Patents Assigned to Expression Therapeutics, LLC.
  • COMPOSITIONS AND METHODS FOR PROMOTING HEMATOPOIETIC CELL CYTOTOXICITY
    Publication number: 20220378827
    Abstract: Provided herein are compositions and methods for promoting hematopoietic cell cytotoxicity.
    Type: Application
    Filed: April 12, 2020
    Publication date: December 1, 2022
    Applicants: EMORY UNIVERSITY, CHILDREN'S HEALTHCARE OF ATLANTA, INC., EXPRESSION THERAPEUTICS LLC
    Inventors: Harold Trent Spencer, Christopher Doering, Shanmuganathan Chandrakasan, Lauren Fleischer, Jaquelyn Zoine, Gianna Branella, Harrison C. Brown
  • High yield suspension cell line, system and method for making same
    Patent number: 8986991
    Abstract: A system and method of adapting host cells to suspension cell culture and suspension cell lines ATCC PTA-12593 and ATCC PTA-12461 produced thereby are disclosed. The method includes the serial replating of substantially undiluted culture cells onto a surface area until cell clumps are visualized and then, upon cell clumping, moving the cells into a suspension culture system.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: March 24, 2015
    Assignee: Expression Therapeutics, LLC
    Inventors: Gabriela D. C. Denning, Richard E Gautney
  • Nucleic acid and amino acid sequences encoding high-level expressor factor VIII polypeptides and methods of use
    Patent number: 8519111
    Abstract: Methods and compositions are provided that allow for high-level expression of a factor VIII polypeptide. More specifically, methods and compositions are provided comprising nucleic acid and amino acid sequences comprising a modified factor VIII that result in high-level expression of the polypeptide. The methods and compositions of the invention find use in the treatment of factor VIII deficiency including, for example, hemophilia A.
    Type: Grant
    Filed: May 27, 2012
    Date of Patent: August 27, 2013
    Assignee: Expression Therapeutics LLC
    Inventor: John S Lollar
  • Nucleic acid and amino acid sequences encoding high-level expressor factor VIII polypeptides and methods of use
    Patent number: 8188246
    Abstract: Methods and compositions are provided that allow for high-level expression of a factor VIII polypeptide. More specifically, methods and compositions are provided comprising nucleic acid and amino acid sequences comprising a modified factor VIII that result in high-level expression of the polypeptide. The methods and compositions of the invention find use in the treatment of factor VIII deficiency including, for example, hemophilia A.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: May 29, 2012
    Assignee: Expression Therapeutics LLC
    Inventor: John S. Lollar
  • Nucleic acid and amino acid sequences encoding high-level expressor factor VIII polypeptides and methods of use
    Patent number: 7635763
    Abstract: Methods and compositions are provided that allow for high-level expression of a factor VIII polypeptide. More specifically, methods and compositions are provided comprising nucleic acid and amino acid sequences comprising a modified factor VIII that result in high-level expression of the polypeptide. The methods and compositions of the invention find use in the treatment of factor VIII deficiency including, for example, hemophilia A.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: December 22, 2009
    Assignee: Expression Therapeutics, LLC.
    Inventor: John S. Lollar