Abstract: Systems and methods are described herein to implement transverse momentum injection at low frequencies to directly modify large-scale eddies in a turbulent boundary layer on a surface of an object. A set of transverse momentum injection actuators may be positioned on the surface of the object to affect large-scale eddies in the turbulent boundary layer. The system may include a controller to selectively actuate the transverse momentum injection actuators with an actuation pattern to affect the large-scale eddies to modify the drag, fluid mixing, heat transfer, and/or other interactions of the fluid flow with the surface. In various embodiments, the transverse momentum injection actuators may be operated at frequencies less than 10,000 Hertz.