Patents Assigned to Elobix AB
  • Solid formulation and method for preventing or reducing coloration thereof
    Patent number: 11844822
    Abstract: The present invention relates to stabilization of a certain benzothia(dia)zepine derivative in a solid formulation containing the same. In the present invention, in a solid formulation containing the benzothia(dia)zepine derivative mentioned above, a combination of polyethylene glycol and polyvinyl alcohol is not blended, or alternatively, in the case of blending polyethylene glycol and polyvinyl alcohol in the solid formulation, the aforementioned derivative is isolated from the combination of polyethylene glycol and polyvinyl alcohol.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: December 19, 2023
    Assignee: Elobix AB
    Inventors: Takahiko Ando, Hirokazu Hagio, Takashi Matsushita, Yusuke Ito
  • Process for the preparation of 1,5-benzothiazepine compounds
    Patent number: 10995115
    Abstract: The present invention relates to a process for the preparation of certain 1,5-benzothiazepine compounds, and in particular to a process for the preparation of elobixibat. The process can be carried out under mild and safe conditions and may be used to prepare elobixibat on an industrial scale. The invention also relates to a process for the preparation of a crystalline monohydrate of elobixibat.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: May 4, 2021
    Assignee: Elobix AB
    Inventors: Ganapati G. Bhat, Johnson M. Coutinho, Mikael Dahlström, Michael Lofthagen, Akinori Tatara
  • Solid formulation and method for preventing or reducing coloration thereof
    Patent number: 10709755
    Abstract: The present invention relates to stabilization of a certain benzothia(dia)zepine derivative in a solid formulation containing the same. In the present invention, in a solid formulation containing the benzothia(dia)zepine derivative mentioned above, a combination of polyethylene glycol and polyvinyl alcohol is not blended, or alternatively, in the case of blending polyethylene glycol and polyvinyl alcohol in the solid formulation, the aforementioned derivative is isolated from the combination of polyethylene glycol and polyvinyl alcohol.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: July 14, 2020
    Assignee: Elobix AB
    Inventors: Takahiko Ando, Hirokazu Hagio, Takashi Matsushita, Yusuke Ito
  • Crystal modifications of elobixibat
    Patent number: 10519120
    Abstract: The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methylthio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl]oxy}acetyl)amino]-2-phenylethanolyl}glycine (elobixibat).
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: December 31, 2019
    Assignee: Elobix AB
    Inventors: Ingvar Ymén, Martin Bohlin, Thomas Larsson, Helena Nicklasson
  • Process for the preparation of 1,5-benzothiazepine compounds
    Patent number: 10428109
    Abstract: The present invention relates to a process for the preparation of certain 1,5-benzothiazepine compounds, and in particular to a process for the preparation of elobixibat. The process can be carried out under mild and safe conditions and may be used to prepare elobixibat on an industrial scale. The invention also relates to a process for the preparation of a crystalline monohydrate of elobixibat.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: October 1, 2019
    Assignee: Elobix AB
    Inventors: Ganapati G. Bhat, Johnson M. Coutinho, Mikael Dahlström, Michael Lofthagen, Akinori Tatara
  • Crystal modifications of elobixibat
    Patent number: 10183920
    Abstract: The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methylthio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl]oxy}acetyl)amino]-2-phenylethanolyl}glycine (elobixibat).
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: January 22, 2019
    Assignee: Elobix AB
    Inventors: Ingvar Ymén, Martin Bohlin, Thomas Larsson, Helena Nicklasson
  • Crystal modifications of elobixibat
    Patent number: 9745276
    Abstract: The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methyl-thio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl]oxy}acetyl)amino]-2-phenylethanolyl}glycine (elobixibat), more specifically crystal modifications I, IV, MeOH-1, EtOH-1, 1-PrOH-1 and 2-PrOH-1. The invention also relates to a process for the preparation of these crystal modifications and to a pharmaceutical composition comprising crystal modification IV.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: August 29, 2017
    Assignee: Elobix AB
    Inventors: Martin Bohlin, Erica Tjerneld, Andreas Vestermark, Ingvar Ymen
  • Crystal modifications of elobixibat
    Patent number: 9701649
    Abstract: The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methyl-thio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl]oxy}acetyl)amino]-2-phenylethanolyl}glycine (elobixibat), more specifically crystal modifications I, IV, MeOH-1, EtOH-1, 1-PrOH-1 and 2-PrOH-1. The invention also relates to a process for the preparation of these crystal modifications and to a pharmaceutical composition comprising crystal modification IV.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: July 11, 2017
    Assignee: Elobix AB
    Inventors: Martin Bohlin, Erica Tjerneld, Andreas Vestermark, Ingvar Ymen
  • Crystal modifications of elobixibat
    Patent number: 9409875
    Abstract: The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methyl-thio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl]oxy}acetyl)amino]-2-phenylethanolyl}glycine (elobixibat), more specifically crystal modifications I, IV, MeOH-1, EtOH-1, 1-PrOH-1 and 2-PrOH-1. The invention also relates to a process for the preparation of these crystal modifications and to a pharmaceutical composition comprising crystal modification IV.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: August 9, 2016
    Assignee: Elobix AB
    Inventors: Martin Bohlin, Erica Tjerneld, Andreas Vestermark, Ingvar Ymen