Abstract: The present invention concerns an organic cavity injection device including an injection cannula for injecting a photo-activatable substance inside an organic cavity; at least one element or a plurality of elements configured to control the removal of a resident substance from the organic cavity and simultaneously prevent removal of the non-activated photo-activatable substance from the organic cavity; and an optical waveguide for providing electromagnetic radiation inside the organic cavity to the photo-activatable substance to photoactive the photo-activatable substance inside the organic cavity.

Abstract: The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrial disease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including inhibiting the mitochondrial translation machinery function, as well as methods for screening agents that are able to increase lifespan, inhibit or delay aging, and/or prevent or treat an age-related disease or disorder, or a mitochondrial disease or disorder, in a subject.

Abstract: The aim of the invention is to propose the generation, verification and denial of an undeniable signature which has a size smaller than the currently available undeniable signatures, i.e. less than 80 bits. This aim is achieved by the method to generate an undeniable signature (y1, . . . , yt) on a set of data, this method comprising the following steps: (1) transforming the set of data (m) to a sequence of a predetermined number (t) of blocks (x1, . . . , xt), these blocks being members of an Abelian group, this transformation being a one way function, and (2) applying to each block (xi) a group homomorphism (f) to obtain a resulting value(yi), in which the number of elements of the initial group (G) is larger than the number of elements (d) of the destination group (H).