Abstract: One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.
Type:
Grant
Filed:
May 28, 2013
Date of Patent:
April 14, 2015
Assignees:
Fluoropharma, Inc., The General Hospital Corporation
Inventors:
David R. Elmaleh, Timothy M. Shoup, Hongning Fu
Abstract: One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.
Type:
Application
Filed:
May 28, 2013
Publication date:
November 28, 2013
Applicants:
Fluoropharma, Inc., The General Hospital Corporation
Inventors:
David R. Elmaleh, Timothy M. Shoup, Hongning Fu
Abstract: One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.
Type:
Grant
Filed:
March 23, 2009
Date of Patent:
May 28, 2013
Assignees:
The General Hosptial Corporation, Fluoropharma, Inc.
Inventors:
David R. Elmaleh, Timothy M. Shoup, Hongning Fu