Patents Assigned to Franklin and Marshall College
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Patent number: 9829183Abstract: A portable copystand is disclosed having a foldable base. A first adjustable arm and a second adjustable arm are provided. The portable copystand also has an ultraviolet light source and a visible spectrum light source.Type: GrantFiled: October 28, 2014Date of Patent: November 28, 2017Assignee: Franklin and Marshall CollegeInventors: J. Kenneth Krebs, Shawn O'Bryhim
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Patent number: 9790305Abstract: The present invention is directed towards a protein-polymer composition having a protein with a site-specifically incorporated unnatural amino acid initiator and a covalently attached polymer.Type: GrantFiled: March 15, 2013Date of Patent: October 17, 2017Assignee: Franklin and Marshall CollegeInventors: Ryan A. Mehl, Krzysztof Matyjaszewski, Saadyah Averick
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Publication number: 20160251467Abstract: The present invention is directed towards a protein-polymer composition having a protein with a site-specifically incorporated unnatural amino acid initiator and a covalently attached polymer.Type: ApplicationFiled: March 15, 2013Publication date: September 1, 2016Applicant: FRANKLIN AND MARSHALL COLLEGEInventors: Ryan A. Mehl, Krzysztof Matyjaszewski, Saadyah Averick
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Publication number: 20160113393Abstract: A portable copystand is disclosed having a foldable base. A first adjustable arm and a second adjustable arm are provided. The portable copystand also has an ultraviolet light source and a visible spectrum light source.Type: ApplicationFiled: October 28, 2014Publication date: April 28, 2016Applicant: FRANKLIN AND MARSHALL COLLEGEInventors: J. Kenneth Krebs, Shawn O'Bryhim
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Patent number: 9243274Abstract: This invention pertains to methods for producing homogeneous recombinant proteins that contain polymer initiators at defined sites. The unnatural amino acid, 4-(2?-bromoisobutyramido)phenylalanine of formula 1, was designed and synthesized as a molecule comprising a functional group further comprising an initiator for an atom-transfer radical polymerization (‘ATRP”) that additionally would provide a stable linkage between the protein and growing polymer. We evolved a Methanococcus jannaschii (Mj) tyrosyl-tRNA synthetase/tRNACUA pair to genetically encode this unnatural amino acid in response to an amber codon. To demonstrate the utility of this functional amino acid, we produced Green Fluorescent Protein with the unnatural amino acid initiator of formula 1 site-specifically incorporated on its surface (GFP-1).Type: GrantFiled: August 5, 2014Date of Patent: January 26, 2016Assignee: Franklin and Marshall CollegeInventors: Ryan A. Mehl, Krzysztof Matyjaszewski, Saadyah Averick
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Publication number: 20150152461Abstract: This invention pertains to methods for producing homogeneous recombinant proteins that contain polymer initiators at defined sites. The unnatural amino acid, 4-(2?-bromoisobutyramido)phenylalanine of formula 1, was designed and synthesized as a molecule comprising a functional group further comprising an initiator for an atom-transfer radical polymerization (‘ATRP”) that additionally would provide a stable linkage between the protein and growing polymer. We evolved a Methanococcus jannaschii (Mj) tyrosyl-tRNA synthetase/tRNACUA pair to genetically encode this unnatural amino acid in response to an amber codon. To demonstrate the utility of this functional amino acid, we produced Green Fluorescent Protein with the unnatural amino acid initiator of formula 1 site-specifically incorporated on its surface (GFP-1).Type: ApplicationFiled: August 5, 2014Publication date: June 4, 2015Applicant: FRANKLIN AND MARSHALL COLLEGEInventors: Ryan A. Mehl, Krzysztof Matyjaszewski, Saadyah Averick
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Patent number: 8816001Abstract: This invention pertains to methods for producing homogeneous recombinant proteins that contain polymer initiators at defined sites. The unnatural amino acid, 4-(2?-bromoisobutyramido)phenylalanine of formula 1, was designed and synthesized as a molecule comprising a functional group further comprising an initiator for an atom-transfer radical polymerization (‘ATRP”) that additionally would provide a stable linkage between the protein and growing polymer. We evolved a Methanococcus jannaschii (Mj) tyrosyl-tRNA synthetase/tRNACUA pair to genetically encode this unnatural amino acid in response to an amber codon. To demonstrate the utility of this functional amino acid, we produced Green Fluorescent Protein with the unnatural amino acid initiator of formula 1 site-specifically incorporated on its surface (GFP-1).Type: GrantFiled: March 7, 2013Date of Patent: August 26, 2014Assignee: Franklin and Marshall CollegeInventors: Ryan A. Mehl, Krzysztof Matyjaszewski, Saadyah Averick
