Patents Assigned to G. D. Searle & Co.
  • Use of amino-isoxazolidone compounds for improvement of implicit memory
    Publication number: 20040214873
    Abstract: A class of amino-isoxazolidone compounds is described for use to improve implicit memory in patients susceptible to or afflicted with Alzheimer's Disease. Preferred compounds of this class are D-cycloserine and its prodrugs.
    Type: Application
    Filed: May 19, 2004
    Publication date: October 28, 2004
    Applicant: G. D. Searle & Co.
    Inventors: Robert L. Herting, Barbara L. Schwartz, Stephen I. Deutsch
  • Nucleic acids encoding human tissue factor inhibitor
    Patent number: 6806360
    Abstract: A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined.
    Type: Grant
    Filed: March 4, 2003
    Date of Patent: October 19, 2004
    Assignee: G.D. Searle & Co.
    Inventors: Tze Chein Wun, Kuniko K. Kretzmer, George J. Broze, Jr.
  • Substituted benzopyran derivatives for the treatment
    Patent number: 6806288
    Abstract: A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: October 19, 2004
    Assignee: G.D. Searle & Co.
    Inventors: Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J Rogier, Jr., Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartman, Cindy L Ludwig, Suzanne Metz, Donald E Korte
  • Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis
    Publication number: 20040204367
    Abstract: Non-peptidic compounds characterized by containing a segment condensed from pipecolic acid, aspartic acid, proline and threonine, or derivatives thereof, are useful to treat autoimmune diseases and inflammatory conditions.
    Type: Application
    Filed: July 2, 2003
    Publication date: October 14, 2004
    Applicant: G.D. Searle & Co.
    Inventor: Gunnar J. Hanson
  • Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
    Publication number: 20040198989
    Abstract: Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Application
    Filed: November 19, 2003
    Publication date: October 7, 2004
    Applicant: G.D. Searle & Co.
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Michael L. Vazquez, James A. Sikorski, Balekudru Devadas, Srinivasan Nagarajan, David L. Brown, Joseph J. McDonald
  • Micronized eplerenone compositions
    Publication number: 20040192661
    Abstract: The invention relates to oral pharmaceutical compositions useful as aldosterone receptor blockers comprising the active agent micronized eplerenone in an amount of about 10 mg to about 1000 mg and one or more carrier materials.
    Type: Application
    Filed: April 2, 2004
    Publication date: September 30, 2004
    Applicant: G. D. Searle & Co.
    Inventors: Shilpa S. Thosar, Rajeev D. Gokhale, Dwain S. Tolbert
  • Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension
    Publication number: 20040192780
    Abstract: Compounds characterized generally as alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol derivatives are useful as renin inhibitors for the treatment of hypertension.
    Type: Application
    Filed: April 12, 2004
    Publication date: September 30, 2004
    Applicant: G.D. Searle & Co.
    Inventor: Gunnar J. Hanson
  • Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
    Publication number: 20040192930
    Abstract: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders.
    Type: Application
    Filed: November 3, 2003
    Publication date: September 30, 2004
    Applicant: G.D. Searle & Co.
    Inventors: John J. Talley, Thomas D. Penning, Paul W. Collins, Donald J. Rogier, James W. Malecha, Julie M. Miyashiro, Stephen R. Bertenshaw, Ish K. Khanna, Matthew J. Graneto, Roland S. Rogers, Jeffery S. Carter, Stephen H. Docter, Stella S. Yu
  • Alpha-and beta-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
    Publication number: 20040171653
    Abstract: &agr;- and &bgr;-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: October 21, 2003
    Publication date: September 2, 2004
    Applicant: G.D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, Eric T. Sun
  • Combination therapy of angiotensin converting enzyme inhibitor and aldosterone antagonist for reducing morbidity and mortality from cardiovascular disease
    Publication number: 20040167108
    Abstract: Combinations of an ACE inhibitor, an aldosterone antagonist, and a loop diuretic are described for use in treatment of circulatory disorders. Of particular interest are therapies using captopril, enalapril or lisinopril co-administered with spironolactone. This co-therapy would be particularly useful to reduce the death rate or the number of non-fatal hospitalizations or prevent the progression of congestive heart failure in patients with cardiovascular disease.
    Type: Application
    Filed: January 8, 2004
    Publication date: August 26, 2004
    Applicant: G.D. Searle & Co.
    Inventors: Alfonzo T. Perez, Debra J. Asner, Richard J. LaChapelle, John C. Alexander, Barbara Roniker
  • Substituted biphenyl compounds for the treatment of inflammation
    Publication number: 20040158074
    Abstract: A class of substituted biphenyl compounds is described for use in treating inflammation and inflammation-related disorders.
    Type: Application
    Filed: January 13, 2004
    Publication date: August 12, 2004
    Applicant: G.D. Searle & Co.
