Abstract: Disclosed is an intraluminal gastrointestinal (GI) device that is placed at the time of surgery to protect a freshly constructed GI anastomosis, GI staple-line, or the like. For the esophagus and stomach, the device covers the esophagus, stomach, and anastomosis/staple-line. For the pancreas or biliary duct, the device covers the biliary duct, pancreatic duct, and small bowel. For the colon and rectum, the device is a self expanding protective barrier that covers the anal canal, the anus, and the colon or rectum, approximately 18 cm proximal to the anus. These devices provide a waterproof barrier between the gastrointestinal content and the mucosa of the GI tract and the newly constructed anastomosis. Additionally, the design of the device is made to prevent migration within the gastrointestinal tract and facilitate removal of the device.