Abstract: A novel method for synthesizing NCA compounds. Also, a new use of a peptide coupling agent. The method makes it possible to obtain NCA compounds from ?-amino-acids, under mild and non-racemic reaction conditions, and in the absence of constraining reagents of use, such as phosgene, which may lead to the formation of undesirable by-products.
Type:
Application
Filed:
December 21, 2021
Publication date:
April 4, 2024
Applicants:
ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER (ENSCM), UNIVERSITE DE MONTPELLIER (UM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Guillaume LACONDE, Jean MARTINEZ, Muriel AMBLARD-CAUSSIL
Abstract: Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (>600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.
Type:
Application
Filed:
March 26, 2013
Publication date:
March 26, 2015
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ECOLE NATIONAL SUPERIEURE DE CHIMIE DE MONTPELLIER
Inventors:
Frederique Cunin, Jean-Olivier Durand, Michael J. Sailor, Marcel Garcia, Emilie Secret, Magali Gary-Bobo, Marie Maynadier, Alain Morere
Abstract: The present invention relates to a method for preparing a silica grafted with an organosilicon compound, to a grafted silica obtained according to said method and to the use thereof in compositions of silicone crosslinkable into an elastomer.
Type:
Application
Filed:
August 16, 2012
Publication date:
October 9, 2014
Applicants:
BLUESTAR SILICONES FRANCE SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), ECOLE NATIONAL SUPÉRIEURE DE CHIMIE DE MONTPELLIER, UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUES