Patents Assigned to Foamix Pharmaceuticals Ltd.
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Patent number: 9636405Abstract: A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of less than 0.9 or about 0.9 to about 0.7 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.Type: GrantFiled: March 11, 2013Date of Patent: May 2, 2017Assignee: FOAMIX PHARMACEUTICALS LTD.Inventors: Dov Tamarkin, Doron Friedman, Meir Eini, Alex Besonov
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Patent number: 9622947Abstract: The present invention relates to a foamable vehicle or cosmetic or pharmaceutical composition, comprising: (1) an organic carrier, at a concentration of 10% to 70% by weight, wherein said organic carrier concurrently comprises: (i) at least one hydrophobic organic carrier, and (ii) at least one polar solvent; (2) at least one surface-active agent; (3) water; and (4) at least one liquefied or compressed gas propellant at a concentration of 3% to 25% by weight of the total composition. The present invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering the above-mentioned compositions to an afflicted target site.Type: GrantFiled: January 8, 2009Date of Patent: April 18, 2017Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Doron Friedman, Meir Eini, Alex Besonov
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Patent number: 9572775Abstract: A substantially surface active agent-free foamable composition which includes short-chain alcohol, water, polymer, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free foamable composition which includes, water, polymer, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free foamable compositions.Type: GrantFiled: September 17, 2015Date of Patent: February 21, 2017Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Enbal Ziv, Yohan Hazot, David Schuz
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Patent number: 9549898Abstract: A waterless foamable pharmaceutical composition suitable for external administration is disclosed. The composition includes a foamable carrier least one liquefied or compressed gas propellant. The foamable carrier includes at least one liquid oil; at least one silicone and at least one least one stabilizing agent; wherein the stabilizing agent selected from the group consisting of about 0.01% to about 25% by weight of at least one surface-active agent alone or on combination with a foam adjuvant; and about 0% to about 5% by weight of at least one polymeric agent alone or on combination with a foam adjuvant; and mixtures thereof. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.Type: GrantFiled: October 2, 2014Date of Patent: January 24, 2017Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Helena Shifrin, Rita Keynan, Enbal Ziv, Tal Berman, David Schuz, Elana Gazal
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Patent number: 9539208Abstract: The present invention provides a foamable composition for administration to the skin, body surface, body cavity or mucosal surface, e.g., the mucosa of the nose, mouth, eye, ear, respiratory system, vagina or rectum, and methods of using such a composition to treat, alleviate, or prevent a disorder of the skin, body cavity, or mucosal surface. The foamable oil in water nano emulsion composition includes: (a) a nano oil globule system, comprising substantially of sub-micron oil globules; (b) about 0.1% to about 5% by weight of at least one stabilizing agent selected from (i) a non-ionic surfactant, (ii) an ionic surfactant, or (iii) a polymeric agent; and (c) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition, water and optional ingredients. Upon release from an aerosol container, the foamable composition forms and expanded foam suitable for topical administration.Type: GrantFiled: February 4, 2014Date of Patent: January 10, 2017Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Alex Besonov, Meir Eini, Jorge Danziger
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Patent number: 9492412Abstract: The invention relates to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, a gelling agent, an active component selected from the group of urea, hydroxy acid and a therapeutic enhancer and a propellant. The foam further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.Type: GrantFiled: April 22, 2014Date of Patent: November 15, 2016Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Doron Friedman, Meir Eini
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Patent number: 9463919Abstract: A apparatus for delivering a predetermined quantity of content from a pressurized container includes a dispensing assembly which sits on the container and connects with an upper portion of a valve stem of the valve assembly, wherein the dispensing assembly includes a) an actuator cap having a discharge passage, which is open or obstructed and wherein the actuator cap acts as a metering chamber in combination with b) an adaptor which fits inside the cap and also snuggly engages the valve stem. The cap fits snuggly over the adjuster to define a metering chamber which depending on its position can close off the metered chamber or open it to the dispensing conduit\nozzle. When the cap is depressed it pushes down on the adjuster which depresses the valve. The chamber fills, but nothing is released until the upstroke.Type: GrantFiled: February 27, 2015Date of Patent: October 11, 2016Assignee: Foamix Pharmaceuticals Ltd.Inventors: Meir Eini, Tami Winitz, David Schuz
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Patent number: 9439857Abstract: The present invention relates to foamable compositions for treating acne comprising benzoyl peroxide; to a therapeutic kit comprising such compositions; and to a method of treating acne using such compositions.Type: GrantFiled: December 1, 2008Date of Patent: September 13, 2016Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Doron Friedman, David Schuz, Rita Keynan, Tal Berman, Jorge Danziger
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Patent number: 9320705Abstract: This invention relates to foamable compositions that are capable of producing a sensation or sensation modifying effect upon application on a body surface. More particularly the invention relates to foamable pharmaceutical, therapeutic and cosmetic compositions, comprising an active agent, having a sensation or sensation modifying affect on a body surface, upon application. More particularly, the invention relates to foamable compositions comprising: (a) a foamable carrier; (b) at least one sensation or sensation modifying agent, selected from the group of a cooling agent; a warming agent; a relaxing or soothing agent; stimulating or refreshing agent; or mixtures thereof and (c) a propellant at a concentration of about 3% to about 45% by weight of the total composition. The foamable carrier can be an emollient emulsion foamable vehicle, a foamable gel vehicle and can also be a substantially non aqueous foamable vehicle.Type: GrantFiled: January 8, 2009Date of Patent: April 26, 2016Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Meir Eini, Doron Friedman, Ella Zlatkis, David Schuz, Tal Berman
