Abstract: A device insertable in the ear canal for substance delivery to and/or extraction from the tympanic cavity is described that includes a stationary body having a distal surface, a proximal surface; a movable body having a distal surface and a proximal surface, disposed within the stationary body and free to move relative to the stationary body in response to a pressure difference created in the ear canal; and at least one piercing element having a distal end and a proximal end, disposed in the movable body.

Abstract: A device for substance delivery to and/or extraction from the tympanic cavity, comprising: a stationary body having a distal surface, a proximal surface; a movable body having a distal surface and a proximal surface, disposed within the stationary body and free to move relative to the stationary body; at least one piercing element having a distal end and a proximal end, disposed in the movable body; and a means for moving the movable body relative to the stationary body.

Abstract: A device for substance delivery to and/or extraction from the tympanic cavity, comprising: a stationary body having a distal surface, a proximal surface; a movable body having a distal surface and a proximal surface, disposed within the stationary body and free to move relative to the stationary body; at least one piercing element having a distal end and a proximal end, disposed in the movable body; and a means for moving the movable body relative to the stationary body.

Abstract: A device for substance delivery to and/or extraction from the tympanic cavity, comprising: a housing, having a distal surface, a proximal surface that is opposite to the distal surface, and a circumscribed surface that connects the distal surface and the proximal surface; at least one piercing element having at least one proximal piercing end and at least one distal piercing end, disposed within the housing in such manner that the at least one distal piercing end is/are generally facing the distal surface of the housing; and a means for flexing the tympanic membrane toward the distal end of the at least one piercing element.