Abstract: The present invention relates to thiophene derivatives represented by the following formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof, which has TNF-? production suppressive activity and hematologic cancer cell proliferation inhibitory activity, and is useful for the treatment of rheumatoid arthritis, Crohn's disease, ulcerative colitis, and further, hematologic cancer.

Abstract: The present invention relates to thiophene derivatives represented by the following formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof, which has TNF-? production suppressive activity and hematologic cancer cell proliferation inhibitory activity, and is useful for the treatment of rheumatoid arthritis, Crohn's disease, ulcerative colitis, and further, hematologic cancer.

Abstract: A first constituent member configured such that a plurality of panels overlaps and a second constituent member configured such that a plurality of panels overlaps are included, in which a first link member that can be expanded and contracted is connected to the first constituent member, a second link member that can be expanded and contracted is connected to the second constituent member, each of the constituent members can be expanded and contracted by expansion and contraction of each of the link members, the first constituent member and the second constituent member can relatively be rotated around rotation axes and also can removably be connected, the first link member and the second link member are connected to both ends of connecting link arm members via a free joint respectively, and the first link member and the second link member can be separated from each other.

Abstract: A first constituent member constructed such that at least portions of a plurality of panels overlap and a second constituent member constructed such that at least portions of a plurality of panels overlap are included, in which the first constituent member and the second constituent member are connected to a link member that can be expanded and contracted, the first constituent member and the second constituent member are expanded and contracted by expansion and contraction of the link member, and the first constituent member and the second constituent member can relatively be rotated around rotation axes.

Abstract: The invention relates to the field of prevention and treatment of cancer, in particular suppression of tumor manifestation. The invention also relates to compounds for use in this field. A novel tumor manifestation suppression (TMS) regulation in a mammalian brain is recognized. The invention relates to compounds, pharmaceutical preparations, in particular medicaments for use in the prevention and treatment of cancer, in particular suppression of tumor manifestation based on said TMS regulation as well as methods for the same.

Abstract: The invention relates to the field of prevention and treatment of cancer, in particular suppression of tumor manifestation. The invention also relates to compounds for use in this field. A novel tumor manifestation suppression (TMS) regulation in a mammalian brain is recognized. The invention relates to compounds, pharmaceutical preparations, in particular medicaments for use in the prevention and treatment of cancer, in particular suppression of tumor manifestation based on said TMS regulation as well as methods for the same.

Abstract: It is already known that 1-(benzofuran-2-yl)-2-propylaminopentane or a pharmacologically acceptable acid addition salt thereof exhibits an excellent effect as an antidepressant, a psychotropic drug, an antiparkinsonian drug, and an anti-Alzheimer's disease drug. However, it has not been known at all that the compound is effective for the prevention or therapy of attention-deficit/hyperactivity disorder (ADHD). The present invention has newly found that 1-(benzofuran-2-yl)-2-propylaminopentane or a pharmacologically acceptable acid addition salt thereof is effective for the prevention or therapy of ADHD, and has been accomplished.

Abstract: It is already known that 1-(benzofuran-2-yl)-2-propylaminopentane or a pharmacologically acceptable acid addition salt thereof exhibits an excellent effect as an antidepressant, a psychotropic drug, an antiparkinsonian drug, and an anti-Alzheimer's disease drug. However, it has not been known at all that the compound is effective for the prevention or therapy of attention-deficit/hyperactivity disorder (ADHD). The present invention has newly found that 1-(benzofuran-2-yl)-2-propylaminopentane or a pharmacologically acceptable acid addition salt thereof is effective for the prevention or therapy of ADHD, and has been accomplished.

Abstract: Sustained release micropellets showing a stable controlled-release of a drug without being affected by the changes in pH value etc., characterized by being produced by coating core particles with a layer containing a water-soluble drug and further forming a film layer containing a water-insoluble polymer compound and a plasticizer on the thus obtained particles, locating a water-soluble filler layer between the water soluble drug-containing layer and the film layer, and having an average particle size of 300 ?m or less; medicinal compositions containing these micropellets; and a process for producing the same.

