Patents Assigned to GE Healthcare Bio-Sciences AB
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Patent number: 10451591Abstract: The invention relates to valve system for controlling a process fluid within a liquid processing system. The valve system comprises a valve arrangement, a pneumatic or hydraulic control system, and a connector unit. When the valve arrangement is connected to the connector unit, two or more valves are formed, such that the pneumatic or hydraulic control system controls an open/close or pressure control mode of the valves. A pump diaphragm system is disclosed, as well as a system for purifying a biological material that comprises the valve system or the pump diaphragm system. Also discloses are methods of using the valve system or the pump diaphragm system in a process for the purification of a biological material.Type: GrantFiled: June 21, 2016Date of Patent: October 22, 2019Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Klaus Gebauer, Stefan Sjolander, Andreas Torbjorn Lundin
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Patent number: 10449350Abstract: Provided is a connector for substantially aseptic connection of tubing, that includes a central tubular stem member with a line connection end and a coupling end having an annular gasket arranged to engage a similar annular gasket on a similar second connector in sealing abutment and a tubular socket member, concentrically arranged outside the stem member, having a flange concentrically arranged outside the coupling end and a cover film releasably bonded to the flange and covering the coupling end of the stem member, the annular gasket and at least a portion of the flange. The socket member is rotatable around the stem member and the connector also has an annular seal member in sealing abutment between an inside of the socket member and an outside of the stem member.Type: GrantFiled: November 5, 2014Date of Patent: October 22, 2019Assignee: GE HEALTHCARE BIO-SCIENCES ABInventor: Klaus Gebauer
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Patent number: 10450540Abstract: The invention discloses a flexible bag assembly for cultivation of cells, comprising one or more bags forming a plurality of cultivation compartments, wherein a drain port in at least a first cultivation compartment is adapted to be fluidically connected with a second cultivation compartment upon opening of a valve means. It also discloses a bioreactor with the bag assembly mounted on a rocking tray and a method of cultivating cells in the assembly.Type: GrantFiled: April 27, 2015Date of Patent: October 22, 2019Assignee: GE Healthcare Bio-Sciences ABInventors: Klaus Gebauer, Andreas Castan, Camilla Estmer-Nilsson, Thomas Falkman, Anders Wilen, Michael Miller, Ralph Stankowski
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Patent number: 10444230Abstract: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface.Type: GrantFiled: April 13, 2016Date of Patent: October 15, 2019Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Robert Karlsson, Karl Andersson, Christina Wass
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Patent number: 10429359Abstract: Automated two step chromatography purification system comprising a, system controller, a capture flow path comprising at least one pump, an elution flow path comprising at least one pump, and a valve arrangement for selective connection of two capture columns to the capture flow path and the elution flow path respectively such that both flow paths may be operated simultaneously and in parallel.Type: GrantFiled: February 13, 2015Date of Patent: October 1, 2019Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Christer Olof Eriksson, Nils Norrman
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Patent number: 10421074Abstract: The present invention provides a microplate comprised of multiwell strips connected in such a way as to permit the microplate to unfold and to pass in a linear fashion past a fraction collector and then re-fold back into a microplate configuration. Furthermore, the invention provides for the use of the microplates of the invention in a variety of different laboratory methods.Type: GrantFiled: November 25, 2014Date of Patent: September 24, 2019Assignee: GE Healthcare Bio-Sciences ABInventors: Nils Norrman, Henrik Ostlin
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Patent number: 10413875Abstract: An arrangement for adding a first fluid component into a flow system, said arrangement comprising: a first pump provided in a first component adding fluid line which is connecting a first system fluid line of the flow system with a first fluid component source comprising the first fluid component to be added into the flow system; and a second pump provided in a second component adding fluid line connected in parallel with the first component adding fluid line, said second component adding fluid line connecting the first system fluid line of the flow system with a first fluid component source comprising the first fluid component to be added into the flow system.Type: GrantFiled: February 7, 2017Date of Patent: September 17, 2019Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Jan-Erik Pettersson Lynga, Asa Dahlstedt Hagman
