Abstract: The degree of phosphorylation of serine and threonine residues of p100/p120 can affect the permeability of physiological barriers and also cell-cell adhesion properties. By changing physiological levels, various disorders can be treated, including multiple sclerosis, cancer, head injuries, oedema, stroke, inflammation and gastric ulcers. Furthermore, drugs can be allowed to pass across physiological barriers and the barriers can then be closed.
Type:
Application
Filed:
May 24, 2002
Publication date:
October 3, 2002
Applicant:
Eisai Co., Limited
Inventors:
James Martin Staddon, Mary Louise Morgan, Marianne Jennifer Ratcliffe
Abstract: The degree of phosphorylation of serine and threonine residues of p100/p120 can affect the permeability of physiological barriers and also cell—cell adhesion properties. By changing physiological levels, various disorders can be treated, including multiple sclerosis, cancer, head injuries, oedema, stroke, inflammation and gastric ulcers. Furthermore, drugs can be allowed to pass across physiological barriers and the barriers can then be closed.
Type:
Grant
Filed:
March 29, 1999
Date of Patent:
June 18, 2002
Assignee:
Eisai Co., Limited
Inventors:
James Martin Staddon, Mary Louise Morgan, Marianne Jennifer Ratcliffe