Abstract: A process of production of trazodone or trazodone hydrochloride that comprises: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heating at a temperature of at least 40° C. for at least 30 minutes; (e) recovering said trazodone; and, optionally, (f) treating said trazodone with hydrochloric acid to obtain trazodone hydrochloride. Trazodone or trazodone hydrochloride comprising less than 15 ppm of alkylating substances, and a pharmaceutical composition comprising said trazodone hydrochloride.

Abstract: Disclosed are a rolling bearing with fully-filled plastic oil and a manufacturing method therefor. A clearance between the existing cage and an outer ring raceway or outer ring flange or/and between the cage and an inner ring raceway or/and inner ring flange is so small that a plastic oil fluid cannot be filled into a free space inside the bearing fully, which not only limits the advantages of plastic oil-lubricated bearings, but also has other negative effects. In the invention, without affecting the performance of the bearing, unilateral radial clearances between the cage and an outer ring and between the cage and an inner ring are increased to over 0.

Abstract: A raw water isolator for watercraft for providing treated fluid to loop of air conditioning units, freezers, ice makers, gyro stabilizers and the like systems. The raw water isolator provides a closed loop of treated fluid to prevent such systems from exposure to raw water known to contain biological material capable of fouling the units, and associated corrosion when salt water is used for the cooling mechanism. The apparatus employs a storage and expansion tank for holding a volume of fluid that is circulated through the marine units. A heat exchanger selected for ease of cleaning provides heat transfer between the cooling fluid and raw water.

Abstract: A pump container includes: a container in which a liquid is contained; a shoulder member configured as a cylindrical member, the upper and lower portions of which are open, the shoulder member having a lower outer peripheral portion formed to have an inner diameter larger than that of an upper inner peripheral portion; a valve housing comprising a cylinder portion, a hose being inserted/connected into/to the lower portion of the cylinder portion, the upper portion of the cylinder portion being open, the valve housing comprising an outer-periphery cylinder portion configured on the outer peripheral edge of the cylinder portion in a flared shape, the upper portion of the outer-periphery cylinder portion being open, the valve housing comprising an upper-end insertion portion bent outwards, and the valve housing comprising a seating portion bent outwards from the upper end of the upper-end insertion portion and a discharge cap.

Abstract: Method for expanding stemness and differentiation potential of pluripotent cells. The invention is based on the finding that increasing micro RNA-203 levels in induced pluripotent stem (iPSCs) or embryonic stem (ESCs) cells improves the quality cell fate potential and ability of these cells to differentiate into multiple cell lineages and to reach further maturation properties without interfering with their self-renewal properties. This effect is mediated through the mi R-203-dependent control of de novo DNA methyltransferases Dnmt3a and Dnmt3b, which in turn regulate the methylation landscape of pluripotent cells. The effect can be achieved by overexpression of micro RNA-203 or by adding micro RNA-203 or analogues thereof to the cell culture medium and can be observed using a variety of cellular and in vivo models.

Abstract: I. an inorganic-organic hybrid material obtained from A1. one or more partially hydrolysed alkoxysilanes of the formula (Ia), (R1O)nSiR23-nR3 (Ia) A2. optionally one or more partially hydrolysed alkoxysilanes of the formula (Ib), (R4O)nSiR54-n (Ib) B1. one or more metal alkoxides of the formula (IIa), Ti(OR6)4 (IIa) B2. optionally one or more metal alkoxides of the formula (IIb), M+(4-m)(OR7)4-m (IIb) wherein the symbols and indices have the definitions specified in the description and wherein the molar ratio of Si in components A1 and A2 to Ti in component B1 is 1-20:1; C. one or more oligomeric or polymeric polyols; D. one or more blocked, optionally modified polyisocyanates; and E. optionally one or more monomers, oligomers and/or polymers which have one or more free epoxy groups; II. optionally one or more colorants and III. optionally one or more adjuvants, is suitable especially for the decorative and protective coating of metal, glass and plastics substrates.

Abstract: The present invention relates to a pharmaceutical composition comprising a combination of trazodone or a salt thereof, and gabapentin or a salt or prodrug thereof, said combination having a synergistic effect in the treatment of pain.

