Abstract: Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with a taxane, such as, paclitaxel and derivatives thereof, which are water insoluble or poorly water soluble. The aggregates are formed by interaction of a taxane and a homopolymer. Such aggregates improve drug solubility, stability, delivery and efficacy.
Type:
Grant
Filed:
February 25, 2021
Date of Patent:
October 31, 2023
Assignees:
ANP Technologies, Inc., Fulgent Therapeutics, Inc.
Inventors:
Ray Yin, Jing Pan, Yubei Zhang, Bingsen Zhou, Yun Yen