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Patent number: 8673260Abstract: This invention relates to a process for the phase-controlled synthesis of ternary and quaternary mixed-metal sulfide nanoparticles by reacting soft metal ions with hard metal ions in a high-boiling organic solvent in the presence of a complexing and activating ligands to control the reactivity of the metal ions. Ternary and quaternary mixed metal sulfides nanoparticles of copper, sulfur, and iron, aluminum, tin, and silicon are preferred. This invention also relates to the phase controlled preparation of polymorphs of bornite nanoparticles and the phase controlled preparation of stabilized ?- and ?-chalconite nanoparticles.Type: GrantFiled: January 4, 2013Date of Patent: March 18, 2014Assignee: Franklin and Marshall CollegeInventor: Katherine Plass
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Publication number: 20140004591Abstract: The present invention is directed towards a protein-polymer composition having a protein with a site-specifically incorporated unnatural amino acid initiator and a covalently attached polymer.Type: ApplicationFiled: March 15, 2013Publication date: January 2, 2014Applicant: FRANKLIN AND MARSHALL COLLEGEInventors: Ryan A. Mehl, Krzysztof Matyjaszewski, Saadyah Averick
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Publication number: 20130261259Abstract: This invention pertains to methods for producing homogeneous recombinant proteins that contain polymer initiators at defined sites. The unnatural amino acid, 4-(2?-bromoisobutyramido)phenylalanine of formula 1, was designed and synthesized as a molecule comprising a functional group further comprising an initiator for an atom-transfer radical polymerization (‘ATRP”) that additionally would provide a stable linkage between the protein and growing polymer. We evolved a Methanococcus jannaschii (Mj) tyrosyl-tRNA synthetase/tRNACUA pair to genetically encode this unnatural amino acid in response to an amber codon. To demonstrate the utility of this functional amino acid, we produced Green Fluorescent Protein with the unnatural amino acid initiator of formula 1 site-specifically incorporated on its surface (GFP-1).Type: ApplicationFiled: March 7, 2013Publication date: October 3, 2013Applicant: FRANKLIN AND MARSHALL COLLEGEInventors: Ryan A. Mehl, Krzysztof Matyjaszewski, Saadyah Averick
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Publication number: 20130171056Abstract: This invention relates to a process for the phase-controlled synthesis of ternary and quaternary mixed-metal sulfide nanoparticles by reacting soft metal ions with hard metal ions in a high-boiling organic solvent in the presence of a complexing and activating ligands to control the reactivity of the metal ions. Ternary and quaternary mixed metal sulfides nanoparticles of copper, sulfur, and iron, aluminum, tin, and silicon are preferred. This invention also relates to the phase controlled preparation of polymorphs of bornite nanoparticles and the phase controlled preparation of stabilized ?- and ?-chalconite nanoparticles.Type: ApplicationFiled: January 4, 2013Publication date: July 4, 2013Applicant: FRANKLIN AND MARSHALL COLLEGEInventor: FRANKLIN AND MARSHALL COLLEGE
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Patent number: 7776535Abstract: This invention relates, in part, to newly identified polynucleotides, polypeptides, variants and derivatives thereof; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; and uses of the polynucleotides, polypeptides, variants and derivatives. The invention also relates to compositions of orthogonal aminoacyl-tRNA synthetases, and pairs of orthogonal aminoacyl-tRNA synthetases, and orthogonal tRNAs that incorporate fluorinated amino acids into proteins in response to selector codons. The present invention also includes translation biochemistry methods for site-specific incorporation of fluorinated amino acids, for example, 18F- or 19F-labelled amino acids, into proteins or peptides. Such amino acids may be used as an NMR probe for characterizing protein structure, dynamics, and reactivity or for radionuclide imaging (e.g., PET). Fluorinated amino acids may also be used to stabilize proteins or peptides.Type: GrantFiled: February 5, 2007Date of Patent: August 17, 2010Assignee: Franklin and Marshall CollegeInventor: Ryan A. Mehl
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Publication number: 20070218483Abstract: This invention relates, in part, to newly identified polynucleotides, polypeptides, variants and derivatives thereof; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; and uses of the polynucleotides, polypeptides, variants and derivatives. The invention also relates to compositions of orthogonal aminoacyl-tRNA synthetases, and pairs of orthogonal aminoacyl-tRNA synthetases, and orthogonal tRNAs that incorporate fluorinated amino acids into proteins in response to selector codons. The present invention also includes translation biochemistry methods for site-specific incorporation of fluorinated amino acids, for example, 18F- or 19F-labelled amino acids, into proteins or peptides. Such amino acids may be used as an NMR probe for characterizing protein structure, dynamics, and reactivity or for radionuclide imaging (e.g., PET). Fluorinated amino acids may also be used to stabilize proteins or peptides.Type: ApplicationFiled: February 5, 2007Publication date: September 20, 2007Applicant: FRANKLIN AND MARSHALL COLLEGEInventor: Ryan Mehl