Abstract: A spray coating machine and process accommodates coating pans of various sizes and simplifies cleaning after particulate material in the pan is coated. A selected pan is supported on a trolley carried by a wheeled cart. After the cart is positioned adjacent the coating machine, the trolley and pan are extended into the machine, and then the pan lifted for support by a rotatable drive shaft and castors. The trolley is then removed from the machine, and the door is closed so that the coating process can commence. When coating is complete, the door is opened, and the trolley extended into the machine under the pan and raised for removal of the castors. Then, the trolley and pan are withdrawn from the machine. The trolley does not need cleaning after spraying, since the trolley is outside the machine during spraying of the coating solution.

Abstract: A spray coating machine and process accommodates coating pans of various sizes and simplifies cleaning after particulate material in the pan is coated. A selected pan is supported on a trolley carried by a wheeled cart. After the cart is positioned adjacent the coating machine, the trolley and pan are extended into the machine, and then the pan lifted for support by a rotatable drive shaft and castors. The trolley is then removed from the machine, and the door is closed so that the coating process can commence. When coating is complete, the door is opened, and the trolley extended into the machine under the pan and raised for removal of the castors. Then, the trolley and pan are withdrawn from the machine. The trolley does not need cleaning after spraying, since the trolley is outside the machine during spraying of the coating solution.

Abstract: A steam or reactant system is provided for a roller compactor to provide improved compaction or functional characteristic of powdered materials, such as active pharmaceutical ingredients. The steam or reactants can be added through conduits terminating in nozzles adjacent the nip zone of the compaction rollers. The injection nozzles can be directed tangentially from the above the rollers or laterally from the sides of the rollers. In one embodiment, the moisture is in the form of steam. The resulting compacting sheet has improved compaction characteristics and reduced compression variability.

Abstract: A Wurster processor and a powder feed system are coupled via an eductor so as to supply dry powder through the air diverter sleeve of the Wurster for discharging onto the circulating particles during operation of the Wurster. Agglomeration and aggregation of the particles is eliminated or minimized by isolating or separating the liquid spray by the spray gun from the dry powder.

Abstract: An overpressure absorption mechanism is provided for a fluid bed processor. The mechanism includes spring assemblies mounted in the legs of the processor. The arms of the lower housing section extend into the legs and are supported on the springs. If an overpressure condition arises within the processor, the springs compress to allow movement between the housing sections to allow engagement of clamping rings which contain the over pressure condition.

Abstract: The fluidized bed processor of the present invention includes an internal filter assembly with a rack and a cartridge-type filter supported at the lower end by a bracket. The rack includes an elongated rod extending through the filter. An end cap is provided on the lower end of the rod for normal sealing engagement with the filter bracket. During normal operation of the processor, the upper and lower ends of the filter are sealed. During or after cleaning of the filter, the rack is lowered, and a spring separates the filter and support bracket from the end cap so as to create a gap for drainage of cleaning fluid.

Abstract: The fluidized bed processor of the present invention includes an internal filter assembly with a rack and a cartridge-type filter supported at the lower end by a bracket. The rack includes an elongated rod extending through the filter. An end cap is provided on the lower end of the rod for normal sealing engagement with the filter bracket. During normal operation of the processor, the upper and lower ends of the filter are sealed. During or after cleaning of the filter, the rack is lowered, and a spring separates the filter and support bracket from the end cap so as to create a gap for drainage of cleaning fluid.