Patents Assigned to Fraunhofer USA, Inc.
  • Publication number: 20100227373
    Abstract: Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B(Lic B) were also made and used as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest.
    Type: Application
    Filed: November 24, 2009
    Publication date: September 9, 2010
    Applicant: FRAUNHOFER USA, INC.
    Inventors: Vidadi Yusibov, Vadim Mett, Konstantin Musiychuk
  • Patent number: 7751458
    Abstract: Array comprising high power laser diode comprising laser light emitters, each defining, in a direction perpendicular to direction of propagation of an output laser beam, a fast axis and a slow axis; fast axis collimating means for collimating output laser beams in fast axis direction; and slow axis beam shaping means for collimating or focussing output laser beams in slow axis direction, said slow axis beam shaping means disposed external to said high power laser diode; wherein said laser light emitters are displaced relative to each other in fast axis direction or in fast and slow axis direction by equidistant spacings, respectively; and including optical means for forming output laser beam profile in far field of all laser light emitters consisting of said fast and slow axis collimated or focussed output laser beams arranged adjacently in seamless manner in one or two dimensions with optical fill factor of about 100%.
    Type: Grant
    Filed: November 14, 2008
    Date of Patent: July 6, 2010
    Assignee: Fraunhofer USA, Inc. Center for Laser Technology
    Inventors: Boris Regaard, Thorsten Schmidt, Stefan Heinemann
  • Patent number: 7692063
    Abstract: The present invention provides systems and methods for producing a nucleic acid or protein in transgenic sprouted seedlings or sprouted seedlings engineered to transiently express a nucleic acid or protein of interest. The sprouted seedlings of the invention are grown in a contained, regulatable environment, wherein expression of a pharmaceutically active protein is controlled by an exogenously inducible promoter or a viral promoter. The sprouted seedlings may be eaten live or preferably harvested live to preserve the maximal biological activity of the nucleic acid or protein.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: April 6, 2010
    Assignees: iBio, Inc., Fraunhofer USA, Inc.
    Inventors: Vidadi Yusibov, Vadim Mett, Shailaja Rabindran, Moneim Shamloul, Burt Ensley
  • Patent number: 7683238
    Abstract: The present invention provides systems and methods for producing pharmaceutically active proteins in transgenic sprouted seedlings. The transgenic sprouted seedlings of the invention are grown in a contained, regulatable environment, wherein expression of a pharmaceutically active protein is controlled by an exogenously inducible promoter. The transgenic sprouted seedlings may be eaten live or preferably harvested live to preserve the maximal biological activity of the pharmaceutically active protein.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: March 23, 2010
    Assignee: iBio, Inc. and Fraunhofer USA, Inc.
    Inventors: Burt D. Ensley, Vidadi Yusibov
  • Publication number: 20090276757
    Abstract: Systems, computer program products, and methods for extracting, evaluating, and updating the architecture of a software system are provided. In an embodiment, the method operates by defining the planned architecture for the system and extracting the implemented software code architecture from the source code of the system. The method compares the actual architecture to the planned architecture defined to identify architectural deviations, and suggested changes to the architecture are identified based upon the architectural deviations. The modeled code architecture and defined planned architecture information enables verification and determination of whether a software system's source code conforms to the intended structure of the system. The code architecture and planned architecture comparison also enables analysis and display of the effects that changes to source code may have on the structure of a software system.
    Type: Application
    Filed: April 30, 2008
    Publication date: November 5, 2009
    Applicants: Fraunhofer USA, Inc., Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung e.V
    Inventors: Mikael Lindvall, Dirk Muthig, Patricia Costa, Jens Knodel
  • Patent number: 7491509
    Abstract: The present invention provides trans-complementation systems for expressing gene products in plants. In general, the invention provides systems including a carrier vector and a producer vector, both based on plant viruses. The producer vector is defective for at least one function needed for successful systemic infection of a plant, e.g., replication, cell-to-cell movement, or long distance movement. The carrier vector supplies the missing function in trans. Certain producer vectors lack a functional coat protein coding sequence, in which case the corresponding producer vector supplies coat protein in trans. The invention also provides novel plant viral vectors and methods of use, e.g., to produce polypeptides or active RNAs in plants.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: February 17, 2009
    Assignee: Fraunhofer USA, Inc.
