provide a quick and accurate characterization of viable cell concentrations. Combining the viable cell capacitance with the detection result of 2,3,4-triphenyl tetrazolium chloride (TTC), a rapid and quantitative evaluation of the effect of a freezing method on cell preservation can be achieved, thus overcoming the low effectiveness and non-quantification of previous cell preservation methods. Compared with traditional methods, the method of the present disclosure can improve the comprehensive score of cell cryopreservation by 5 times or more.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: April 5, 2022
    Assignee: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Meijin Guo, Jiarui Li, Zejian Wang, Yuxia Chen, Yingping Zhuang
  • Patent number: 11274988
    Abstract: The disclosure relates to a dual-criterion diagram for designing and assessing the life and strength of high-temperature rotating components and its establishment. In addition, the disclosure relates to a method for designing and assessing the life and strength of high-temperature rotating components based on the dual-criterion diagram for designing and assessing the life and strength of high-temperature rotating components. The advantages of the disclosure include a simple design and assessment process, high operability, and reliable assessment results. The invention is expected to be applied finally to assessment and evaluation of high-cycle fatigue life of rotating components at high temperatures.
    Type: Grant
    Filed: December 29, 2018
    Date of Patent: March 15, 2022
    Assignee: East China University of Science and Technology
    Inventor: Fuzhen Xuan
  • Publication number: 20220002216
    Abstract: Disclosed is a method for preparing aromatic hydrocarbons by hydrocracking a polymer containing aromatic rings, which includes reacting the polymer fragment with hydrogen under the action of a catalyst at a temperature of no more than 350° C.; separating a reaction product to obtain the aromatic hydrocarbons. The catalyst comprises a carrier and an active ingredient supported on the carrier, the active ingredient is at least one selected from Ru, Rh, Pt, Pd, Fe, Ni, Cu and Co, the carrier is at least one selected from metal oxide, phosphate, molecular sieve, SiO2 and sulfonated carbon, the metal oxide is at least one selected from Al2O3, Nb2O5, Nb2O5—Al2O3, Nb2O5—SiO2, TiO2, ZrO2, CeO2 and MoO3; the phosphate is at least one selected from NbOPO4 and ZrOPO4; and the molecule sieve is at least one selected from Nb-SBA-15, Nafion, H-ZSM-5, H-Beta and H-Y.
    Type: Application
    Filed: August 16, 2021
    Publication date: January 6, 2022
    Applicant: East China University of Science and Technology
    Inventors: Yanqin WANG, Yaxuan JING, Yong GUO, Xiaohui LIU, Ning YAN
  • Publication number: 20220002684
    Abstract: A monooxygenase having an amino acid sequence obtained by mutation of the amino acid sequence shown in SEQ ID NO:2 is disclosed. The use of the monooxygenase of the present invention in production of chiral sulfoxide-based drugs has advantages including mild reaction conditions, environmental friendliness, high yield, high optical purity of products, less peroxide products, and the like, and therefore the monooxygenase in the present invention has a good industrial application prospect in the production of proton pump inhibitors for the treatment of gastric ulcers.
    Type: Application
    Filed: November 26, 2019
    Publication date: January 6, 2022
    Applicants: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY, JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD.
    Inventors: Yan ZHANG, Huilei YU, Shimiao REN, Peng ZHAO, Jianhe XU, Yinqi WU, Qian ZHAO
  • Patent number: 11186552
    Abstract: A tebuconazole polymorph and a preparation method therefor are described. In particular, a polymorph of (RS)-1-(4-chloropheny)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl) pentan-3-ol, a preparation method therefor and use thereof are provided. The tebuconazole polymorph has a high purity and excellent crystallization properties, is stable under high humidity, high temperature and light conditions, has excellent solubility, and has high processing properties for formulations, high biological activities and good sterilization effects. The preparation method is simple, has stable processes, and can be implemented on a large scale. The polymorph can greatly improve the quality control and industrial application of tebuconazole-containing pesticides.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: November 30, 2021
    Assignee: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Zhong Li, Guobin Ren, Xiaoyong Xu, Minghui Qi, Jian Hu, Chengyu Gong
  • Publication number: 20210179598
    Abstract: Provided is a selective JAK2 inhibitor and application thereof. In particular, it relates to the compound of the following Formula (I), and the use of the compound in the treatment of JAK2-mediated related diseases and in the preparation of the medicament for treating JAK2-mediated related diseases.
    Type: Application
    Filed: April 12, 2019
    Publication date: June 17, 2021
    Applicant: East China University of Science and Technology
    Inventors: Honglin LI, Yufang XU, Zhenjiang ZHAO, Lili ZHU
  • Patent number: 11007456
    Abstract: The disclosure provides a short-process separation system for separating ionic liquid from alkylation reaction effluent, comprising an alkylation reactor, an ionic liquid storage tank, a primary coalescence separator, a secondary coalescence separator, a flash tank, a low-temperature fine coalescence separator and a fractionating tower that are linked in order. The inlet of the ionic liquid storage tank communicates with the bottom flow ports of the primary coalescence separator, the secondary coalescence separator and the low-temperature fine coalescence separator through delivery lines, and the outlet of the ionic liquid storage tank communicates with the return port of the alkylation reactor through a delivery pump. The alkylated oil collected from this system has a high degree of cleanliness, and can be used directly as a component for formulating clean gasoline. The ionic liquid catalyst collected therefrom may be directly returned to the alkylation reactor for cycle use.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: May 18, 2021
    Assignee: East China University of Science and Technology
    Inventors: Zhishan Bai, Zhaojin Lu