Patents Assigned to Farmaceutici Geymonat Sud S.p.A.
  • Process for preparing 1,4-bis-piperonylpiperazine and similar compounds
    Patent number: 4264770
    Abstract: Compounds of general formula: ##STR1## particularly 1,4-bis-piperonylpiperazine, are obtained with high yields by reacting equimolar quantities of piperazine and of a chloride Ar--CH.sub.2 --Cl in the presence of water, under agitation, and in the presence of a cationic surfactant.
    Type: Grant
    Filed: April 27, 1979
    Date of Patent: April 28, 1981
    Assignee: Farmaceutici Geymonat Sud S.P.A.
    Inventors: Giancarlo Scapini, Gian P. Gardini, Armando Raimondi, Placido Poidomani
  • Method of making a fominoben/theophylline complex
    Patent number: 4246407
    Abstract: Fominoben/theophylline complex is disclosed having the formula: ##STR1## In pharmaceutical oral preparations (dragees or syrup) the complex is usable in dosages corresponding to those of Fominoben hydrochloride, without exhibiting, however, a bitter nauseating taste.The complex is prepared by refluxing a solution of Fominoben hydrochloride and theophylline sodium salt in equimolar proportions in an alcoholic solvent while at the same time dehydrating the reflux stream.
    Type: Grant
    Filed: August 8, 1979
    Date of Patent: January 20, 1981
    Assignee: Farmaceutici Geymonat Sud S.p.A.
    Inventors: Giancarlo Scapini, Armando Raimondi, Placido Poidomani
  • Process for preparing p-chlorophenoxy-acetyl-piperonylpiperazine hydrochloride
    Patent number: 4225714
    Abstract: The subject compound, otherwise known as Fipexidum hydrochloride, is obtained by reacting the chloride of p-chlorophenoxyacetic acid with 1,4-bis-piperonylpiperazine, preferably in benzene solution under reflux conditions in the presence of a base such as sodium bicarbonate. The advantages of the process are low cost and high overall conversion due to easy recovery and recycle of relevant substances.
    Type: Grant
    Filed: April 27, 1979
    Date of Patent: September 30, 1980
    Assignee: Farmaceutici Geymonat Sud S.p.A.
    Inventors: Gian P. Gardini, Giancarlo Scapini, Armando Raimondi, Placido Poidomani
  • Pharmaceutical fominoben/theophylline complex
    Patent number: 4197300
    Abstract: Fominoben/theophylline complex is disclosed having the formula: ##STR1## In pharmaceutical oral preparation (dragees or syrup) having respiratory analeptic or anti-tussive usage the complex is usable in dosages corresponding to those of Fominoben hydrochloride, without exhibiting, however, a bitter nauseating taste.The complex is prepared by refluxing a solution of Fominoben hydrochloride and theophylline sodium salt in equimolar proportions in an alcoholic solvent while at the same time dehydrating the reflux stream.
    Type: Grant
    Filed: March 8, 1979
    Date of Patent: April 8, 1980
    Assignee: Farmaceutici Geymonat Sud S.p.A.
    Inventors: Giancarlo Scapini, Armando Raimondi, Placido Poidomani