Abstract: A pharmaceutical MR (modified release) multiparticulate dosage form such as a capsule (once-a-day MR Capsule) of Methylphenidate indicated for the treatment of children with attention deficit hyperactivity disorder (ADHD), capable of delivering a portion of the dose for rapid onset of action and the remainder of the dose in a controlled manner for about 12 hours, is composed of a multitude of multicoated particles made of two populations of drug layered beads, IR (immediate release) and ER (extended release) Beads. The IR beads preferably are made by layering an aqueous solution comprising a drug and a binder on to non-pareil sugar spheres and then applying a seal coat to the drug coated cores. The ER Beads are made by applying an extended release coating of a water insoluble dissolution rate controlling polymer such as ethylcellulose to IR Beads.

Abstract: A taste-masked microcapsule composition for administration of a drug is provided. The composition comprises microcapsules of drug and a substantially water-insoluble polymeric material, typically a cellulosic polymer. The microcapsule composition may be incorporated into any number of pharmaceutical formulations, including chewable tablets, effervescent tablets, powders, liquid dispersions, and the like. A method for masking the taste of drugs is also provided, involving a phase separation coacervation technique in which drug is coated with relatively high levels of a polymeric material. These high coating levels give rise to effective taste masking, while nevertheless allowing targeted release of drug, so that the drug is released shortly after passage through the mouth.

Abstract: This disclosure is directed to preparation of individual taste-masked, high bioavailability, high payload, microcapsules by microencapsulation of water-insoluble NSAID drug materials in the substantial absence of microcapsule agglomerates. These taste-masked microcapsules contain a high payload, e.g., about 83+ wt. % of said NSAID drug material having high bioavailability and can then be formulated into chewable tablets and liquid aqueous suspensions for medicinal use. Both cellulose acetate phthalate and gelatin are the microencapsulating polymer wall material.

Abstract: This disclosure is directed to preparation of individual taste-masked, high bioavailability, high payload, microcapsules by microencapsulation of water-insoluble NSAID drug materials in the substantial absence of microcapsule agglomerates. These taste-masked microcapsules contain a high payload, e.g., about 83+wt. % of said NSAID drug material having high bioavailability and can then be formulated into chewable tablets and liquid aqueous suspensions for medicinal use. Both cellulose acetate phthalate and gelatin are the microencapsulating polymer wall material.

Abstract: A controlled release formulation of a calcium channel blocker for oral administration contains non-pareil seeds loaded with a calcium channel blocker, particularly diltiazem, nifedipine, or verapamil, and then microencapsulated in ethylcellulose by phase separation techniques. The resultant microcapsules provide an approximately zero order release rate, preferably over 12 to 16 hours. These microcapsules may be filled into gelatin capsules.

Abstract: This disclosure is directed to a high solid, low viscosity carbonless paper gelatin base microcapsule system producing microcapsules having sizes characteristically from about 3 to about 10 microns (micrometers) and being characterized as single oil drop microcapsules. This system of microcapsules is further characterized by a high solids content, viz., from about 25 to about 50 weight percent solids, in combination with a low viscosity, viz., ranging from about 10 to about 60 centipoises and having a high microcapsule payload (core concentration by weight based on total capsule weight), e.g., of 80+wt. % and preferbly about 90 weight percent and higher, in aqueous suspensions. The combination of high solid content and high microcapsule payload, with low viscosity enables delivery of a high concentration of solid microcapsules at reasonably high coating speeds via comparatively inexpensive conventional pumping systems and paper coating systems.

Abstract: This disclosure is directed to a high solid, low viscosity carbonless paper gelatin base microcapsule system producing microcapsules having sizes characteristically from about 3 to about 10 microns (micrometers) and being characterized as single oil drop microcapsules. This system of microcapsules is further characterized by a high solids content, viz., from about 25 to about 50 weight percent solids, in combination with a low viscosity, viz., ranging from about 10 to about 60 centipoises and having a high microcapsule payload (core concentration by weight based on total capsule weight), e.g., of 80+ wt. % and preferably about 90 weight percent and higher, in aqueous suspensions. The combination of high solid content and high microcapsule payload, with low viscosity enables delivery of a high concentration of solid microcapsules at reasonably high coating speeds via comparatively inexpensive conventional pumping systems and paper coating systems.

Abstract: This disclosure is directed to the preparation of dry microencapsulated product, having an oily core material with microcapsule cell wall materials having a first cell wall of gelatin/polyvinyl methylether maleic anhydride copolymer (PVMMA)/carboxymethylcellulose (CMC) which is prehardened (cross-linked) with a material selected from the group consisting of formaldehyde, glyoxal and glutaraldehyde to which there is grafted formaldehyde and resorcinol which is then crosslinked with formaldehyde and urea, and aqueous formulations containing them. Approximately 97% of these microcapsules have a size less than 100 and more characteristically having a particle size peak distribution of 30 to 40 microns (microcapsular diameter). These microcapsules contain less than approximately 3 wt. % free oil and more characteristically less than about 1 wt.

Abstract: Microcapsules are prepared en masse which contain a substantially water-insoluble core and, incorporated at their surface under a thin film of hydrophilic polymeric colloid, a substantially water insoluble finely divided additive. In the preparation, a primary microcapsule is made in an aqueous vehicle to surround the water-insoluble core, the finely divided additive is then added under stirring to form a fine dispersion and cationic hydrophilic polymeric colloid solution is added to cause the colloid to envelop the additive and deposit it on the capsule wall under a thin film.