Patents Assigned to Flagship Pioneering Innovations V, Inc.
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Patent number: 11166996Abstract: This invention relates generally to viral vectors and viral particles based on Anelloviruses, which can be used to deliver an agent (e.g., an exogenous effector or an endogenous effector, e.g., a therapeutic effector) to a cell (e.g., a cell in a subject to be treated therapeutically). Described herein are anellosomes, anellovectors, and compositions and uses thereof.Type: GrantFiled: June 21, 2019Date of Patent: November 9, 2021Assignee: FLAGSHIP PIONEERING INNOVATIONS V, INC.Inventors: Erica Gabrielle Weinstein, Avak Kahvejian, Simon Delagrave, Nathan Lawrence Yozwiak, Kevin James Lebo, Fernando Martin Diaz, Dhananjay Maniklal Nawandar, Ryan D. Tedstone, Jared David Pitts
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Patent number: 11058698Abstract: Disclosed herein are acylated active agents and methods of their use, e.g., for modulating an autoimmunity marker or for treating an autoimmune disorder.Type: GrantFiled: February 27, 2020Date of Patent: July 13, 2021Assignee: Flagship Pioneering Innovations V, Inc.Inventors: Steven John Taylor, Mi-Jeong Kim, Kathleen Nudel, Timothy F. Briggs, Koji Yasuda, Leonard Buckbinder, Bernard Lanter, Spencer Cory Peck, Cheri Snedeker, Angela She, Jessica Alexander, Anna Liang, Jenny Liu, Dinara Gunasekera, David Arthur Berry, John Patrick Casey, Jr., Amir H. Moarefi
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Patent number: 11059886Abstract: The present invention provides methods for treating inflammatory or autoimmune disease using mGluR8 activators, such as mGluR8 activating antibodies, among others. The invention also features compositions containing mGluR8 activators, methods of diagnosing patients with mGluR8-associated inflammatory or autoimmune disease, and methods of predicting the response of an inflammatory or autoimmune disease or condition in a subject to treatment with mGluR8 activators.Type: GrantFiled: January 30, 2019Date of Patent: July 13, 2021Assignee: Flagship Pioneering Innovations V, Inc.Inventors: Avak Kahvejian, Jordi Mata-Fink, Jonathan Barry Hurov, Chengyi Jenny Shu, George Huck Neubauer, Julian Alexander Stanley
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Publication number: 20210187018Abstract: This disclosure provides, e.g., cytobiologic compositions and methods of use thereof. The cytobiologics can be used, e.g., to deliver a protein or nucleic acid to a target cell.Type: ApplicationFiled: December 7, 2018Publication date: June 24, 2021Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Jacob Rosenblum Rubens, Michael Travis Mee, Nathan Wilson Stebbins, Molly Krisann Gibson, Neal Francis Gordon, Bo Zhang, Kyle Marvin Trudeau, Brigham Jay Hartley, Tamar Rose Putiri, Kiana Mahdaviani, Jagesh Vijaykumar Shah, Michael Connor, Peter Anthony Jones
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Patent number: 11034751Abstract: The present invention provides methods for treating cancer using serotonin receptor inhibitors, such as serotonin receptor inhibitory antibodies, among others. The invention also features compositions containing serotonin receptor inhibitors, methods of diagnosing patients with serotonin receptor-associated cancer, and methods of predicting the response of cancer in a subject to treatment with serotonin receptor inhibitors.Type: GrantFiled: January 30, 2019Date of Patent: June 15, 2021Assignee: Flagship Pioneering Innovations V, Inc.Inventors: Avak Kahvejian, Jordi Mata-Fink, Jonathan Barry Hurov, Chengyi Jenny Shu, George Huck Neubauer, Manuel Andreas Fankhauser, Julian Alexander Stanley
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Patent number: 11013717Abstract: The present invention provides methods for treating cancer using sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump inhibitors, such as SERCA pump inhibitory antibodies, among others. The invention also features compositions containing SERCA pump inhibitors, methods of diagnosing patients with SERCA pump-associated cancer, and methods of predicting the response of cancer in a subject to treatment with SERCA pump inhibitors.Type: GrantFiled: January 31, 2019Date of Patent: May 25, 2021Assignee: Flagship Pioneering Innovations V, Inc.Inventors: Avak Kahvejian, Jordi Mata-Fink, Jonathan Barry Hurov, Chengyi Jenny Shu, Eric Franklin Zhu, Katherine Mary Molloy
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Patent number: 10953027Abstract: Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.Type: GrantFiled: February 27, 2020Date of Patent: March 23, 2021Assignee: Flagship Pioneering Innovations V, Inc.Inventors: Steven John Taylor, John Robert Proudfoot, Mi-Jeong Kim, Kathleen Nudel, Timothy F. Briggs, Afrand Kamali Sarvestani, Leonard Buckbinder, Bernard Lanter, Ferdinand Edward Massari, Koji Yasuda, Spencer Cory Peck, Cheri Snedeker, Diana Le, Jessica Alexander, Anna Liang, Dinara Gunasekera, David Arthur Berry, John Patrick Casey, Jr.
