Abstract: A compact, autoclavable needle safety device includes an adjustable cavity having an open position sized to receive a needle protective cap and a closed position to grip the cap within the cavity. The cavity is biased toward one of the positions and adjustable to the other position by single-handed actuation of a handle. In the closed position, the cap is gripped in place while allowing withdrawal of a syringe including a needle for use. The device maintains the cap open-end-up on an underlying surface for reinserting the needle to avoid exposing the user's hand to needle stick injury.