    Inventors: David B. Reitz, James J. Li, Monica B. Norton
  • Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
    Publication number: 20040157915
    Abstract: Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and HMG Co-A reductase inhibitors for the treatment of hyperlipidemic conditions.
    Type: Application
    Filed: July 17, 2003
    Publication date: August 12, 2004
    Applicant: G.D. Searle & Co.
    Inventors: Bradley T. Keller, Kevin C. Glenn, Robert E. Manning
  • Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
    Publication number: 20040147758
    Abstract: Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
    Type: Application
    Filed: October 3, 2003
    Publication date: July 29, 2004
    Applicant: G.D. Searle & Co.
    Inventors: Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Michael L. Vazquez, James A. Sikorski, Balekudru Devadas, Srinivasan Raj Nagarajan, Joseph J. McDonald
  • Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
    Publication number: 20040147565
    Abstract: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
    Type: Application
    Filed: January 12, 2004
    Publication date: July 29, 2004
    Applicant: G.D. Searle & Co.
    Inventors: John J. Talley, James A. Sikorski, Balekudru Devadas, Matthew J. Graneto, Jeffery S. Carter, Bryan H. Norman, Roland S. Rogers, Kathy L. Rogers, Hwang-Fun Lu, David L. Brown
  • Site specific ligation of proteins to synthetic particles
    Publication number: 20040131584
    Abstract: The present invention relates to site-specific conjugation of synthetic particles to proteins.
    Type: Application
    Filed: November 25, 2003
    Publication date: July 8, 2004
    Applicant: G. D. Searle & Co.
    Inventors: Stephen C. Lee, Ranjani V. Parthasarathy
  • Heterocyclic glycyl beta-alanine derivatives
    Publication number: 20040127477
    Abstract: The present invention relates to a class of compounds represented by the Formula I 1
    Type: Application
    Filed: November 20, 2003
    Publication date: July 1, 2004
    Applicant: G. D. Searle & Co.
    Inventors: Nizal Samuel Chandrakumar, Bipinchandra Nanubhai Desai, Balekudru Devadas, Alan Frank Gasiecki, Renee Huff, Ish K. Khanna, James W. Malecha, Julie M. Miyashiro, Shashidhar N. Rao, Joseph Gerace Rico, Thomas Edward Rogers, Peter Gerrard Ruminski, Mark Andrew Russell, Yi Yu
  • Renal-selective biphenylalkyl 1H-substituted-1,2,4-triazole angiotensin II antagonists for treatment of hypertension
    Publication number: 20040121989
    Abstract: Renal-selective compounds are described which, in one embodiment, are prodrugs preferentially converted in the kidney to compounds capable of blocking angiotensin II (AII) receptors. These prodrugs are conjugates formed from two components, namely, a first component provided by an AII antagonist compound and a second component which is capable of being cleaved from the first component when both components are chemically linked within the conjugate. The two components are chemically linked by a bond which is cleaved selectively in the kidney, for example, by an enzyme. The liberated AII antagonist compound is then available to block AII receptors within the kidney.
    Type: Application
    Filed: December 19, 2002
    Publication date: June 24, 2004
    Applicant: G.D. Searle & Co.
    Inventors: David B. Reitz, Robert E. Manning
  • Glucamine salts for treating hepatitis virus infections
    Patent number: 6747149
    Abstract: N-Substituted glucamine compounds of formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections the compounds of formular I may be used alone, or in combinatioin with another antiviral agent selected from among nucleosides, nucleotides, immunomodulators, immunostimulants or various combination of such other agents.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: June 8, 2004
    Assignee: G. D. Searle & Co.
    Inventors: Richard A. Mueller, Martin L. Bryant, Richard A. Partis
  • Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 6743929
    Abstract: Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: June 1, 2004
    Assignee: G. D. Searle & Co.
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
  • Methods for the treatment or prophylaxis of aldosterone-mediated pathogenic effects in a subject using an epoxy-steroidal aldosterone antagonist
    Publication number: 20040102424
    Abstract: The present invention provides methods for the treatment or prophylaxis of one or more aldosterone-mediated pathogenic effects in a subject suffering from or susceptible to the pathogenic effect or effects wherein the subject has one or more conditions selected from the group consisting of a sub-normal endogenous aldosterone level, salt sensitivity and an elevated dietary sodium intake. The methods comprise administering to the subject a therapeutically-effective amount of one or more epoxy-steroidal compounds that are aldosterone antagonists.
    Type: Application
    Filed: October 9, 2003
    Publication date: May 27, 2004
    Applicant: G.D. Searle & Co.
    Inventors: Gordon H. Williams, John W. Funder, Susan M. Garthwaite, Barbara Roniker, Kenton N. Fedde, Ricardo Rocha