Patents Assigned to GE Healthcare Bio-Sciences Corp.
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Patent number: 10481375Abstract: Disclosed is an optical arrangement providing selective plane illumination, including an inverted illumination objective mounted below a sample support in use providing a line or plane of light at the sample support, and at least one image collection objective mounted above the support, said inverted illumination objective having an illumination objective optic axis, and said image collection objective having an image collection objective optical axis, wherein illumination light is arranged to propagate toward the illumination objective lateral offset to the illumination objective optical axis such that the illumination light leaving the illumination objective propagates toward the sample support at an oblique angle relative to the illumination objective optical axis, and wherein the image objective optical axis has an angle ? which is obtuse to the illumination objective optical axis and generally perpendicular to light propagating at the sample support.Type: GrantFiled: December 8, 2015Date of Patent: November 19, 2019Assignee: GE Healthcare Bio-Sciences Corp.Inventor: Jeremy R. Cooper
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Patent number: 10463988Abstract: Methods and systems for chromatography are disclosed that employ a flexible container configured to fit within a support structure and adapted to receive a filtration or absorptive medium, such as a chromatography resin. The flexible container can include at least one inlet, at least one outlet, and a separation barrier peripherally sealed within the container to separate the container into a resin containing portion and a drainage portion. The barrier can be configured to exclude the resin material from the drainage portion during use while allowing fluids to pass therethrough. The disposable chromatography system can further include one or more agitators disposed within the flexible container and adjustably configured to be raised or lowered in the flexible container. When the agitator is in the raised position, the resin packing material can operate in a settled, packed-bed configuration.Type: GrantFiled: September 23, 2011Date of Patent: November 5, 2019Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: John J. Vicalvi, Joseph Makowiecki, Joseph D. Crowell, Parrish M. Galliher
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Patent number: 10442674Abstract: Disclosed herein are embodiments of a valve assembly for preventing dead leg spaces in a container or tubing, the embodiments including a three-way valve system for controlling back-pressure in a fluid generating device, such as a single-use high pressure bioreactor. Also disclosed is a pressurized reactor system for bioprocessing, comprising a single-use container including a flexible wall or a semi-rigid wall.Type: GrantFiled: July 29, 2016Date of Patent: October 15, 2019Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Colin R. Tuohey, Thomas Erdenberger, Richard L. Damren, Kenneth Clapp, Parrish M. Galliher, Jonathan Kenney
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Publication number: 20190302720Abstract: The present disclosure relates to a manufacturing system, method and control circuitry for quality assured manufacturing of at least two biopharmaceutical products. The manufacturing system comprises a warehouse facility, a hydration facility, and at least two biopharmaceutical manufacturing facilities, wherein the warehouse facility and hydration facility are comprised in the macro structure. Each biopharmaceutical manufacturing facility is comprised in a respective micro node, and a control facility in the macro structure is configured to control interoperability of the macro structure and the micro nodes by means of a network spine interconnecting the macro structure with each micro node.Type: ApplicationFiled: June 20, 2019Publication date: October 3, 2019Applicant: GE Healthcare Bio-Sciences Corp.Inventors: Steve Robert Gravallese, Jason Naylor, Edwin Brian Taylor, Sven Frie, Patrick McMahon
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Patent number: 10372100Abstract: The present disclosure relates to a manufacturing system, method and control circuitry for quality assured manufacturing of at least two biopharmaceutical products. The manufacturing system comprises a warehouse facility, a hydration facility, and at least two biopharmaceutical manufacturing facilities, wherein the warehouse facility and hydration facility are comprised in the macro structure. Each biopharmaceutical manufacturing facility is comprised in a respective micro node, and a control facility in the macro structure is configured to control interoperability of the macro structure and the micro nodes by means of a network spine interconnecting the macro structure with each micro node.Type: GrantFiled: August 29, 2016Date of Patent: August 6, 2019Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Steve Robert Gravallese, Jason Naylor, Edwin Brian Taylor, Sven Frie, Patrick McMahon
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Publication number: 20190136206Abstract: Disclosed herein is provided a virus purification and formulation process for purifying a flavivirus represented by one of a Yellow Fever Virus, Japanese Encephalitis virus, Dengue virus, and West Nile virus. The highly purified flavivirus virus product is characterized as having a low level of sucrose without significant virus loss such as that which is typically encountered by prior art virus purification processes. The disclosed process captures and purifies the virus, separating it from the host cell proteins and DNA, and leaving the host cell proteins and DNA behind. The process also can be used to inactivate and/or concentrate the virus sufficiently for use in formulations.Type: ApplicationFiled: December 21, 2018Publication date: May 9, 2019Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: JOHN J. VICALVI, JR., EDWARD G. HAYMAN, JOSEPH MAKOWIECKI
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Patent number: 10241050Abstract: Systems and methods for executing super-resolution microscopy of a specimen with most of the image processing performed in a camera of a fluorescence microscopy instrument are described. In one aspect, the camera includes one or more processors to execute machine-readable instructions that control excitation light output from a multi-channel light source, control capture of intermediate images of the specimen, and perform image processing of the intermediate images to produce a final super-resolution image of the specimen.Type: GrantFiled: May 2, 2017Date of Patent: March 26, 2019Assignee: GE Healthcare Bio-Sciences Corp.Inventor: Paul C. Goodwin
