Abstract: A hyperbaric oxygen chamber for treatment of large animals such as horses is disclosed. The chamber is large enough for a horse to fit inside and comfortably move around. A specially designed davit door, though quite heavy, is easily manipulated and may be used to corral the horse during ingress or egress, and is serviceable using fluorocarbon lubricants. The door, sidewalls, and floor of the hyperbaric chamber are coated with a static dissipative polyurethane material suitable for oxygen environments and may protect the horse from injury and prevent sparks. The flooring is specially designed to allow the horse to eliminate during treatment, and may be cleaned easily and thoroughly without disassembly. The control mechanisms of the hyperbaric chamber include electro-pneumatic controls, for avoiding a fire hazard.