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Patent number: 10391422Abstract: A chromatography column having a longitudinal axis and comprising a column wall with a first end and a second end, a first end plate assembly removably connectable to said first end of the column wall, a second end plate assembly removably connectable to said second end of the column wall, wherein said first end plate assembly, said column wall and said second end plate assembly are arranged along the longitudinal axis of the column wherein the column wall, and/or first end plate assembly and/or second end plate assembly is/are rotatable about an axis of rotation wherein said axis of rotation is parallel to the longitudinal axis of said column and positioned outside the column.Type: GrantFiled: April 4, 2016Date of Patent: August 27, 2019Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Per Lofving, Mats Olsson, Sven Wounder, Jerker Persson
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Patent number: 10393709Abstract: A holding system for holding and hoisting a chromatography column of one or more chromatography columns is disclosed. The holding system includes an upright member and a plurality of holding members movably arranged along the upright member. A first supporting member is positioned at an end portion of the chromatography column, wherein a holding member of the plurality of holding members is configured to be engaged to the first supporting member. A second supporting member is positioned at another end portion of the chromatography column. A holding member of the plurality of holding members is configured to be engaged to the second supporting member. One or more hoist assisting members may be also present. A hoist assisting member is operatively connected to the holding member engaged to the first supporting member. The hoist assisting member is operable to move the holding member connected to the first supporting member for hoisting the chromatography column.Type: GrantFiled: March 30, 2015Date of Patent: August 27, 2019Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Manoj Ramakrishna, Kishore Chengalvarayan, Nikhil Kamble
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Publication number: 20190256812Abstract: A method for controlling at least one culture parameter in a bioreactor bag (1; 31a, 31b) provided in a bioreactor system, said method comprising the steps of: providing bioreactor information to a control unit (5; 35) controlling the bioreactor system; controlling the at least one culture parameter in dependence of the bioreactor information.Type: ApplicationFiled: April 30, 2019Publication date: August 22, 2019Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Klaus Gebauer, Eva Lindskog, Lars Magnusson
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Patent number: 10376813Abstract: The present invention relates to a method for the determination of chromatography conditions for the separation of a biomolecule from a liquid sample, which method comprises selecting a number of experiments using design of experiments (DoE); performing said experiments with in-line conditioning of orthogonal quality measures; and based on the results from the experiments, determining efficient chromatography conditions for said biomolecule. The invention also relates to a system for performing the method as well as a computer program and an instrument comprising such a computer program.Type: GrantFiled: June 3, 2016Date of Patent: August 13, 2019Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Enrique Napoleon Carredano, Gustav Jose Rodrigo
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Patent number: 10371608Abstract: The invention discloses a cellulose or glass fiber paper for preservation of biological samples, which comprises 4-30 wt % of a hydrophilic branched carbohydrate polymer. It also discloses a method for preservation of biological samples by applying and drying them on the paper.Type: GrantFiled: October 29, 2012Date of Patent: August 6, 2019Assignee: GE Healthcare Bio-Sciences ABInventors: Mattias Algotsson, Miles W. Burrows, Jimmy Hedin Dahlstrom, Ylva Laurin, Ronnie Palmgren, Jinyu Zou
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Patent number: 10343083Abstract: Method for controlling a liquid chromatography system comprising a system pump and a column in fluid communication with the system pump by a fluid flow path, the method comprising the steps: registering the system pressure at a flow path position close to the system pump, controlling the operation of the system pump in response to the registered system pressure, estimating a pre-column pressure based on the registered system pressure, the characteristics of the flow path, and the viscosity and flow-rate of the liquid in the system, and controlling the operation of the system pump in response to the estimated pre-column pressure.Type: GrantFiled: August 22, 2013Date of Patent: July 9, 2019Assignee: GE Healthcare Bio-Sciences ABInventor: Olle Bjernulf
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Publication number: 20190194589Abstract: The invention discloses a hollow profile wall segment (1) for a bioreactor or mixer support vessel (2;2a;2b), comprising a base profile (3) with two parallel wide sides (4,5), two narrow sides (6,7) and at least one heat exchange channel (8) extending in a longitudinal direction of the base profile through an interior space (9) in the base profile, wherein the hollow profile wall segment is adapted to be joined with similar hollow profile wall segments to form a side wall (12) of a bioreactor or mixer support vessel (2) and wherein each narrow side comprises at least one coupling member (10,11;11a;150) capable of securing the hollow profile wall segment side by side with similar hollow profile wall segments.Type: ApplicationFiled: May 11, 2017Publication date: June 27, 2019Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: KLAUS GEBAUER, THOMAS ERIK ARCTAEDIUS, PATRICK JONSSON, ANDREAS MARCSTROM
