Abstract: A method of treating a subject suffering from an ischemic disease associated with Ca2+ overload is provided, the method including administering to the subject an effective amount of an inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. Also provided is a method of treating a subject suffering from acute ischemic stroke, the method including administering to the subject an effective amount of the ATR kinase inhibitor berzosertib.
Type:
Application
Filed:
September 22, 2023
Publication date:
January 11, 2024
Applicant:
East Tennessee State University Research Foundation
Abstract: A single-chain variable fragment (ScFv) derived from anti-c-Met monoclonal antibody MetMAb that specifically binds to c-Met receptor is provided. Also provided are chimeric antigen receptor (CAR) vectors including the ScFv, human T cells transduced with the disclosed CAR vectors, pharmaceutical compositions including the CAR T cells, ScFv fusion proteins, and methods of treating a c-Met-positive cancer or a cancer characterized by overexpression of c-Met in a subject in need thereof by administering an effective amount of the disclosed CAR T cells.
Type:
Grant
Filed:
November 2, 2020
Date of Patent:
January 9, 2024
Assignee:
EAST TENNESSEE STATE UNIVERSITY RESEARCH FOUNDATION
Abstract: Instructional dermatology surface models (IDSMs) useful as educational tools are provided herein, including a three-dimensional base rendered from at least one reference image of a skin lesion and a two-dimensional image layer rendered from the at least one reference image of the skin lesion disposed on a top surface of the three-dimensional base. Also provided are methods of manufacture, assembly, and use of the disclosed IDSMs, together with educational kits including a selection of IDSMs for simulating a variety of skin lesions.
Type:
Grant
Filed:
July 30, 2019
Date of Patent:
January 4, 2022
Assignee:
EAST TENNESSEE STATE UNIVERSITY RESEARCH FOUNDATION
Abstract: A single-chain variable fragment (ScFv) derived from anti-c-Met monoclonal antibody MetMAb that specifically binds to c-Met receptor is provided. Also provided are chimeric antigen receptor (CAR) vectors including the ScFv, human T cells transduced with the disclosed CAR vectors, pharmaceutical compositions including the CAR T cells, ScFv fusion proteins, and methods of treating a c-Met-positive cancer or a cancer characterized by overexpression of c-Met in a subject in need thereof by administering an effective amount of the disclosed CAR T cells.
Type:
Application
Filed:
November 2, 2020
Publication date:
May 6, 2021
Applicant:
East Tennessee State University Research Foundation
Abstract: Positive controls for experimentation related to membrane-bound glucose transporter proteins and methods for preparing such positive controls, such proteins including GLUT1, GLUT4, GLUT5, and GLUT12.
Type:
Grant
Filed:
December 11, 2009
Date of Patent:
July 24, 2012
Assignee:
East Tennessee State University Research Foundation
Abstract: Disclosed is a surgical simulator for teaching, practicing, and evaluating surgical techniques. Such a simulator may comprise a cassette of organs, blood vessels, and tissues that may be disposable. The simulator also comprises a hemodynamic simulator and a frame assembly, the frame assembly providing support for the cassette of organs as well as a fluid conduit through which simulated blood flow from the hemodynamic simulator may be connected to the blood vessels of the organs and related tissues. The hemodynamic simulator provides adjustable and variable pressures to the arteries and veins, as well as variable pulse rates, which can be programmed at settings chosen by an instructor or user.
Type:
Grant
Filed:
January 16, 2007
Date of Patent:
January 11, 2011
Assignee:
East Tennessee State University Research Foundation
Inventors:
William K. Hemphill, J. Paul Sims, Martin E. Olsen, Martin P. Eason, Sheldon R. Davis