Patents Assigned to Firmenich Incorporated
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Publication number: 20240156140Abstract: The present disclosure generally provides amide compounds, including cinnamic acid amides, and the use of such compounds and related compounds as flavor modifiers. In some aspects, the disclosure provides compositions that include such amide compounds, such as compositions that include such amide compounds and one or more additional compounds, such as a sweetener, a salt, a glutamate, an arginate, a purinic ribonucleotide, and the like. In some other aspects, the disclosure provides methods of reducing or eliminating the amount of sweetener, salt, glutamate, or arginate in a food or beverage product.Type: ApplicationFiled: April 20, 2022Publication date: May 16, 2024Applicant: Firmenich IncorporatedInventors: Joseph R. FOTSING, Melissa Sue WONG
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Publication number: 20240114942Abstract: The present disclosure generally provides compounds that antagonize certain T2R taste receptors, including related uses, methods, and compositions for the reduction of bitter taste and/or the enhancement of sweet taste. In certain aspects, the disclosure provides flavored articles or flavored compositions comprising such compounds, as well as uses of such compounds to reduce the bitter taste and/or enhance the sweet taste of such flavored articles or flavored compositions.Type: ApplicationFiled: November 10, 2023Publication date: April 11, 2024Applicant: Firmenich IncorporatedInventors: Joseph R. Fotsing, Andrew Patron, Guy Servant, Lan Zhang, Mark Williams, Qing Chen, Kenneth Simone, Vincent Darmohusodo, Chad Priest, Melissa S. Wong, Thomas Brady
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Patent number: 11945813Abstract: Disclosed herein are 5-Substituted 4-amino-1H-benzo[c][1,2,6]thiadiazine 2,2-dioxide compounds useful as sweet flavor modifiers. Also disclosed herein are ingestible compositions that include one or more of these compounds in combination with a natural or artificial sweetener.Type: GrantFiled: August 6, 2019Date of Patent: April 2, 2024Assignee: FIRMENICH INCORPORATEDInventors: Joseph R. Fotsing, Catherine Tachdjian, Guy Servant, Brett Weylan Ching, Timothy Davis
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Publication number: 20240058238Abstract: The present disclosure generally relates to coolness-modifying compositions that enhance the cooling effect of cooling compounds, such as menthol, cubebol, and the like. In some aspects, the disclosure provides uses of such coolness-modifying compositions to cooling effect of cooling compounds. In some other aspects, the disclosure provides compositions (such as comestible compositions or oral care compositions), which comprise a cooling compound (for example, menthol, cubebol, and the like) and a coolness-modifying composition of the present disclosure. In some embodiments, such compositions are in the form of a food product, a beverage product, or an oral care product, such as a toothpaste, a mouthwash, a tooth-whitening composition, a chewing gum, a dentifrice, and the like. In some other embodiments, such compositions are in the form of a body care product, such as a cosmetic product, a skin care product, or a hair care product.Type: ApplicationFiled: January 6, 2022Publication date: February 22, 2024Applicant: Firmenich IncorporatedInventors: Chad PRIEST, Qing-Bo OUYANG, Bharani ASHOKAN, Jan Thomas HAINES, Patrice MERCERET, Parizad MITHAIWALLA, Florence VIGOUROUX, Pauline LEDERREY
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Patent number: 11871772Abstract: The present disclosure generally provides compounds that antagonize certain T2R taste receptors, including related uses, methods, and compositions for the reduction of bitter taste and/or the enhancement of sweet taste. In certain aspects, the disclosure provides flavored articles or flavored compositions comprising such compounds, as well as uses of such compounds to reduce the bitter taste and/or enhance the sweet taste of such flavored articles or flavored compositions.Type: GrantFiled: August 8, 2019Date of Patent: January 16, 2024Assignee: Firmenich IncorporatedInventors: Joseph R. Fotsing, Andrew Patron, Guy Servant, Lan Zhang, Mark Williams, Qing Chen, Kenneth Simone, Vincent Darmohusodo, Chad Priest, Melissa S. Wong, Thomas Brady
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Patent number: 11758933Abstract: Disclosed herein are compounds having structural Formula (I), or salts thereof. These compounds are useful as sweet tasting agents and/or sweetness enhancers. Also disclosed are compositions comprising the present compounds and methods of increasing the sweet taste of ingestible compositions. Furthermore, methods for preparing the compounds are also disclosed.Type: GrantFiled: March 24, 2021Date of Patent: September 19, 2023Assignee: Firmenich IncorporatedInventors: Andrew Patron, Rama Manam, Justin Colquitt, Nicole Servant, Chris Edano Noriega, Jeffrey R. Hammaker, Nicole Gonsalves, Tanya Ditschun
