Abstract: Microfluidic “organ-on-a-chip” devices have been developed with the aim to replicate human tissues in vitro. However, there is no option to quantitatively monitor biological processes that take place within the chip, over time. Destructive methods in order to analyze, tissue formation, gene expression, protein secretion etc. require the harvest of the “tissue” at a certain time point. Described herein are methods and compositions for non-destructive molecular imaging methods and systems in order to quantitatively monitor specific biological processes, over time, within the chip, without the need to harvest.
Type:
Application
Filed:
September 13, 2018
Publication date:
January 10, 2019
Applicants:
Cedars-Sinai Medical Center, Emulate, Inc.
Inventors:
Dan GAZIT, Gadi PELLED, Zulma GAZIT, Dmitriy SHEYN, Christopher David Hinojosa, Norman Wen, Geraldine Hamilton
Abstract: Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
Type:
Grant
Filed:
August 26, 2016
Date of Patent:
November 13, 2018
Assignee:
EMULATE, Inc.
Inventors:
Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Guy Robert Thompson, II, Petrus Wilhelmus Martinus van Ruijven, Matthew Daniel Solomon, Christian Alexander Potzner, Patrick Sean Tuohy