Abstract: The invention relates to a method and to a device for filling a medical packaging formed as a pouch. Preferably, the packaging is filled with liquid via a port, wherein the port is aerated with a protective gas, such as nitrogen, for example, during filling According to the invention, prior to filling with liquid, the packaging is filled with an inert gas, such as nitrogen, for example, which then provides the headspace of the filled and closed pouch. This results in a particularly low oxygen content in the headspace of the pouch.

Abstract: An on-body drug delivery device having a housing carried by a substrate. The device includes an adhesive module placed over at least a portion of said device to provide added securement of the device to the patient's body.

Abstract: A drug delivery device has a housing with an adhesive pad associated with the lower surface of the housing and configured to removably attach to a human body surface. A deformable drug reservoir is positioned within the housing and includes an outlet, with a needle fluidically connected to the drug reservoir and configured to define at least a portion of a fluid flow path between the drug reservoir and said human body surface. A delivery assembly is associated with the drug reservoir and includes a roller and a drive assembly, with the drive assembly being controlled by the controller during a drug delivery routine to move the roller from a first position to a second position so as to cause the roller to contact and deform the reservoir, thereby conveying a drug from the reservoir via the outlet.

Abstract: An on-body drug delivery device having a housing carried by a substrate. The substrate includes one or more cut-outs and/or one or more perforations to allow the substrate to better conform to the patient's body.

Abstract: The invention relates to a welding tool and to a method for pulse welding of plastic films for medical packs formed as bags. In general, the invention provides that the film material which is plastified during welding and thus free-flowing is specifically displaced into a deepened, edge-side inner region of the sealing surface by increasing the sealing surface area. The film material accumulated in the recess leads to an increase in the film thickness in the inner region (25i) of the weld seam (6, 7, 8). As a result, the mechanical stability of the medical pack formed as a bag can be improved.

Abstract: A connector assembly for connecting medical lines (3, 4) to each other comprises a first connector (1) having an insertion shaft (12), and a second connector (2) having an insertion opening (22). For connecting the first connector (1) and the second connector (2) to each other, the insertion shaft (12) of the first connector (1) is insertable along an insertion direction (I) into the insertion opening (22) of the second connector (2). For releasing the first connector (1) and the second connector (2) from each other, the insertion shaft (12) of the first connector (1) is removable from the insertion opening (22) of the second connector (2).

Abstract: An on-body injector includes a drug reservoir having an outlet. First and second pistons may be positioned within the reservoir, with the second piston first being moved to open the outlet, followed by the first piston being moved to convey a drug from the reservoir via the outlet. The reservoir may instead include a cover, with a valve positioned between the outlet and the cover. The valve is rotated to place a channel of the valve in fluid communication with a through-hole of the cover, allowing flow from the reservoir via the outlet. The reservoir may instead include a valve movable from a condition in which it deforms the outlet, preventing flow through the outlet, to a condition allowing flow. The reservoir may instead include a seal that is deformed by an increase in pressure within the reservoir, with the deformed seal being open to allow flow through the outlet.

Abstract: A wearable drug delivery device and related methods are described. The wearable drug delivery device can include: a housing; a flexible bag disposed within the housing; a cannula in fluid communication with the flexible bag; and a pumping mechanism for forcing a drug from the flexible bag and into the cannula, wherein the pumping mechanism is proximate the flexible bag and includes a spring-loaded paddle or a driving bag.

Abstract: The invention relates to a connector for a medical package containing a liquid. The connector comprises a lower section which has a connecting piece for a container of said medical package and a passageway which is closed by a septum, as well as an upper section which is provided with a cap that covers the septum and can be broken off, said septum having, on a top side, a plurality of connections in the form of elevations, for a spike and/or for a needle.

Abstract: A drug delivery assembly is used for delivering a medicament to a patient. The assembly includes a main body having a housing and defining a recess, with an actuator associated with the housing. An adhesive pad, configured to attach to a human body surface, is associated with a lower surface of the housing. The assembly also includes a cartridge configured to be at least partially inserted into the recess and having: a cartridge housing, a drug reservoir positioned within the cartridge housing, a stopper movably associated with the drug reservoir, and a needle movably associated with the drug reservoir. The actuator is manipulated to deploy the needle, with the actuator also engaging the cartridge to prevent removal of the cartridge from the recess during drug delivery. A rod of the body engages the stopper to move the stopper and dispense a medicament from the drug reservoir during drug delivery.

Abstract: The present invention relates to an assembly comprising an injection device comprising a container for a product, wherein the container includes a distal tip encompassing a channel providing a passageway for transferring the product, and an adaptor mounted onto the distal tip. The assembly further includes a heat-shrinkable film covering at least part of the container and at least part of the adaptor, wherein the heat-shrinkable film maintains the adaptor blocked in rotation and in translation relative to the container when the heat-shrinkable film is in heat-shrunk condition.

