Patents Assigned to EnLiSense, LLC
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Publication number: 20230408499Abstract: Disclosed herein are devices, apparatus, systems, methods and kits for performing immunoassay tests on a sample. The A sensing apparatus is provided for detecting a plurality of different target analytes in a sample. The apparatus may comprise an array of sensing devices provided on a substrate, each sensing device in the array comprising a working electrode having (1) semiconducting nanostructures disposed thereon and (2) a capture reagent coupled to the semiconducting nanostructures that selectively binds to a different target analyte in the sample. The apparatus may also comprise sensing circuitry that (1) simultaneously detects changes to electron and ion mobility and charge accumulation in the array of sensing devices when the capture reagents in the array of sensing devices selectively bind to the plurality of different target analytes, and (2) determines the presence and concentrations of the plurality of different target analytes in the sample based on the detected changes.Type: ApplicationFiled: August 2, 2023Publication date: December 21, 2023Applicants: EnLiSense LLC, Board of Regents, The University of Texas SystemInventors: Sriram Muthukumar, Shalini Prasad
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Patent number: 11782055Abstract: Disclosed herein are devices, apparatus, systems, methods and kits for performing immunoassay tests on a sample. The A sensing apparatus is provided for detecting a plurality of different target analytes in a sample. The apparatus may comprise an array of sensing devices provided on a substrate, each sensing device in the array comprising a working electrode having (1) semiconducting nanostructures disposed thereon and (2) a capture reagent coupled to the semiconducting nanostructures that selectively binds to a different target analyte in the sample. The apparatus may also comprise sensing circuitry that (1) simultaneously detects changes to electron and ion mobility and charge accumulation in the array of sensing devices when the capture reagents in the array of sensing devices selectively bind to the plurality of different target analytes, and (2) determines the presence and concentrations of the plurality of different target analytes in the sample based on the detected changes.Type: GrantFiled: October 19, 2017Date of Patent: October 10, 2023Assignees: EnLiSense, LLC, Board of Regents, The University of Texas SystemInventors: Sriram Muthukumar, Shalini Prasad
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Publication number: 20210325380Abstract: A sensor device includes a porous substrate layer and an array of sensors to accept a sample. The array of sensors includes a plurality of sensors, each of the plurality of sensors includes respective semiconducting nanostructures with a respective capture reagent coupled to the semiconducting nanostructures that selectively binds to a respective target analyte in the sample. The array of sensors includes a first subset of sensors with first capture reagents to bind to biomarkers characteristic of a particular disease and a second subset of sensors with second capture reagents to bind to one of cytokines, chemokines, enzymes, metabolites, or antibodies present in the sample.Type: ApplicationFiled: April 20, 2021Publication date: October 21, 2021Applicant: EnLiSense, LLCInventor: Sriram Muthukumar
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Publication number: 20200054259Abstract: Systems, methods, and devices include a high-density analog multiplexer topology. Such topologies can be used, for example, in sensor device applications. An analog multiplexer circuit can include circuitry to receive N input signals; and circuitry to generate N selection signals for selecting one of said N data signals to be output from said analog multiplexer circuit. The analog multiplexer comprises one or more analog impedances.Type: ApplicationFiled: August 16, 2019Publication date: February 20, 2020Applicant: EnLiSense, LLCInventors: Devangsingh Gajendarsingh Sankhala, Sriram Muthukumar
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Publication number: 20190250153Abstract: Disclosed herein are devices, apparatus, systems, methods and kits for performing immunoassay tests on a sample. The A sensing apparatus is provided for detecting a plurality of different target analytes in a sample. The apparatus may comprise an array of sensing devices provided on a substrate, each sensing device in the array comprising a working electrode having (1) semiconducting nanostructures disposed thereon and (2) a capture reagent coupled to the semiconducting nanostructures that selectively binds to a different target analyte in the sample. The apparatus may also comprise sensing circuitry that (1) simultaneously detects changes to electron and ion mobility and charge accumulation in the array of sensing devices when the capture reagents in the array of sensing devices selectively bind to the plurality of different target analytes, and (2) determines the presence and concentrations of the plurality of different target analytes in the sample based on the detected changes.Type: ApplicationFiled: October 19, 2017Publication date: August 15, 2019Applicants: EnLiSense, LLC, Board of Regents, The University of Texas SystemInventors: Sriram Muthukumar, Shalini Prasad
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Patent number: 10006882Abstract: An example biosensor is provided and includes a semiconductor sensing element, a first electrode and a second electrode located on a first plane of the sensing element with a first electric field being applied thereacross, a third electrode located on a second plane of the sensing element parallel to and removed from the first plane with a second electric field being applied across the first electrode and the third electrode perpendicular to the first electric field, and a dielectric substrate having a first portion that constrains a fluid including an analyte on a surface of the sensing element, and a second portion that facilitates dielectric separation of the fluid from the electrodes. The mutually perpendicular electric fields facilitate adjusting a height of a fluid-sensor interface comprising an electrical double layer in the fluid enabling detection and characterization of the analyte.Type: GrantFiled: November 20, 2015Date of Patent: June 26, 2018Assignee: EnLiSense, LLCInventors: Shalini Prasad, Sriram Muthukumar, Anjan Panneer Selvam