Abstract: The present invention provides a therapeutic agent for substance dependence, which prevents relapse/recurrence of compulsive substance-taking behavior based on craving for addictive substances such as stimulant substances, opioids, barbiturate type anesthetics, hallucinogens, cocaine, hemp, cannabis, alcohol, or volatile organic solvents. (?)-1-(Benzofuran-2-yl)-2-propylaminopentane or a pharmacologically acceptable acid addition salt thereof is useful as a therapeutic agent for substance dependence, which prevents relapse/recurrence of compulsive substance-taking behavior associated with craving for addictive substances.

Abstract: There are provided a process for preparing an optically active aminopentane derivative that is promising as a psychotropic agent, an antidepressant agent, an antiparkinsonian agent, an anti-Alzheimer's agent, an apoptosis inhibitor, or the like; a novel optically active intermediate oxathiazolidine derivative very useful in the production of the aminopentane derivative; and process for the production thereof. The optically active aminopentane derivatives can be produced in an industrially advantageous manner from a novel optically active oxathiazolidine derivative represented by formula (5): wherein * indicates the position of an asymmetric carbon atom in the R or S configuration, and n is 0 or 1.

Abstract: The present invention provides an adhesive preparation, which includes a backing and a pressure-sensitive adhesive layer formed on at least one side of the backing, the pressure-sensitive adhesive layer containing (?)-(R)—N,?-dimethyl-N-2-propynylphenethylamine and/or a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive, an antioxidant and a metal hydroxide.

Abstract: The present invention provides an adhesive preparation, which includes a backing and a pressure-sensitive adhesive layer formed on at least one side of the backing, the pressure-sensitive adhesive layer containing (?)-(R)—N,?-dimethyl-N-2-propynylphenethylamine and/or a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive and a component which is liquid at 25° C. and has two or more ester bonds in one molecule thereof.

Abstract: The present invention provides an adhesive preparation, which includes a backing and a pressure-sensitive adhesive layer formed on at least one side of the backing, the pressure-sensitive adhesive layer containing (?)-(R)—N,?-dimethyl-N-2-propynylphenethylamine and/or a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive and one or two or more stabilizers selected from the group consisting of 2-mercaptobenzimidazole, sodium sulfite, butylhydroxyanisole and butylhydroxytoluene.

Abstract: The present invention provides a therapeutic agent for substance dependence, which prevents relapse/recurrence of compulsive substance-taking behavior based on craving for addictive substances such as stimulant substances, opioids, barbiturate type anesthetics, hallucinogens, cocaine, hemp, cannabis, alcohol, or volatile organic solvents. (?)-1-(Benzofuran-2-yl)-2-propylaminopentane or a pharmacologically acceptable acid addition salt thereof is useful as a therapeutic agent for substance dependence, which prevents relapse/recurrence of compulsive substance-taking behavior associated with craving for addictive substances.

Abstract: There are provided a process for preparing an optically active aminopentane derivative that is promising as a psychotropic agent, an antidepressant agent, an antiparkinsonian agent, an anti-Alzheimer's agent, an apoptosis inhibitor, or the like; a novel optically active intermediate oxathiazolidine derivative very useful in the production of the aminopentane derivative; and process for the production thereof. The optically active aminopentane derivatives can be produced in an industrially advantageous manner from a novel optically active oxathiazolidine derivative represented by formula (5): wherein * indicates the position of an asymmetric carbon atom in the R or S configuration, and n is 0 or 1.

Abstract: Disclosed is a magnetic therapeutic device for use as a wearable article including a necklace to exert a blood flow-promoting effect on a body of a user. The magnetic therapeutic device comprises an elongated flexible magnet portion formed from a mixture of a silicone rubber and a magnetic powder to extend in a given direction, and magnetically polarized, and a flexible sheath portion formed from a silicone rubber to cover over an entire outer periphery of the magnet portion. The magnetic therapeutic device of the present invention can more uniformly apply a magnetic flux to a body of a user.

Abstract: Disclosed is a cloth and solid piece assembly, which comprises a cloth which is subjected to an embossing process to have a receiving portion formed through the embossing process in such a manner as to protrude from a surface of the cloth in a direction perpendicular to the surface to have an opening oriented in a direction opposite to the protruding direction, a solid piece received inside the receiving portion, and an adhesive material. The adhesive material is received inside the receiving portion and bonded to an inner peripheral surface of the receiving portion while plugging the opening of the receiving portion, so as to fix the solid piece inside the receiving portion. The cloth and solid piece assembly can reliably suppress peeling of a bonded region between the adhesive material and the cloth, in a simple structure.