Abstract: A process for the production of optically enriched (R)- or (S)-albuterol or (R)- or (S)-albuterol salts by the resolution of a novel ketal derivative 2-(N-t-butylamino)-1-(+2,2-dimethyl-1,2-benzodioxin-6-yl) ethanol, with a chiral tartaric acid derivative.
Type:
Grant
Filed:
November 13, 2000
Date of Patent:
April 2, 2002
Assignee:
Fine Chemical Corporation Limited
Inventors:
Anne Stevens, Roger Hunter, Luigi Nassimbeni, Mino Caira, Janet Scott, Rainer Clauss, Joanne Gibson, Tarron Grimmbacher