Abstract: The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.
Type:
Application
Filed:
April 5, 2013
Publication date:
November 14, 2013
Applicant:
Emisphere Technologies, Inc.
Inventors:
Nikhil DHOOT, Steven DINH, Shingai MAJURU, William Elliott BAY, JoAnne P. CORVINO, Doris C. O'TOOLE
Abstract: The present invention relates to novel compounds, methods, and formulations useful for the oral delivery of a GLP-1 compound or an MC4 agonist peptide.
Type:
Grant
Filed:
December 11, 2009
Date of Patent:
October 8, 2013
Assignee:
Emisphere Technologies, Inc.
Inventors:
Robert Jason Herr, Louis Nickolaus Jungheim, John McNeil McGill, Kenneth Jeff Thrasher, Muralikrishna Valluri
Abstract: The present application relates to novel compounds, methods and formulations useful for the oral delivery of a glucagon like peptide-1 compound or a melanocortin 4 receptor agonist peptide.
Type:
Grant
Filed:
April 14, 2011
Date of Patent:
October 1, 2013
Assignee:
Emisphere Technologies, Inc.
Inventors:
Louis Nickolaus Jungheim, John Mcneill McGill, III, Kenneth Jeff Thrasher, Robert Jason Herr, Muralikrishna Valluri
Abstract: The invention relates to formulations that demonstrate the feasibility of oral absorption comprising glucose-like peptide-1 compounds and specified delivery agents, and to methods of stimulating GLP-1 receptor in a subject in need of such stimulation, by administration of the formulation of the present invention.
Type:
Grant
Filed:
January 12, 2011
Date of Patent:
July 23, 2013
Assignee:
Emisphere Technologies, Inc.
Inventors:
Mohammed Amin Khan, Bryan Edward Jones, John McNeill McGill
Abstract: The present invention relates to pharmaceutical compounds for delivering active agents, such as biologically or chemically active agents, to a target. The invention also relates to pharmaceutical compositions comprising at least one delivery agent compound of the present invention and at least one active agent, and unit dosage forms comprising such compositions. Methods for the preparation and administration of the pharmaceutical compositions are also disclosed.
Abstract: Solid pharmaceutical compositions and methods of their use suitable for the oral delivery of pharmacologically active agents, e.g. peptides, comprising a therapeutically-effective amount of a pharmacologically active agent; a crospovidone or povidone; and a delivery agent for said pharmacologically active agent are disclosed. The compositions utilize micronized forms of the delivery agent which provides enhanced bioavailability of pharmacologically active agents, particularly calcitonin.
Type:
Grant
Filed:
June 4, 2008
Date of Patent:
May 7, 2013
Assignees:
Novartis AG, Emisphere Technologies, Inc.
Inventors:
Shoufeng Li, Anasuya A Ghosh, Simon D Bateman, Moise Azria, Alan E Royce
Abstract: The present invention relates to crystalline polymorphic forms of the di-sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.
Type:
Grant
Filed:
August 11, 2011
Date of Patent:
April 30, 2013
Assignee:
Emisphere Technologies, Inc.
Inventors:
Nikhil Dhoot, Steven Dinh, Shingai Majuru, William Elliott Bay, JoAnne P. Corvino, Doris C. O'Toole
Abstract: Phenoxy carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
Type:
Grant
Filed:
July 18, 2006
Date of Patent:
April 2, 2013
Assignee:
Emisphere Technologies, Inc.
Inventors:
Andrea Leone-Bay, Kelly Kraft, Destardi Moye-Sherman, David Gschneidner, Maria Aurora P. Boyd, Puchun Liu, Pingwah Tang, Jun Liao, John Smart, John J. Freeman, Jr.
Abstract: Compounds comprising cyclic moiety and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
Abstract: Methods for treating impaired glucose tolerance and early and late stage diabetes in mammals, for prophylactically sparing ?-cell function, aiding in preventing ?-cell death, preventing the onset of overt diabetes in a mammal with type 2 diabetes, treating the current level of glycemic control dysfunction of a mammal with impaired glucose tolerance or diabetes, comprising orally administering insulin and a delivery agent that facilitates insulin absorption from the gastrointestinal tract at the time of or shortly before mealtime, e.g., within about 10 minutes prior to ingestion of a meal, on a chronic basis. The methods also comprise, in addition to administering a rapid-acting insulin to provide a first insulin peak, administering a slow acting insulin to provide a second insulin peak occurring at a later time but of a longer duration.
Type:
Grant
Filed:
August 24, 2009
Date of Patent:
December 4, 2012
Assignee:
Emisphere Technologies, Inc.
Inventors:
Ehud Arbit, Michael Goldberg, Shingal Majuru
Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.
Type:
Application
Filed:
May 25, 2012
Publication date:
October 18, 2012
Applicants:
NOVARTIS AG, Emisphere Technologies, Inc.
Inventors:
William E. BAY, Rajesh K. AGARWAL, Kiran CHAUDHARY, Shingai MAJURU, Michael M. GOLDBERG, JoAnne P. CORVINO, Moise AZRIA, Joseph M. AULT, Simon D. BATEMAN, Subash PATEL, Joseph SIKORA, Rebecca F. YANG, Joseph L. ZIELINSKI
Abstract: The present invention provides phenylalkylcarboxylic acid compounds and compositions containing such compounds which facilitate the delivery of biologically active agents.
Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
Type:
Grant
Filed:
May 16, 2005
Date of Patent:
September 25, 2012
Assignee:
Emisphere Technologies, Inc.
Inventors:
Maria Isabel Gomez-Orellana, David Gschneidner, Andrea Leone-Bay, Destardi Moye-Sherman, Stephen V. Pusztay, Parshuram Rath, Pingwah Tang, John J. Weidner, Jianfeng Song
Abstract: The present invention relates to acyclovir formulations having improved bioavailability resulting in better efficacy and/or requiring less frequent administration.
Abstract: This invention relates to microparticles and/or nanoparticles containing a delivery agent and/or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent.
Type:
Application
Filed:
November 23, 2011
Publication date:
July 26, 2012
Applicant:
Emisphere Technologies, Inc.
Inventors:
Nikhil Dhoot, Halina Levchik, Shingai Majuru, George Klein, Jamila Harris, Puchun Liu, Steven Dinh, Jun Liao, Jongbin Lee, Ehud Arbit, Nai Fang Wang