Patents Assigned to Ferrer International, S.A.
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Patent number: 9180200Abstract: The invention provides pharmaceutical stable semisolid topical compositions comprising between 0.2 to 5% of a des-fluoroquinolone compound, and a suitable carrier to manufacture an ointment or a cream.Type: GrantFiled: October 16, 2009Date of Patent: November 10, 2015Assignee: FERRER INTERNATIONAL, S.A.Inventors: Cristina Tarragó, Benjamin Santos, Manuel Raga, Antonio Guglietta
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Patent number: 8338436Abstract: The present invention relates to an amorphous form of N-{2-Fluoro-5-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a]pyrimidin-7-yl]-phenyl}-N-methyl-acetamide, methods for its preparation, its use as a therapeutically active agent and pharmaceutical compositions comprising the novel form.Type: GrantFiled: November 7, 2007Date of Patent: December 25, 2012Assignee: Ferrer International, S.A.Inventors: Luis Anglada, Albert Palomer, Antonio Guglietta
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Patent number: 8273753Abstract: The present invention relates to a method of treating anxiety, epilepsy, sleep disorders, and insomnia, for inducing sedation-hypnosis, anesthesia, and muscle relaxation, and for modulating the necessary time to induce sleep and its duration, which comprises administering a therapeutically effective amount of Polymorph B of N-{2-Fluoro-5-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a]pyrimidin-7-yl]-phenyl}-N-methyl-acetamide characterized by a powder X-Ray diffraction pattern containing specific peaks at 2?=7.1° (±0.1°) and 21.4° (±0.1°) to a patient in need thereof.Type: GrantFiled: May 25, 2011Date of Patent: September 25, 2012Assignee: Ferrer International, S.A.Inventors: Luis Anglada, Albert Palomer, Antonio Guglietta
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Publication number: 20120059053Abstract: This invention provides new 2,3-dihydro-benzofuran compounds, their use for the treatment or prevention of melatoninergic disorders and its compositions.Type: ApplicationFiled: October 23, 2008Publication date: March 8, 2012Applicant: FERRER INTERNATIONAL, S.A.Inventors: José L. Falcó, Albert Palomer, Antonio Guglietta
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Patent number: 7943611Abstract: The invention provides novel imidazo[1,2-a]pyridin-3-yl-acetic acid hydrazides of formula (I) wherein R1, R2 and R3 have different meanings, and pharmaceutically acceptable salts, polymorphs, hydrates, tautomers, solvates and stereoisomers thereof. Compounds of formula (I) are useful for treating or preventing, in a human or non-human mammal, diseases associated with GABAA receptors modulation, anxiety, epilepsy, sleep disorders including insomnia, and for inducing sedation-hypnosis, anesthesia, sleep and muscle relaxation. The invention also provides synthetic processes for preparing said compounds.Type: GrantFiled: December 21, 2006Date of Patent: May 17, 2011Assignee: Ferrer International, S.A.Inventors: José Luís Falcó, Albert Palomer, Antonio Guglietta
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Publication number: 20100261691Abstract: The invention relates to the technical field of anti-inflammatory compounds, specifically those of a steroid nature, in particular to a new amorphous form of a nitrooxy derivative of a corticosteroid, its pharmaceutical formulations and its use in the treatment or prevention of diseases or symptoms of the skin or mucous membranes.Type: ApplicationFiled: October 23, 2008Publication date: October 14, 2010Applicants: FERRER INTERNATIONAL, S.A., NICOX SAInventors: Luis Anglada, Carlos Albet, Antonio Guglietta
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Publication number: 20100137339Abstract: The present invention relates to an amorphous form of N-{2-Fluoro-5-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a]pyrimidin-7-yl]-phenyl}-N-methyl-acetamide, methods for its preparation, its use as a therapeutically active agent and pharmaceutical compositions comprising the novel form.Type: ApplicationFiled: November 7, 2007Publication date: June 3, 2010Applicant: FERRER INTERNATIONAL, S.A.Inventors: Luis Anglada, Albert Palomer, Antonio Guglietta