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Publication number: 20230028760Abstract: The present disclosure generally relates to various formulations and uses of the compound: 3-((4-amino-2,2-dioxo-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2,2-dimethyl-N-propylpropanamide, which is also referred to herein a “TM1” and comestibly acceptable salts thereof. In some aspects, the disclosure provides compositions that include TM1, or a comestibly acceptable salt thereof. In some embodiments, the compositions are ingestible compositions, including, but not limited to, packaged food and beverage products and tabletop sweeteners. In some aspects, the disclosure provides certain compositions that include such flavanone derivatives, such as compositions that include such flavanone derivatives and one or more other sweeteners. In some other aspects, the disclosure provides methods of reducing the caloric content of a sweetened article, such as a sweetened food or beverage product.Type: ApplicationFiled: December 3, 2020Publication date: January 26, 2023Applicant: Firmenich IncorporatedInventors: Dattatreya BANAVARA, Srinivasan SUBRAMANIAN, Tanya DITSCHUN, Andrew PATRON, Angela DI PIETRO
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Publication number: 20230025283Abstract: The present disclosure generally relates to various formulations and uses of the compound: N-(heptan-4-yl)benzo[d] [1,3]dioxole-5-carboxamide, which is also referred to herein a “TM1” and comestibly acceptable salts thereof. In some aspects, the disclosure provides compositions that include TM1, or a comestibly acceptable salt thereof. In some embodiments, the compositions are ingestible compositions, including, but not limited to, packaged food and beverage products. In some other aspects, the disclosure provides methods of reducing the caloric content of a flavored article, for example, by reducing the amount of caloric sweeteners, fatty products (such as cheese). In some other aspects, the disclosure provides methods of reducing the amount of monosodium glutamate (MSG).Type: ApplicationFiled: December 7, 2020Publication date: January 26, 2023Applicant: Firmenich IncorporatedInventors: Andrew PATRON, Tanya DITSCHUN, Imad FARHAT, Yukiko ANDO OVESEN, Srinivasan SUBRAMANIAN
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Publication number: 20230000122Abstract: The present disclosure generally relates to various formulations and uses of the compound: 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)-imidazolidine-2,4-dione, which is also referred to herein a “TM1” and comestibly acceptable salts thereof. In some aspects, the disclosure provides compositions that include TM1, or a comestibly acceptable salt thereof. In some embodiments, the compositions are ingestible compositions, including, but not limited to, packaged food and beverage products. In some other aspects, the disclosure provides methods of reducing the caloric content of a flavored article, for example, by reducing the amount of caloric sweeteners.Type: ApplicationFiled: December 6, 2020Publication date: January 5, 2023Applicant: Firmenich IncorporatedInventors: Igor BODNAR, Dattatreya BANAVARA, Imad FARHAT, Andrew PATRON, Joseph FOTSING, Tanya DITSCHUN
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Publication number: 20220361547Abstract: The present disclosure generally relates to various formulations and uses of the compound: N-(1-((4-amino-2,2-dioxo-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methyl-propan-2-yl)isonicotinamide, which is also referred to herein a “TM1” and comestibly acceptable salts thereof. In some aspects, the disclosure provides compositions that include TM1, or a comestibly acceptable salt thereof. In some embodiments, the compositions are ingestible compositions, including, but not limited to, packaged food and beverage products and tabletop sweeteners. In some aspects, the disclosure provides certain compositions that include such flavanone derivatives, such as compositions that include such flavanone derivatives and one or more other sweeteners. In some other aspects, the disclosure provides methods of reducing the caloric content of a sweetened article, such as a sweetened food or beverage product.Type: ApplicationFiled: December 8, 2020Publication date: November 17, 2022Applicant: Firmenich IncorporatedInventors: Dattatreya Banavara, Srinivasan SUBRAMANIAN, Tanya DITSCHUN, Andrew PATRON, Angela DI PIETRO