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Publication number: 20210032589Abstract: One aspect of the invention provides an apparatus for isolating one or more subcellular components including a cell disruption reservoir that generates at least one of a phase change, a thermal change, a physical contact force, an ultrasonic frequency, an osmotic change, a pressure change, a photothermal pulse, a magnetic field, an electromagnetic field, an electric field, and an electrical pulse through the reservoir and a separation instrument configured to specifically isolate the subcellular components based on one or more parameters selected from at least one of density, charge/pH, dielectric polarization, magnetic attraction, spectral dispersion, spectral refraction, spectral diffraction, hydrophobicity, hydrophilicity, structure (presence or absence of a structural feature), function (migration), affinity or binding, and pressure.Type: ApplicationFiled: February 8, 2019Publication date: February 4, 2021Applicant: Flagship Pioneering Innovations V, Inc.Inventors: Michael Mee, Adam Rago, Geoffrey von Maltzahn, John Miles Milwid, Jacob Rosenblum Rubens, Michael J. Cima
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Publication number: 20210030467Abstract: One aspect of the invention provides a device for delivering material into a biological tissue. The device includes: a reservoir for the material; and a material delivery unit in connection with the reservoir configured to transfer the material from the reservoir to the tissue. Another aspect of the invention provides an implantable or insertable delivery device for delivery of material across or into a biological tissue in a subject. The device includes: a reservoir for holding the material; and a tissue-penetrating member.Type: ApplicationFiled: February 8, 2019Publication date: February 4, 2021Applicant: Flagship Pioneering Innovations V, Inc.Inventors: Michael Mee, Adam Rago, Geoffrey von Maltzahn, John Miles Milwid, Jacob Rosenblum Rubens, Michael J. Cima
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Patent number: 10683352Abstract: The present invention provides methods for treating cancer using mGluR8 inhibitors, such as mGluR8 inhibitory antibodies and small molecules. The invention also features compositions containing mGluR8 inhibitors, methods of diagnosing patients with mGluR8-associated cancer, and methods of predicting the response of cancer in a subject to treatment with mGluR8 inhibitors.Type: GrantFiled: January 30, 2019Date of Patent: June 16, 2020Assignee: Flagship Pioneering Innovations V, Inc.Inventors: Avak Kahvejian, Jordi Mata-Fink, Jonathan Barry Hurov, Chengyi Jenny Shu, George Huck Neubauer, Julian Alexander Stanley
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Publication number: 20200128856Abstract: Provided herein are methods and compositions for food and feed applications, e.g., for targeting one or more microorganisms resident in a host insect, the modulation resulting in an increase in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the modulating agent described herein may be used to increase the fitness of a variety of insects utilized in human food or animal feed industries.Type: ApplicationFiled: January 24, 2018Publication date: April 30, 2020Applicant: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Christine CEZAR, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
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Publication number: 20200129565Abstract: Provided herein are agents, compositions, and methods for agricultural use, e.g., for altering the level, activity, or metabolism of one or more microorganisms resident in a host nematode or arthropod (e.g., honeybee or silkworm), the alteration resulting in an increase in the fitness of the host. The invention features a composition that includes an agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is beneficial to the host. By promoting favorable microbial levels, microbial activity, microbial metabolism, and/or microbial diversity, the agents described herein may be used to increase the fitness of a variety of beneficial nematodes or arthropods, such as bees and silkworms, utilized in agriculture and commerce.Type: ApplicationFiled: January 24, 2018Publication date: April 30, 2020Applicant: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Jonathan FRIEDLANDER, Christine CEZAR, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
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Publication number: 20200123203Abstract: This invention relates generally to pharmaceutical compositions and preparations of curons and uses thereof.Type: ApplicationFiled: June 13, 2018Publication date: April 23, 2020Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.Inventors: Avak Kahvejian, Erica Gabrielle Weinstein, Nicholas McCartney Plugis, Kevin James Lebo, Fernando Martin Diaz, Dhananjay Maniklal Nawandar
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Publication number: 20200060286Abstract: Provided herein are agents, compositions, and methods useful for animal health, e.g., for altering the level, activity, or metabolism of one or more microorganisms resident in a host insect (e.g., arthropod, e.g., insect, e.g., pathogen vector), the alteration resulting in a decrease in the fitness of the host. The invention features a composition that includes an agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is detrimental to the host. By disrupting microbial levels, microbial activity, microbial metabolism, or microbial diversity, the agents described herein may be used to decrease the fitness of a variety of insects that carry vector-borne pathogens that cause disease in animals.Type: ApplicationFiled: January 24, 2018Publication date: February 27, 2020Applicant: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
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Publication number: 20190367943Abstract: Provided herein are methods and compositions for modulating the fitness of a host invertebrate (e.g., insect, mollusk, or nematode) by altering interactions between the host and one or more micoorganisms resident in the host. The invention features a composition including a modulating agent (e.g., a polypeptide, nucleic acid, small molecule, or combinations thereof) that can induce changes in the host's microbiota in a manner that modulates (e.g., increases or decreases) host fitness. The modulating agent described herein may modulate the fitness of a variety of invertebrates that are important for agriculture, commerce, and/or public health.Type: ApplicationFiled: February 23, 2018Publication date: December 5, 2019Applicant: Flagship Pioneering Innovations V, Inc.Inventors: Ignacio MARTINEZ, Zachary Garo ARMEN, Barry Andrew MARTIN, Maier Steve AVENDANO AMADO
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Patent number: 10457740Abstract: The present invention provides methods for treating cancer using P2RX2 inhibitors, such as P2RX2 inhibitory antibodies, among others. The invention also features compositions containing P2RX2 inhibitors, methods of diagnosing patients with P2RX2-associated cancer, and methods of predicting the response of cancer in a subject to treatment with P2RX2 inhibitors.Type: GrantFiled: September 24, 2018Date of Patent: October 29, 2019Assignee: Flagship Pioneering Innovations V, Inc.Inventors: Avak Kahvejian, Jordi Mata-Fink, Jonathan Barry Hurov, Alexandra Lantermann