Patents Assigned to Febit Holding GmbH
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Publication number: 20140024554Abstract: The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject.Type: ApplicationFiled: December 28, 2011Publication date: January 23, 2014Applicant: febit Holding GmbHInventors: Andreas Keller, Markus Beier
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Publication number: 20130331290Abstract: The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of a lung disease in a biological sample from a patient. Further, the present invention relates to means for diagnosing and/or prognosing of a lung disease comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of a lung disease based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for a lung disease. In addition, the present invention relates to a kit for diagnosing and/or prognosing of a lung disease comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for a lung disease and optionally at least one reference and/or algorithm or mathematical function comprised on at least one data carrier.Type: ApplicationFiled: January 26, 2012Publication date: December 12, 2013Applicant: febit Holding GmbHInventors: Andreas Keller, Markus Beier
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Publication number: 20130331278Abstract: The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject.Type: ApplicationFiled: December 28, 2011Publication date: December 12, 2013Applicant: febit Holding GmbHInventors: Andreas Keller, Markus Beier, Valesca Boisguerin, Eckart Meese, Petra Leidinger
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Publication number: 20130157883Abstract: The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of an acute coronary syndrome in a blood sample from a human. Further, the present invention relates to means for diagnosing and/or prognosing of an acute coronary syndrome comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of an acute coronary syndrome based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome compared to a reference. In addition, the present invention relates to a kit for diagnosing and/or prognosing of an acute coronary syndrome comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome and at least one reference.Type: ApplicationFiled: April 19, 2011Publication date: June 20, 2013Applicant: FEBIT HOLDING GMBHInventors: Andreas Keller, Peer F. Stähler, Markus Beier, Benjamin Meder, Hugo A. Katus, Wolfgang Rottbauer
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Publication number: 20130053264Abstract: MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.Type: ApplicationFiled: December 30, 2010Publication date: February 28, 2013Applicant: FEBIT HOLDING GMBHInventors: Andreas Keller, Eckart Meese, Anne Borries, Markus Beier
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Publication number: 20130053263Abstract: MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.Type: ApplicationFiled: December 30, 2010Publication date: February 28, 2013Applicant: FEBIT HOLDING GMBHInventors: Andreas Keller, Eckart Meese, Anne Borries, Markus Beier
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Publication number: 20130035251Abstract: MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.Type: ApplicationFiled: December 30, 2010Publication date: February 7, 2013Applicant: febit holding GmbHInventors: Andreas Keller, Eckart Meese, Anne Borries, Markus Beier
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Publication number: 20120309645Abstract: The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.Type: ApplicationFiled: February 7, 2011Publication date: December 6, 2012Applicant: FEBIT HOLDING GMBHInventors: Andreas Keller, Matthias Scheffler, Markus Beier
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Publication number: 20120196757Abstract: The invention relates to methods and devices for preparing synthetic nucleic acids.Type: ApplicationFiled: April 6, 2012Publication date: August 2, 2012Applicant: FEBIT HOLDING GMBHInventors: Peer Stähler, Raphael Carapito
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Publication number: 20120157337Abstract: The present invention provides novel methods for diagnosing diseases based on the determination of specific miR-NAs that have altered expression levels in disease states compared to healthy controls.Type: ApplicationFiled: June 7, 2010Publication date: June 21, 2012Applicant: FEBIT HOLDING GMBHInventors: Andreas Keller, Eckart Meese, Anne Borries, Peer Friedrich Staehler, Markus Beier
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Publication number: 20120157336Abstract: The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.Type: ApplicationFiled: June 7, 2010Publication date: June 21, 2012Applicant: FEBIT HOLDING GMBHInventors: Andreas Keller, Eckart Meese, Anne Borries, Peer Friedrich Staehler, Markus Beier
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Patent number: 8173368Abstract: The invention relates to methods and devices for preparing synthetic nucleic acids.Type: GrantFiled: August 23, 2007Date of Patent: May 8, 2012Assignee: febit holding GmbHInventors: Peer Staehler, Raphael Carapito
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Publication number: 20120108462Abstract: The present invention provides novel methods for diagnosing diseases based on the determination of specific miRNAs that have altered expression levels in disease states compared to healthy controls.Type: ApplicationFiled: June 7, 2010Publication date: May 3, 2012Applicant: FEBIT HOLDING GMBHInventors: Andreas Keller, Eckart Meese, Anne Borries, Markus Beier
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Publication number: 20120071327Abstract: The invention relates to a method for acquisition of genetic information, in particular for personalized medicine.Type: ApplicationFiled: December 11, 2009Publication date: March 22, 2012Applicant: FEBIT HOLDING GMBHInventors: Peer F. Staehler, Cord F. Staehler, Markus Beier, Mark S. Chee, Nadine Schracke
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Publication number: 20120045771Abstract: The invention relates to a method for isolation of target molecules from a nucleic acid population.Type: ApplicationFiled: December 11, 2009Publication date: February 23, 2012Applicant: FEBIT HOLDING GMBHInventors: Markus Beier, Peer F. Staehler, Cord F. Staehler, Daniel Summerer, Jack T. Leonard, Stephan Bau, Anthony Caruso, Nadine Schracke, Andreas Keller, Helmut Hanenberg, Olaf Eckermann
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Publication number: 20110092380Abstract: The invention relates to improved molecular-biological processing equipment and an improved method of processing biological samples. The invention combines the provision of biologically functional molecules such as nucleic acids and peptides and of derivatives or analogs of these two classes of molecules in miniaturized flow cells with the sequential addition of reagents or fluids and serves for the processing of biological samples, such as proteins, nucleic acids, biogenic small molecules such as e.g. metabolites, viruses or cells, which for this purpose are introduced into the miniaturized flow cells.Type: ApplicationFiled: December 31, 2007Publication date: April 21, 2011Applicant: FEBIT HOLDING GMBHInventors: Peer Stahler, Markus Beier, Cord Stahler, Daniel Summerer, Mark Matzas, Sonja Vorwerk
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Patent number: 7901886Abstract: The invention relates to an extraction method for isolating target molecules from a sample using a microfluidic carrier.Type: GrantFiled: November 28, 2007Date of Patent: March 8, 2011Assignee: Febit Holding GmbHInventors: Cord F. Staehler, Peer F. Staehler, Manfred Mueller
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Publication number: 20100256012Abstract: The invention relates to an extraction method for isolating target molecules from a sample with the help of a molecule library.Type: ApplicationFiled: November 24, 2008Publication date: October 7, 2010Applicant: FEBIT HOLDING GMBHInventors: Markus Beier, Stephan Bau, Daniel Summerer, Mark Matzas, Peer F. Staehler
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Patent number: 7790369Abstract: The invention relates to a method for producing polymers, in particular synthetic nucleic acid double strands of optional sequence, comprising the steps: (a) providing a support having a surface area which contains a plurality of individual reaction areas, (b) location-resolved synthesizing nucleic acid fragments each having different base sequences in several of the individual reaction areas, and (c) detaching the nucleic acid fragments from individual reaction areas.Type: GrantFiled: June 6, 2003Date of Patent: September 7, 2010Assignee: febit holding GmbHInventors: Peer F. Stähler, Cord F. Stähler, Manfred Müller
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Publication number: 20100216648Abstract: The invention relates to methods and devices for preparing synthetic nucleic acids.Type: ApplicationFiled: February 19, 2010Publication date: August 26, 2010Applicant: FEBIT HOLDING GMBHInventors: Peer F. STAEHLER, Raphael CARAPITO, Cord F. STAEHLER, Mark MATZAS, Jack T. LEONARD, Joachim JAEGER, Markus BEIER