    Inventors: Oleg Fedorkin, Shailaja Rabindran, Vidadi Yusibov
  • Patent number: 7147810
    Abstract: Wetted thin diamond films which are drapable are described. The films are mounted on various substrates and used as windows for electromagnetic radiation or form a surface coating on an article of manufacture.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: December 12, 2006
    Assignees: Fraunhofer USA, Inc., Board of Trustees of Michigan State University
    Inventors: Donnie K. Reinhard, Jes Asmussen, Michael F. Becker, Timothy A. Grotjohn, Thomas Schuelke, Roger Booth
  • Patent number: 7065105
    Abstract: An apparatus for shaping the output beam of a strip of lasers, or an array of such strips, comprising a first reflective member including at least a first reflective element for deflecting a first portion of the output beam in a first direction oriented at a first angle in the slow axis direction and at a second angle in the fast axis direction, and at least a second reflective member including at least a first reflective element for deflecting the first output beam portion from the first direction to a second direction in the Z axis. The output beam is thus shaped to define at least two beams comprising at least the first portion and a remainder of the output beam which is propagated along the Z axis without deflection by any reflective member, with the first portion of the output beam being oriented approximately parallel to the un-deflected remainder.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: June 20, 2006
    Assignee: Fraunhofer USA, Inc.
    Inventors: Bodo Ehlers, Stefan Heinemann, Falk Doerfel
  • Patent number: 7012172
    Abstract: The present invention discloses methods for interfering with expression of the genes in plant cells by using replicating recombinant viral vectors. A host plant is infected at one or more locations with a recombinant viral vector. The vector is both an initiator and a target of the RNA-triggered gene silencing in plant cells. The vector upon infection is capable of directing self-replication and producing a transcription product of a nucleic acid segment. The transcription product interferes with the expression of a specific gene in plant cells.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: March 14, 2006
    Assignee: Fraunhofer, USA, Inc.
    Inventor: Vidadi Yusibov
  • Publication number: 20050095429
    Abstract: Wetted thin diamond films which are drapable are described. The films are mounted on various substrates and used as windows for electromagnetic radiation or form a surface coating on an article of manufacture.
    Type: Application
    Filed: October 31, 2003
    Publication date: May 5, 2005
    Applicants: Board of Trustees of Michigan State University, Fraunhofer USA, Inc.
    Inventors: Donnie Reinhard, Jes Asmussen, Michael Becker, Timothy Grotjohn, Thomas Schuelke, Roger Booth
  • Patent number: 6842175
    Abstract: The tools include components which are images produced by the system (103) that creates the virtual environment in response to inputs specifying the tool's location and the point of view of the tool's user. One class of the tools includes transparent components (121, 123); the image component of the tool is produced at a location in the virtual environment determined by the transparent component's location and the point of view of the tool's user. Tools in this class include a transparent pad (121) and a transparent stylus (123). The transparent pad (121) has an image component that may be used as a palette, as a magic lens, and as a device for selecting and transporting components of the virtual environment or even a portion of the virtual environment itself.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: January 11, 2005
    Assignee: Fraunhofer USA, Inc.
    Inventors: Dieter Schmalstieg, Oliver Bimber, L. Miguel Encarnacão
  • Patent number: 6698331
    Abstract: In a multi-layer armor system (10), useful for military vehicles, a metallic foam is provided as the shock energy-absorbing element. In a typical arrangement, the metallic foam shock-absorbing element (12) is sandwiched between a high strength strike plate (11) and a backing plate (13). Typically, the backing plate is a highly deforming metal, such as titanium, aluminum, or steel. However, the backing plate may comprise one or more layers of metal, ceramic or polymer-based composites. The high strength strike plate may be ceramic or metal. The shock-absorbing element is preferably a closed-cell metal foam with a high porosity that is effective in containing rearward deformation of the strike plate from a projectile strike. In a preferred embodiment, the shock-absorbing element is an aluminum foam with a porosity of 80 percent by volume.
    Type: Grant
    Filed: February 26, 2001
    Date of Patent: March 2, 2004
    Assignee: Fraunhofer USA, Inc.
    Inventors: Chin-Jye Yu, Terry Dennis Claar, Harald H. Eifert
  • Patent number: 6596961
    Abstract: A laser material processing head for monitoring and adjusting a laser welding process. The present invention provides a laser material processing head having a laser source for providing a laser beam for laser welding a workpiece. A position sensor coupled to the laser material processing head measures the difference between the actual position of the workpiece and a predetermined theoretical position of the workpiece. An adjustment mechanism allows for adjustment of the laser beam in response to the position sensor. A closed loop controller interfaces the position sensor with the adjustment mechanism thereby providing a closed loop system within the laser material processing head.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: July 22, 2003
    Assignee: Fraunhofer USA, Inc.
    Inventors: Bodo Ehlers, Stefan Heinemann