Patents Assigned to Exact Sciences Corporation
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Patent number: 11674168Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.Type: GrantFiled: September 24, 2020Date of Patent: June 13, 2023Assignee: Exact Sciences CorporationInventors: Hatim Allawi, Graham P. Lidgard, Brian Aizenstein, Tamara J. Sander, Maria Giakoumopoulos, Michael W. Kaiser, Melissa M. Gray, Abram Michael Vaccaro
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Patent number: 11479823Abstract: Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.Type: GrantFiled: October 23, 2020Date of Patent: October 25, 2022Assignee: Exact Sciences CorporationInventors: Hatim Allawi, Graham P. Lidgard, Chateen Krueger, Michael W. Kaiser, Tamara J. Sander
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Patent number: 11385243Abstract: A stool resuspension solution comprising a hemoglobin stabilization reagent is provided. In some embodiments, the hemoglobin stabilization reagent may be an osmolyte, a polyvalent cation, a sugar or polysaccharide and, optionally, a polyvalent cation, a protoporphyrin, or an HRP stabilization component and, optionally, a polyvalent cation. A method of stabilizing hemoglobin in a stool sample in the solution is also provided, as well as a sample collection device containing the solution.Type: GrantFiled: March 15, 2019Date of Patent: July 12, 2022Assignee: EXACT SCIENCES CORPORATIONInventors: Keith D. Fourrier, Jacquelyn T. Hennek, Michael J. Domanico, William G. Weisburg, Graham P. Lidgard, Kathleen S. Harings, Daniel J. Simpson
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Patent number: 11365451Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.Type: GrantFiled: April 30, 2019Date of Patent: June 21, 2022Assignees: Mayo Foundation for Medical Education and Research, Exact Sciences CorporationInventors: David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi
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Patent number: 11345949Abstract: Provided herein is technology relating compositions and methods for analysis of methylated DNA from a subject. The technology also relates to use of endogenous methylated DNAs as internal controls for marker gene methylation assays.Type: GrantFiled: July 19, 2017Date of Patent: May 31, 2022Assignee: Exact Sciences CorporationInventors: Hatim T. Allawi, Graham P. Lidgard
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Patent number: 11299766Abstract: Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA. The technology further provides methods for isolating DNA from blood or blood product samples, e.g., plasma samples.Type: GrantFiled: May 29, 2020Date of Patent: April 12, 2022Assignee: Exact Sciences CorporationInventors: Graham P. Lidgard, Hatim Allawi
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Patent number: 11020096Abstract: Provided herein is technology relating to collecting and preparing samples. For example, the technology relates particularly, but not exclusively, to devices, systems, and kits that allow a subject to collect and prepare a sample for analysis.Type: GrantFiled: May 29, 2020Date of Patent: June 1, 2021Assignee: Exact Sciences CorporationInventors: Graham P. Lidgard, Michael J. Domanico, Keith Fourrier, James P. Light, II, Scott Castanon, Keith Kopitzke
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Patent number: 10894256Abstract: Provided herein is technology relating to collecting and containing samples and particularly, but not exclusively, to technology for collecting and containing a stool specimen. The technology provides a device for collecting and containing a stool specimen, the device comprising ergonomic features optimized for a geriatric user. The technology also provides an enclosing holder for securing the ergonomic stool specimen container in a leak-proof manner e.g., during mechanical shaking.Type: GrantFiled: February 14, 2019Date of Patent: January 19, 2021Assignee: EXACT SCIENCES CORPORATIONInventors: Joseph E. Schiestle, Krystal A. Burger, Timothy A. Parmer, Jad A. Lunde, Sam M. Jang, David A. Schuelke, David B. Wolgemuth, Jing Yang Lu
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Patent number: 10822639Abstract: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool.Type: GrantFiled: December 6, 2018Date of Patent: November 3, 2020Assignee: Exact Sciences CorporationInventors: Janelle J. Bruinsma, Michael J. Domanico, Graham P. Lidgard, Hongzhi Zou, William G. Weisburg, Hemanth D. Shenoi, James P. Light, II, Keith Kopitzke, John Zeis
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Patent number: 10702250Abstract: Provided herein is technology relating to collecting and preparing samples. For example, the technology relates particularly, but not exclusively, to devices, systems, and kits that allow a subject to collect and prepare a sample for analysis.Type: GrantFiled: August 8, 2017Date of Patent: July 7, 2020Assignee: EXACT SCIENCES CORPORATIONInventors: Graham P. Lidgard, Michael J. Domanico, Keith Fourrier, James P. Light, II, Scott Castanon, Keith Kopitzke