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Patent number: 10315134Abstract: The invention relates to a chromatography column assembly that offers an affordable self-packed column for performing chromatographic separation. The chromatography column assembly comprises a column tube having a first and a second opening at substantially opposite ends, and an end cap of either a snap fit design or a bolted design. The column assembly may further include an adaptor shaft inserted into the column through the end cap for achieving a desired bed volume. The column assembly may also include a second end cap enclosing the second opening, and an optional adaptor shaft may be inserted into the column through the second end cap, enabling further adjustment of the bed volume.Type: GrantFiled: August 15, 2014Date of Patent: June 11, 2019Assignee: GE Healthcare Bio-Science ABInventors: Veena Rao, Manoj Ramakrishna, Nikhil Kamble
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Patent number: 10307692Abstract: A chromatography column including: a tubular housing; a first end unit removably connected to a first end of the tubular housing; a second end unit removably connected to a second end of the tubular housing; an adaptor assembly movable within said tubular housing; an adaptor rod connected to said adaptor assembly, which adaptor rod is arranged to extend through an opening in the first end unit; a filter removably connected to the adaptor assembly; and a frame connected to said tubular housing for supporting the column on a floor. At least an actuating means is arranged on the frame, so that the column can be lifted and lowered in a substantially vertical direction.Type: GrantFiled: June 18, 2013Date of Patent: June 4, 2019Assignee: GE Healthcare Bio-Sciences ABInventors: Stefan Kjell Eriksson, Andreas Bergstrom
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Patent number: 10309938Abstract: A rotary valve comprising a stator and a rotor wherein the stator comprises at least three inlet primary connection ports, at least three outlet primary connection ports, at least three inlet secondary connection ports and at least three outlet secondary connection ports, and wherein rotor interconnection paths are arranged to in the different rotor positions interconnect the inlet primary connection ports with the inlet secondary connection ports and the outlet primary connection ports with the outlet secondary connection ports such that all of at least three inlet secondary connection ports can be connected one at the time to each of at least three inlet primary connection port and all of at least three outlet secondary connection ports can be connected one at the time to each of at least three outlet primary connection port by rotating the rotor into the different rotor positions.Type: GrantFiled: December 15, 2014Date of Patent: June 4, 2019Assignee: GE HEALTHCARE BIO-SCIENCES ABInventor: Bjorn Olovsson
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Patent number: 10302603Abstract: A rotary valve comprising a stator and a rotor, wherein the stator comprises at least three primary connection ports and at least three secondary connection ports, and wherein rotor interconnection paths are arranged to in the different rotor positions interconnect the primary connection ports with the secondary connection ports such that all of at least three secondary connection ports can be connected one at the time to each of at least three primary connection port by rotating the rotor into the different rotor positions. A chromatography system comprising at least three chromatography columns and a column inlet rotary valve, a column outlet rotary valve and a feed recirculation flow path.Type: GrantFiled: December 15, 2014Date of Patent: May 28, 2019Assignee: GE Healthcare Bio-Science ABInventors: Bjorn Olovsson, Thomas Arctaedius
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Publication number: 20190154641Abstract: The present invention relates to a method for providing information from a fraction collector in a liquid chromatography system, the system comprising a column, at least one reservoir for containing a fluid, at least one pump connected to said reservoir, a column arranged to receive an input from the reservoir, a measuring device for performing measurements on a fluid output from the column, and a fraction collector for receiving said fluid output in a plurality of receiving vessels, wherein the method comprises—determining at least one parameter of the fraction collector, and—providing information of said parameter on a display in the form of a graphical representation.Type: ApplicationFiled: April 6, 2017Publication date: May 23, 2019Applicant: GE Healthcare Bio-Sciences ABInventors: Petra BANGTSSON, Lena NYHOLM, Bengt GORANSSON
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Publication number: 20190128859Abstract: A chromatography lab system comprising a cooling compartment arranged to hold both fraction collector devices and sample containers, whereby the cooling compartment comprises an identifying device which is arranged to identify the fraction collector devices such that fractions from the chromatography are collected only in the fraction collector devices.Type: ApplicationFiled: October 30, 2018Publication date: May 2, 2019Applicant: GE Healthcare Bio-Sciences ABInventors: Bjorn Olovsson, Karol Lacki, Mikael Berg