Abstract: Disclosed is a refillable cosmetic container including a container body provided with a main body of which an one side is opened; a refillable container part detachably coupled to the main body and in which a cosmetic liquid is stored; a support part coupled to the other side of the main body; and a pumping driving part coupled to the support part to discharge the cosmetic liquid stored in the refillable container part to the outside of the refillable container part, wherein the refillable container part includes a refillable container body detachably coupled to the main body and a shifter part detachably coupled to the refillable container body and penetrated with a tube member of the pumping driving part, and a film is provided between the refillable container body and the main body to be easily separated when the refillable container body is separated from the main body.

Abstract: A medical bandaging and tourniquet system for use in dressing puncture wounds is provided. The medical bandaging and tourniquet system includes a primary dressing, a secondary dressing, a band, a tightening buckle, a retaining clip, and a tightening rod. The primary dressing serves as a main wrapping bandage that mounts the secondary dressing and tourniquet components together. The secondary dressing removably attaches to the primary dressing and serves as a bandage that can be installed onto minor wounds. The band connects to the primary dressing, serving as an elastic tourniquet band. The tightening buckle and the retaining clip are connected to the primary dressing. The tightening rod is positioned between the tightening buckle and the retaining clip. The primary dressing straps tightly along a wound though the tightening buckle. The strap is further compressed by turning the tightening rod. The tightening rod can then be secured to the retaining clip.

Abstract: The invention provides compositions and methods useful for the treatment and prevention of conditions associated with short telomere length.

Abstract: Methods and devices and clamps for separating a hub from a rotor of a rotor/hub assembly, including a platform having a top portion to receive the rotor and an opening to allow a pusher from a jack or press to pass through the opening, and a set of clamps configured to hold the rotor in a fixed position with respect to the platform while the pusher pushes through the opening to contact the hub to separate the hub from the rotor. The clamps are generally C-shaped and devoid of moving parts and slip inwardly upon the platform to hold the rotor while the pusher pushes upward to release the hub from the rotor, and the clamps have a slot to allow the clamps to rotate and store out of position in a non-use mode.

Abstract: A guidance system for a slide assembly for a mold for a plastic and/or silicone processing machine is presented. The processing machine comprises at least two mold halves with at least one slide assembly mounted to at least one mold half. The slide assembly is movable parallel to the plane of the parting line of the two mold halves and generally perpendicular to the direction of the plane of separation of the two mold halves after a part has been formed. The slide assembly comprises a carrier for holding cavity forming parts, gibs that secure the carrier to the mold half, and a series of rollers arranged to engage with the carrier such that the rollers roll with the movement of the carrier parallel to the parting line of the two mold halves. The rollers do not bear any of the compression force used to press the two mold halves together.

Abstract: Disclosed is a container for mixing different types of cosmetics including a first container part in which a first cosmetic content is stored; a second container part detachably coupled to the first container part and in which a second cosmetic content is stored; and a mixing part coupled to the second container part to be elevated and ejects the second cosmetic content into the first container part to mix the first cosmetic content and the second cosmetic content, wherein the first container part and the second container part are independently separated from each other, and when the first container part and the second container part are coupled to each other to press the mixing part, the second cosmetic content stored in the second container part is introduced into the first container part so that the first cosmetic content and the second cosmetic content are mixed with each other.

Abstract: The present invention relates to the 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta (GSK-3?) inhibitors and to their use in the treatment of GSK-3?-related disorders such as, for example, (i) insulin-resistance disorders; (ii) neurodegenerative diseases; (iii) mood disorders; (iv) schizophrenic disorders; (v) cancerous disorders; (vi) inflammation, (vii) osteoporosis, (viii) cardiac hypertrophy, (ix) epilepsies and (x) neuropathic pain.

Abstract: The present invention provides an in vitro method for obtaining data useful for diagnosing a cardiomyopathy in a human subject, wherein the method comprises using, as an indicator, the expression levels, obtained from a biological sample isolated from the human subject, preferably a plasma sample, of one or more of the following miRNAs miR-721 and/or miR-155); and obtaining a result of the method by comparing the expression levels of said one or more miRNAs with a reference value or with the expression levels of a control, indicator of the absence of cardiomyopathy.

Abstract: The invention relates to peptides capable of inhibiting neuronal exocytosis and to products comprising such peptides, in particular pharmaceutical and cosmetic products useful for ameliorating skin conditions, disorders and/or diseases mediated by neuronal exocytosis, such as wrinkles, excessive perspiration, pruritus, cutaneous inflammation, dermatitis, atopia, psoriasis, vascular hyperreactivity, rosacea, acne, hair growth, wound healing, calluses, warts, or sensitive skin conditions, such as ulcers and lesions on the skin.