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Patent number: 10486158Abstract: Provided herein is technology relating to processing samples and particularly, but not exclusively, to technology for containing and processing a stool specimen. The technology provides an enclosing holder for securing a sample container in a leak-proof manner e.g., during mechanical shaking.Type: GrantFiled: February 22, 2016Date of Patent: November 26, 2019Assignee: EXACT SCIENCES CORPORATIONInventor: Timothy E. Higgins
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Patent number: 10265054Abstract: Provided herein is technology relating to collecting and containing samples and particularly, but not exclusively, to technology for collecting and containing a stool specimen. The technology provides a device for collecting and containing a stool specimen, the device comprising ergonomic features optimized for a geriatric user. The technology also provides an enclosing holder for securing the ergonomic stool specimen container in a leak-proof manner e.g., during mechanical shaking.Type: GrantFiled: August 29, 2014Date of Patent: April 23, 2019Assignee: Exact Sciences CorporationInventors: Joseph E. Schiestle, Krystal A. Burger, Timothy A. Parmer, Jad A. Lunde, Sam M. Jang, David A. Schuelke, David B. Wolgemuth, Jing Yang Lu
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Patent number: 10196676Abstract: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool.Type: GrantFiled: July 26, 2018Date of Patent: February 5, 2019Assignee: Exact Sciences CorporationInventors: Janelle J. Bruinsma, Michael J. Domanico, Graham P. Lidgard, Hongzhi Zou, William G. Weisburg, Hemanth D. Shenoi, James P. Light, II, Keith Kopitzke, John Zeis
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Patent number: 10047390Abstract: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool.Type: GrantFiled: November 9, 2017Date of Patent: August 14, 2018Assignee: Exact Sciences CorporationInventors: Janelle J. Bruinsma, Michael J. Domanico, Graham P. Lidgard, Hongzhi Zou, William G. Weisburg, Hemanth D. Shenoi, James P. Light, II, Keith Kopitzke, John Zeis
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Publication number: 20180037958Abstract: Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).Type: ApplicationFiled: March 23, 2016Publication date: February 8, 2018Applicants: Exact Sciences Corporation, Mayo Foundation for Medical Education and ResearchInventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Douglas W. Mahoney, Tracy C. Yab, Graham P. Lidgard, Hatim T. Allawi
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Patent number: 9856515Abstract: Provided herein is technology relating to processing and preparing samples and particularly, but not exclusively, to methods, systems, and kits for removing assay inhibitors, e.g., compounds that inhibit polymerase chain reaction, from samples comprising nucleic acids. In particular, the technology is directed toward treating crude sample preparations, such as supernatants from homogenized stool samples, with insoluble polyvinylpyrrolidone (PVP) to form PVP-assay inhibitor complexes, and filtration to separate the PVP-assay inhibitor complexes from the crude sample preparations to produce clarified samples that exhibit reduced assay inhibition.Type: GrantFiled: March 3, 2015Date of Patent: January 2, 2018Assignee: Exact Sciences CorporationInventors: Janelle J. Bruinsma, Hemanth D. Shenoi, Michael J. Domanico, James P. Light, II
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Patent number: 9845491Abstract: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool.Type: GrantFiled: November 12, 2015Date of Patent: December 19, 2017Assignee: Exact Sciences CorporationInventors: Janelle J. Bruinsma, Michael J. Domanico, Graham P. Lidgard, Hongzhi Zou, William G. Weisburg, Hemanth D. Shenoi, James P. Light, II, Keith Kopitzke, John Zeis
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Patent number: 9783856Abstract: Provided herein is reagent mixture comprising multiplexed amplification reagents and flap assay reagents for detecting, in a single reaction, mutant copies of the KRAS gene that contain any of the 34A, 34C, 34T, 35A, 35C, 35T or 38A point mutations. Methods that employ the reagent mix and kits for performing the same are also provided.Type: GrantFiled: July 28, 2015Date of Patent: October 10, 2017Assignee: EXACT SCIENCES CORPORATIONInventors: Rebecca Oldham-Haltom, Hatim Allawi, Hongzhi Zou, Michael J. Domanico, Graham P. Lidgard
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Patent number: 9750482Abstract: Provided herein is technology relating to collecting and preparing samples. For example, the technology relates particularly, but not exclusively, to devices, systems, and kits that allow a subject to collect and prepare a sample for analysis.Type: GrantFiled: November 12, 2015Date of Patent: September 5, 2017Assignee: EXACT SCIENCES CORPORATIONInventors: Graham P. Lidgard, Michael J. Domanico, Keith Fourrier, James P. Light, II, Scott Castanon, Keith Kopitzke
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Patent number: D849266Type: GrantFiled: February 22, 2016Date of Patent: May 21, 2019Assignee: Exact Sciences CorporationInventor: Timothy E. Higgins