Abstract: Preparation of renin inhibitors based on the structure of natural renin substrate at residues 6 to 13 from the amino terminal thereof, the inhibitors being polypeptide analogues having in particular an isosteric non-peptide link corresponding to the 10, 11 peptide link of the substrate, and preparation of dipeptide analogues.
Type:
Grant
Filed:
August 5, 1981
Date of Patent:
January 3, 1984
Assignee:
Ferring Pharmaceuticals Limited
Inventors:
Michael Szelke, David M. Jones, Allan Hallett