Abstract: A breaker device (1) for acting onto a closure element (40) of a medical tubing (4) comprises a drive arrangement (2) having an electric drive device (20) and a drive element (23) driven by the drive device (20), and a breaker module (3) which is arrangeable on the drive arrangement (2). The breaker module (3) comprises a housing (30), a movable part (31) movably arranged on the housing (30) and a breaking element (315) for acting onto the closure element (40) of the tubing (4), wherein the breaker module (3) in an attached state is placed on the drive arrangement (2), the drive element (23) being in operative connection with the movable part (31) in the attached state such that a movement of the drive element (23) causes the movable part (31) to move for actuating the breaking element (315). A control device (5) serves for controlling the electric drive device (20) for driving the drive element (23).

Abstract: A drug delivery device has a housing with an adhesive pad associated with the lower surface of the housing and configured to removably attach to a human body surface. A drug reservoir is positioned within the housing and includes an outlet with a valve, with a needle fluidically connected to the reservoir and configured to define at least a portion of a fluid flow path between the reservoir and the human body surface. A controller is configured to control the components of the drug delivery device to execute a drug delivery routine. The drug delivery device also includes pressurized fluid positioned to apply a force to the reservoir. The controller moves the valve from a closed condition to an open condition during a drug delivery routine to allow the pressurized fluid to deform the reservoir or move a plunger to convey the drug out of the reservoir via the outlet.

Abstract: A drug delivery device has a housing including upper and lower surfaces, with an adhesive pad associated with the lower surface of the housing and configured to removably attach to a human body surface. A drug reservoir is positioned within the housing, with a needle fluidically connected to the drug reservoir and configured to define at least a portion of a fluid flow path between the drug reservoir and said human body surface. A controller is configured to control the components of the drug delivery device to execute a drug delivery routine, with a display coupled to the controller and configured to receive signals from the controller so as to provide an indicium visible through the upper surface of the housing. The display may be electrical or mechanical in nature.

Abstract: An on-body injector includes a drug reservoir with an associated temperature sensor. A piston having an associated force sensor is driven to convey a drug out of the drug reservoir during a drug delivery routine. The temperature and force sensors are electrically coupled to a controller that controls the components of the on-body injector to execute a drug delivery routine. The controller receives signals from the temperature sensor indicative of a temperature of the drug within the reservoir and from the force sensor indicative of a force experienced by the piston during the drug delivery routine. The controller analyzes the signals to determine whether the measured force is different from an expected force at the measured temperature. The controller generates an error signal when the measured force is different from the expected force at the measured temperature.

Abstract: The present invention relates to the enhancement of the efficacy of anticancer agents by a composition comprising an aqueous phase, an oil phase, EPA and DHA for use in the treatment of solid tumors, wherein EPA and DHA are present in an amount of at least 65% based on the total weight of the oil phase wherein the composition comprises EPA and DHA in a weight ratio between 1:2 and 1:4, or wherein the composition comprises EPA and DHA in a weight ratio between 6:1 and 4:1 and wherein the treatment comprises administering the composition and administering at least one anticancer agent.

Abstract: A needleless injection port assembly includes first and second body parts and a resilient barrier received within the body. A cannula attached to the first body part is received within an internal cavity of the resilient barrier. The resilient barrier is moveable between a less axially compressed first position in which fluid flow through the injection port assembly is prevented and a more axially compressed second position in which fluid flow through the assembly is allowed. An interference fit is provided between the resilient barrier and the cannula to seal against fluid flow through the cannula when the resilient barrier is in the first position. The cannula has an internal fluid passageway with a non-circular cross section providing increased fluid flow.

Abstract: A syringe packaging system that includes a tube and a cap for enclosing a pre-filled syringe is disclosed. The tube includes a proximal end, a closed distal end, and a sidewall extending between the proximal and closed distal ends. The sidewall includes an injection molding gate. In one embodiment, a film is securable to a portion of the tube and a portion of the cap to connect the tube and the cap with the pre-filled syringe enclosed within the cap and the tube.

Abstract: A sealing cap for a container for holding a medical liquid comprising a cap body, which bounds an interior and has at least one opening, and at least one connection device, which is arranged on the cap body and to which a conveying device for feeding a medical liquid into the container or for removing a medical liquid from the container can be connected. The connection device has a sealing element, arranged on the cap body. The connection device has a break-off piece, which, in an initial state, is firmly connected to the cap body and covers the outer face of the sealing element in the outward direction. The break-off piece is connected to the cap body by means of a pre-determined breaking point. In addition, the sealing element is convex on the outer face.

Abstract: A method is described for opening a heat bonded sterile connection that includes a skin of material blocking flow between the connection site. The method includes applying external pressure to the connection site.