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Publication number: 20090264448Abstract: The invention provides novel pyrazolo[1,5-a]pyrimidines which are useful for treating or preventing anxiety, epilepsy and sleep disorders including insomnia, and for inducing sedation-hypnosis, anesthesia, sleep and muscle relaxation.Type: ApplicationFiled: August 2, 2007Publication date: October 22, 2009Applicant: Ferrer International, S.A.Inventors: Luis Anglada, Albert Palomer, Antonio Guglietta
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Publication number: 20090264393Abstract: The invention relates to new steroids nitrooxyderivatives, to topical pharmaceutical formulations thereof, and their use for treating skin or mucosal membrane diseases or disorders. These new steroids nitrooxyderivatives have an improved pharmacological activity and enhanced local tolerability.Type: ApplicationFiled: June 26, 2009Publication date: October 22, 2009Applicants: Nicox S.A., Ferrer International S.A.Inventors: Francesca BENEDINI, Ennio ONGINI, Antonio GUGLIETTA, Daniel PALOP, Marta PRINCEP
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Publication number: 20080206328Abstract: The present invention relates to hypocholesterolemic compositions comprising statins plus antiflatulent agents. In particular the compositions of the present invention comprise a statin selected from the group consisting of atorvastatin, cerivastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin, whether in free form or as pharmaceutically acceptable salts and hydrates thereof, plus an antiflatulent agent. selected from the group consisting of simethicone and dimethicone. The combination of statins plus antiflatulent agents is useful in the prevention and management of flatulence caused by statins.Type: ApplicationFiled: February 2, 2005Publication date: August 28, 2008Applicant: Ferrer International, S.A.Inventors: Marta Guerrero, Anna Orriols, Manuel M. Raga, Antonio Guglietta
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Publication number: 20050143395Abstract: The process consists in condensing (2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a]pyrimidin-3-yl)-acetaldehyde with 6-fluoro-3-piperidinyl)-1,2-benzisoxazole to yield the intermediate enamine, 3-{2-[4-(6-fluorobenzo[d]isoxazole-3-yl)-piperidin-1-yl]vinyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2,-a]pyrimidin-4-one followed by reduction of such an enamine.Type: ApplicationFiled: March 3, 2003Publication date: June 30, 2005Applicant: Ferrer International S.A.Inventors: Rafael Foguet, Jorge Ramentol, Diego Fernandez-Cano, Miguel Armengol, Francesc Camps, Juan Sallares, Ines Petschen, Mireia Pasto, Esther Gordo
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Patent number: 4603134Abstract: A piperazine derivative is disclosed of formula (I): ##STR1## and the non-toxic addition salts thereof, along with a process for preparation, pharmaceutical composition, and method of treating conditions characterized by histamine activity.Type: GrantFiled: January 11, 1985Date of Patent: July 29, 1986Assignee: Ferrer International, S.A.Inventors: Rafael Foguet, Santiago Gubert, Manuel Raga, Aurelio Sacristan, Jose A. Ortiz
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Patent number: 4600780Abstract: New N-cyano-formamidine are disclosed of the formula I: ##STR1## wherein R is 2-[[(5-methyl-1H-Imidazol-4-yl)methyl]thio]ethyl, 2-[[[5-[dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl, 2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl or 3-[3-(1-piperidinylmethyl)phenoxy]propyl, as well as a process for its production, and pharmaceutical preparations containing the same. The compounds possess histamine--induced gastric acid secretion--inhibiting activity, and are indicated for use in the treatment of peptic ulcer and other pathologies caused or stimulated by gastric acidity.Type: GrantFiled: March 20, 1984Date of Patent: July 15, 1986Assignee: Ferrer International, S.A.Inventors: Rafael Foguet, Luis Anglada, Manuel M. Raga, Jose A. Ortiz, Aurelio Sacristan, Jose M. Castello