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Patent number: 10234852Abstract: A bioreactor control system comprises a batch server for controlling a bioreactor system in response to a recipe, a batch software system for generating a control sequence for the bioreactor system via the batch server for implementing the recipe, and a recipe conversion system that inputs the recipe into the batch software system. Preferably, the recipe conversion system reads a word processor file containing the recipe and interprets styles applied to text in the word processor file as indicating equipment and phases of the recipe to the recipe conversion system. Generally, the bioreactor system includes one or more bioreactors and additional hardware to perform the upstream and downstream processing. The document properties of the word processor file containing the recipe are applied as header information for the recipe input into the batch software system.Type: GrantFiled: December 13, 2016Date of Patent: March 19, 2019Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventor: David Mills
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Publication number: 20190078046Abstract: A bioreactor system and packaging is provided. The bioreactor system includes a vessel for housing biomaterials for processing and a support structure. The vessel includes a flexible material defining a chamber and a mixing system positioned within the chamber. The mixing system includes an agitator for imparting motion and mixing to the contents of the vessel and includes a base affixed to the flexible material at a base section of the chamber, a shaft moveably mounted in the base and extending from the base into the chamber and at least one mixing element mounted to the shaft, the shaft configured to be driven by a motor magnetically coupled to the shaft and external to the lower portion of the chamber. The support structure is connected to the mixing system such that the shaft is moveable therein and configured to cooperate with an external structure to provide support for the shaft.Type: ApplicationFiled: October 11, 2016Publication date: March 14, 2019Applicant: GE Healthcare Bio-Sciences Corp.Inventors: Steven James Forsberg, Ralph Stankowski, Colin R. Tuohey
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Patent number: 10221383Abstract: A system for condensing moisture in a moist gas stream entering or leaving a bioreactor includes a condenser container, the condenser container comprising: an outer wall surface and an inner wall surface, the inner wall surface defining an interior chamber for holding a fluid; and a first fitment attached to the outer wall surface and forming a first port configured to allow the moist gas stream to flow into the interior chamber; a second fitment attached to the outer wall surface and forming a second port configured to allow a dried gas to flow from the interior chamber and out of the second port; and a cooling device in contact with at least one portion of the outer wall surface and arranged to cool the at least one portion of the outer wall surface.Type: GrantFiled: September 8, 2016Date of Patent: March 5, 2019Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Richard Damren, Colin Touhey, Thomas Erdenberger, Michael Fisher, Geoffrey Hodge, Patrick Guertin, Parrish Galliher
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Patent number: 10196615Abstract: Disclosed herein is provided a virus purification and formulation process for purifying a flavivirus represented by one of a a Yellow Fever Virus, Japanese Encephalitis virus, Dengue virus, and West Nile virus. The highly purified flavivirus virus product is characterized as having a low level of sucrose without significant virus loss such as that which is typically encountered by prior art virus purification processes. The disclosed process captures and purifies the virus, separating it from the host cell proteins and DNA, and leaving the host cell proteins and DNA behind. The process also can be used to inactivate and/or concentrate the virus sufficiently for use in formulations.Type: GrantFiled: May 24, 2016Date of Patent: February 5, 2019Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: John J. Vicalvi, Jr., Edward G. Hayman, Joseph Makowiecki
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Patent number: 10190087Abstract: Disclosed herein is a single use, controlled environment manufacturing module in the form of a sterile sealed bag formed of a substantially flexible material, such that the bag can be inflated and deflated for transport and/or disposal. The flexible bag has one or more access ports and connectors to accommodate a variety of biochemical or pharmaceutical manufacturing processes to be carried out within the flexible bag. The interiors of one or more disclosed modules can be connected, forming a module train.Type: GrantFiled: September 20, 2012Date of Patent: January 29, 2019Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Parrish M. Galliher, Michael Fisher, Geoffrey L. Hodge
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Patent number: 10184949Abstract: The present invention provides improved methods, facilities and systems for parallel processing of biological cellular samples in an efficient and scalable manner. The invention enables parallel processing of biological cellular samples, such as patient samples, in a space and time efficient fashion. The methods, facilities and systems of the invention find particular utility in processing patient samples for use in cell therapy.Type: GrantFiled: July 21, 2015Date of Patent: January 22, 2019Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Firman Ghouze, Philip Vanek
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Patent number: D858264Type: GrantFiled: July 31, 2017Date of Patent: September 3, 2019Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Eric Tenander, Ethan Michael Barrieau, Ralph Stankowski
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Patent number: D858265Type: GrantFiled: July 31, 2017Date of Patent: September 3, 2019Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Eric Tenander, Ethan Michael Barrieau, Ralph Stankowski
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Patent number: D859136Type: GrantFiled: July 31, 2017Date of Patent: September 10, 2019Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Eric Tenander, Ethan Michael Barrieau, Ralph Stankowski
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Patent number: D859137Type: GrantFiled: January 30, 2018Date of Patent: September 10, 2019Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Eric Tenander, Ethan Michael Barrieau, Ralph Stankowski
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Patent number: D859970Type: GrantFiled: July 31, 2017Date of Patent: September 17, 2019Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Eric Tenander, Ethan Michael Barrieau, Ralph Stankowski
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Patent number: D859971Type: GrantFiled: July 31, 2017Date of Patent: September 17, 2019Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Eric Tenander, Ethan Michael Barrieau, Ralph Stankowski
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Patent number: D865507Type: GrantFiled: January 30, 2018Date of Patent: November 5, 2019Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Eric Tenander, Ethan Michael Barrieau, Ralph Stankowski