Patents Assigned to Eramus Universiteit
  • Lysosomal proteins produced in the milk of transgenic animals
    Patent number: 6118045
    Abstract: The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6' position of a mannose side chain residue. Also provided are methods of purifying lysosomal proteins from milk, and incorporating the proteins into pharmaceutical compositions for use in enzyme replacement therapy.
    Type: Grant
    Filed: July 29, 1996
    Date of Patent: September 12, 2000
    Assignees: Pharming B.V., The Universiteit Leiden, Academic Hospital, Eramus Universiteit
    Inventors: Arnold J. J. Reuser, Ans T. Van der Ploeg, Frank R. Pieper, Martin Ph. Verbeet