Abstract: Apparatus (4020) comprising a pancreaticobiliary secretion-diversion guide (4030) for use with secretions that enter a gastrointestinal tract at an anatomical entry location. Guide (4030) comprises first and second anchors (4252/4054) which apply pressure to the wall of the tract. A resilient connecting element (2037) is coupled to the anchors. A collection-facilitation tube (2080) is between the anchors and in contact with and around element (2037). Tube (2080) has an inner surface (2045) and an outer surface (2046), the inner surface defining a lumen for passage of food. The outer surface inhibits contact of the secretions with food and defines a space (7) between the outer surface and the tract. A diversion tube (2090) is in fluid communication with the space and passes secretions from the space distally. An intragastric anchor (4152) coupled to the guide maintains the guide in place. Other applications are also described.

Abstract: Apparatus (20) for use with pancreaticobiliary secretions that enter a gastrointestinal tract of a subject at an anatomical entry location, the apparatus (20) comprising: a pancreaticobiliary secretion-diversion guide (30) configured to collect the pancreaticobiliary secretions from the anatomical entry location and deliver the pancreaticobiliary secretions to a location in the gastrointestinal tract that is distal to the anatomical entry location; and an anchoring system (40) comprising one or more helical anchors (80) located within the gastrointestinal tract and configured to apply pressure to a wall of the gastrointestinal tract in order to maintain the pancreaticobiliary secretion-diversion guide in place.

Abstract: Apparatus (200) for use with pancreaticobiliary secretions that enter a gastrointestinal tract at an anatomical location. A secretion-diversion guide (370) comprises: a proximal portion (124); a distal portion (126); first and second anchors (36/38) coupled to the proximal and distal portions which apply pressure to the tract to maintain guide (370) in place; a collection-facilitation tube (280), between the anchors, having an inner surface (245) and an outer surface (246), the inner surface defining a lumen for passage of food. The outer surface inhibits contact of the secretions with food and defines a space (7) between the outer surface and the tract. A diversion tube (290) is in communication with the space and passes secretions from the space distally, and inhibits food-secretion contact. An intragastric anchor (170/171/172) coupled to guide (370), located in the stomach, maintains the guide in place. Other applications are also described.

Abstract: Apparatus (20) for use with pancreaticobiliary secretions that enter a gastrointestinal tract of a subject at an anatomical entry location, the apparatus (20) comprising: a pancreaticobiliary secretion-diversion guide (30) configured to collect the pancreaticobiliary secretions from the anatomical entry location and deliver the pancreaticobiliary secretions to a location in the gastrointestinal tract that is distal to the anatomical entry location; and an anchoring system (40) comprising one or more helical anchors (80) located within the gastrointestinal tract and configured to apply pressure to a wall of the gastrointestinal tract in order to maintain the pancreaticobiliary secretion-diversion guide in place.