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Patent number: 9265725Abstract: The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.Type: GrantFiled: July 5, 2007Date of Patent: February 23, 2016Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Doron Friedman, Tal Berman, Enbal Ziv, David Schuz
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Patent number: 9211259Abstract: The present invention relates to a therapeutic kit to provide a safe and effective dosage of an antibiotic agent, including an aerosol packaging assembly including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam, wherein the pressurized product comprises a foamable composition including: an antibiotic agent; at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, an organic polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight, a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent, water; and liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.Type: GrantFiled: June 7, 2006Date of Patent: December 15, 2015Assignee: Foamix Pharmaceuticals Ltd.Inventors: Doron Friedman, Alex Besonov, Dov Tamarkin, Meir Eini
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Patent number: 9167813Abstract: A substantially surface active agent-free foamable composition which includes short-chain alcohol, water, polymer, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free foamable composition which includes, water, polymer, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free foamable compositions.Type: GrantFiled: January 27, 2012Date of Patent: October 27, 2015Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Enbal Ziv, Yohan Hazot, David Schuz
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Patent number: 9161916Abstract: The present disclosure teaches unique formulations for topical administration of tetracycline antibiotics, in which the tetracycline antibiotics remain stable.Type: GrantFiled: December 31, 2012Date of Patent: October 20, 2015Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Doron Friedman, Meir Eini, Alex Besonov, Helena Shifrin
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Patent number: 9101662Abstract: The present invention relates to a waterless composition and foam as a vehicle in which an active pharmaceutical or cosmetic agent, when added is stable or stabilized by or its destabilization is impeded by the presence of a modulating agent. The pharmaceutical or cosmetic composition and foam, includes: a waterless solvent, a modulating agent and one or more active pharmaceutical or cosmetic agents. The present invention also relates to a method of treatment administering the waterless composition and foam.Type: GrantFiled: October 3, 2013Date of Patent: August 11, 2015Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Meir Eini, Doron Friedman, Tal Berman, David Schuz
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Patent number: 9072667Abstract: A substantially surface active agent-free and substantially polymeric agent-free foamable composition which includes short-chain alcohol, water, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free and substantially polymeric agent-free foamable composition which includes water, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free and substantially polymeric agent-free foamable composition.Type: GrantFiled: January 27, 2012Date of Patent: July 7, 2015Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Enbal Ziv, Yohan Hazot, David Schuz
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Patent number: 9050253Abstract: The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.Type: GrantFiled: April 7, 2014Date of Patent: June 9, 2015Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Doron Friedman, Meir Eini, Alex Besonov
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Patent number: 8992896Abstract: A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.Type: GrantFiled: August 27, 2014Date of Patent: March 31, 2015Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Elana Gazal, Irakliy Papiashvili, Yohan Hazot, David Schuz, Rita Keynan
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Patent number: 8978936Abstract: A apparatus for delivering a predetermined quantity of content from a pressurized container includes a dispensing assembly which sits on the container and connects with an upper portion of a valve stem of the valve assembly, wherein the dispensing assembly includes a) an actuator cap having a discharge passage, which is open or obstructed and wherein the actuator cap acts as a metering chamber in combination with b) an adaptor which fits inside the cap and also snuggly engages the valve stem. The cap fits snuggly over the adjuster to define a metering chamber which depending on its position can close off the metered chamber or open it to the dispensing conduit\nozzle. When the cap is depressed it pushes down on the adjuster which depresses the valve. The chamber fills, but nothing is released until the upstroke.Type: GrantFiled: July 12, 2011Date of Patent: March 17, 2015Assignee: Foamix Pharmaceuticals Ltd.Inventors: Meir Eini, Tami Winitz, David Schuz
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Patent number: 8945516Abstract: A substantially surface active agent free composition which includes a hydrophobic solvent, and/or a petrolatum, a paraffin wax and/or a fatty alcohol, a fatty acid and/or a wax and/or shea butter, with and without a propellant. A substantially surface active agent free composition, further comprising, a tetracycline antibiotic, or a vitamin D derivative, or one or more other active agents. A method of treatment using a substantially surface active agent free composition.Type: GrantFiled: October 1, 2010Date of Patent: February 3, 2015Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Elana Gazal, Yohan Hazot, David Schuz, Rita Keynan, Nukri Papiashvili
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Patent number: 8900554Abstract: The present invention provides a safe and effective insecticide composition suitable for treating a subject infested with a parasitic anthropode or to prevent infestation by an arthropod. The insecticide composition is a foamable composition, including a first insecticide; at least one organic carrier selected from a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 5%, or about 5% to about 10%; or about 10% to about 20%; or about 20% to about 50% by weight; about 0.1% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent selected from a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; and (5) a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.Type: GrantFiled: February 20, 2012Date of Patent: December 2, 2014Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Doron Friedman, Meir Eini