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Publication number: 20220330591Abstract: The present disclosure generally provides compounds that antagonize certain T2R taste receptors, including related uses, methods, and compositions for the reduction of bitter taste and/or the enhancement of sweet taste. In certain aspects, the disclosure provides flavored articles or flavored compositions comprising such compounds, as well as uses of such compounds to reduce the bitter taste and/or enhance the sweet taste of such flavored articles or flavored compositions.Type: ApplicationFiled: August 8, 2019Publication date: October 20, 2022Applicant: Firmenich IncorporatedInventors: Joseph R. Fotsing, Andrew Patron, Guy Servant, Lan Zhang, Mark Williams, Qing Chen, Kenneth Simone, Vincent Darmohusodo, Chad Priest, Melissa S. Wong, Thomas Brady
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Patent number: 11357246Abstract: Disclosed herein are compounds having structural Formula (I), or salts thereof. These compounds are useful as sweet tasting agents and/or sweetness enhancers. Also disclosed are compositions comprising the present compounds and methods of increasing the sweet taste of ingestible compositions. Furthermore, methods for preparing the compounds are also disclosed.Type: GrantFiled: October 27, 2016Date of Patent: June 14, 2022Assignee: FIRMENICH INCORPORATEDInventors: Andrew Patron, Rama Manam, Justin Colquitt, Nicole Servant, Chris Edano Noriega, Jeffrey R. Hammaker, Nicole Gonsalves, Tanya Ditschun
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Patent number: 11339128Abstract: Disclosed herein are 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acid compounds having useful as sweet flavor modifiers. Also disclosed herein are ingestible compositions that include one or more of these compounds in combination with a natural or artificial sweetener.Type: GrantFiled: October 28, 2015Date of Patent: May 24, 2022Assignee: FIRMENICH INCORPORATEDInventors: Goran Petrovic, Joseph R. Fotsing, Guy Servant, Catherine Tachdjian, Donald Karanewsky, Binh Vong, Brant Clayton Boren, Qing Chen, Hong Zhang, Brett Weylan Ching, Stephanie Lapera
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Patent number: 11268952Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.Type: GrantFiled: January 16, 2020Date of Patent: March 8, 2022Assignee: Firmenich IncorporatedInventors: Catherine Tachdjian, Andrew P. Patron, Sara L. Adamski-Werner, Farid Bakir, Qing Chen, Vincent Darmohusodo, Stephen Terrence Hobson, Xiaodong Li, Ming Qi, Daniel H. Rogers, Marketa Rinnova, Guy Servant, Xiao-Qing Tang, Mark Zoller, David Wallace, Amy Xing, Klaus Gubernator
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Patent number: 11060124Abstract: Provided herein include methods of making mogroside compounds, e.g., Compound 1, compositions (for example host cells) for making the mogroside compounds, and the mogroside compounds made by the methods disclosed herein, and compositions (for example, cell lysates) and recombinant cells comprising the mogroside compounds (e.g., Compound 1). Also provided herein are novel cucurbitadienol synthases and the use thereof.Type: GrantFiled: May 2, 2018Date of Patent: July 13, 2021Assignee: Firmenich IncorporatedInventors: Andrew P. Patron, Chris Edano Noriega, Rama R. Manam, Justin Colquitt, Nathan Faber, Helge Zieler, Justin Stege
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Patent number: 11028052Abstract: The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.Type: GrantFiled: September 18, 2019Date of Patent: June 8, 2021Assignee: Firmenich IncorporatedInventors: Lyudmyla Chumakova, Andrew Patron, Chad Priest, Donald Karanewsky, Rachel Kimmich, Brant Clayton Boren, Jeffrey Robert Hammaker, Volodymyr Chumakov, Wen Zhao, Alain Noncovich, Jane Ung
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Patent number: 10953007Abstract: The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formula (I) and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.Type: GrantFiled: May 31, 2018Date of Patent: March 23, 2021Assignee: Firmenich IncorporatedInventors: Chad Priest, Alain Noncovich, Andrew Patron, Jane Ung
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Patent number: 10670584Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions.Type: GrantFiled: September 13, 2018Date of Patent: June 2, 2020Assignee: Firmenich IncorporatedInventors: Mark Zoller, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya, Jon Elliot Adler, Hong Xu, Fernando Echeverri
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Patent number: 10597437Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.Type: GrantFiled: October 16, 2017Date of Patent: March 24, 2020Assignee: Firmenich IncorporatedInventors: Jon Elliot Adler, Xiaodong Li, Lena Luukkonen, Shawn O'Connell, Sergey Zozulya
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Patent number: 10591464Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.Type: GrantFiled: August 28, 2018Date of Patent: March 17, 2020Assignee: Firmenich IncorporatedInventors: Jon E. Adler, Xiaodong Li, Lena Luukkonen, Hong Xu, Fernando Echeverri