Abstract: An oral supplement composition and method of making and using it, in which a combination of fourteen different specialized mushroom species, each of which has its own unique immunomodulatory properties, demonstrate enhancement of the immune system. When taken together, the combination of mushroom species exert a potentiated, synergistic effect that enhances immune function greater than the sum of each mushroom species' immunoenhancing influence. The oral supplement can be prepared into a variety of dosage forms, such as capsules, caplets, tablets, pills, dispersions, suspensions, solution, powders, teas, or syrup concentrates, and can be packaged in bottles or other packaging for sale.