Abstract: A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of ethylcellulose is obtained by overcoating a substrate including a therapeutically active agent with an aqueous dispersion of ethylcellulose and then curing the coated substrate at a temperature and relative humidity elevated to a suitable level above ambient conditions until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and/or elevated relative humidity.
Type:
Grant
Filed:
December 24, 1991
Date of Patent:
December 28, 1993
Assignee:
Euroceltigue, S.A.
Inventors:
Benjamin Oshlack, Frank Pedi, Jr., Mark Chasin