Patents Assigned to GEARBOX, LLC
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Patent number: 10610635Abstract: Devices, systems, or methods are disclosed herein for treatment of disease in a vertebrate subject. The device can include a quasi-planar substrate; and one or more laterally-mobile effector molecule types at least partially embedded within the quasi-planar substrate, wherein the one or more laterally-mobile effector molecule types is configured to interact with one or more cell types. The device can further include one or more sensors configured to detect at least one aspect of an interaction between the at least one of the one or more laterally-mobile effector molecule types and the one or more cell types; and a controller in communication with the one or more sensors, wherein the controller is configured to responsively initiate modification of at least one of the one or more laterally-mobile effector molecule types, the quasi-planar substrate, and the one or more cell types.Type: GrantFiled: July 11, 2018Date of Patent: April 7, 2020Assignee: Gearbox LLCInventors: Roderick A. Hyde, Lowell L. Wood, Jr.
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Patent number: 10546652Abstract: An apparatus, device, methods, computer program product, and system are described that accept an input defining at least one medical condition; identify within one or more sets of study data at least one agent having a defined level of efficacy in treating the at least one medical condition; identify at least one subpopulation having a defined tolerance for at least one adverse event associated with administration of the at least one agent, the at least one subpopulation exhibiting at least some defined level of efficacy upon administration of the at least one agent to the subpopulation; and present the at least one agent in response to said identification of the at least one subpopulation.Type: GrantFiled: September 29, 2006Date of Patent: January 28, 2020Assignee: Gearbox LLCInventors: Edward K. Y. Jung, Royce A. Levien, Robert W. Lord, Mark A. Malamud, Lowell L. Wood, Jr.
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Patent number: 10503872Abstract: Methods, apparatuses, computer program products, devices and systems are described that accepting an input identifying at least one treatment target in search of an agent; accessing at least one dataset containing at least one agent for use in the context of the at least one treatment target; applying at least one filter criterion to the at least one dataset to identify a subset of the at least one dataset, the subset of the at least one dataset associated with a defined level of at least one adverse event associated with administration of the at least one agent; and presenting the at least one agent in response to the subset of the at least one dataset.Type: GrantFiled: December 27, 2006Date of Patent: December 10, 2019Assignee: Gearbox LLCInventors: Edward K. Y. Jung, Royce A. Levien, Robert W. Lord, Mark A. Malamud, Lowell L. Wood, Jr.
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Patent number: 10460080Abstract: An apparatus, device, methods, computer program product, and system are described that provide a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, the first possible outcome based on at least one dataset associated with at least one predictive basis, and apply a filter criteria to the at least one dataset to provide a modified graphical illustration of a second possible outcome of the use of the treatment parameter.Type: GrantFiled: December 21, 2005Date of Patent: October 29, 2019Assignee: Gearbox, LLCInventors: Edward K. Y. Jung, Royce A. Levien, Robert W. Lord, Mark A. Malamud, John D. Rinaldo, Jr., Lowell L. Wood, Jr.
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Patent number: 10448815Abstract: A method and system are described for generating a signal indicative of an intravascular image received at least partly via a light transducer and invoking circuitry for passing the generated signal out of a subject's body.Type: GrantFiled: May 4, 2012Date of Patent: October 22, 2019Assignee: GEARBOX, LLCInventors: Edward K. Y. Jung, Eric C. Leuthardt, Royce A. Levien, Robert W. Lord, Mark A. Malamud, John D. Rinaldo, Jr., Clarence T. Tegreene, Lowell L. Wood, Jr.
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Patent number: 10426857Abstract: Systems, devices, methods, and compositions are described for providing an actively controllable implant configured to, for example, monitor, treat, or prevent microbial growth or adherence to the implant.Type: GrantFiled: September 8, 2016Date of Patent: October 1, 2019Assignee: Gearbox, LLCInventors: Edward S. Boyden, Roy P. Diaz, Roderick A. Hyde, Jordin T. Kare, Elizabeth A. Sweeney, Lowell L. Wood
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Patent number: 10409088Abstract: Various embodiments of methods and systems for improving and enhancing vision are disclosed. Adjustable lenses or optical systems may be used to provide adaptive vision modification. In some embodiments, vision modification may be responsive to the current state of the user's visual system. Certain embodiments provide correction of the subject's near and far vision. Other embodiments provide enhancement of vision beyond the physiological ranges of focal length or magnification.Type: GrantFiled: October 3, 2016Date of Patent: September 10, 2019Assignee: Gearbox, LLCInventors: W. Daniel Hillis, Roderick A. Hyde, Muriel Y. Ishikawa, Edward K. Y. Jung, Nathan P. Myhrvold, Clarence T. Tegreene, Lowell L. Wood, Jr.
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Patent number: 10319471Abstract: Systems and methods are described relating to detecting an indication of at least one attribute of an individual; accepting sensor data about the individual; and presenting a set of health care options at least partially based on the detecting an indication of at least one attribute of the individual and the accepting sensor data about the individual.Type: GrantFiled: September 21, 2017Date of Patent: June 11, 2019Assignee: Gearbox LLCInventors: Shawn P. Firminger, Jason Garms, Roderick A. Hyde, Edward K. Y. Jung, Chris Demetrios Karkanias, Eric C. Leuthardt, Royce A. Levien, Richard T. Lord, Robert W. Lord, Mark A. Malamud, John D. Rinaldo, Jr., Clarence T. Tegreene, Kristin M. Tolle, Lowell L. Wood, Jr.
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Patent number: 10296720Abstract: The present disclosure relates to computational systems and methods related to nutraceuticals.Type: GrantFiled: June 28, 2007Date of Patent: May 21, 2019Assignee: Gearbox LLCInventors: Edward K. Y. Jung, Royce A. Levien, Robert W. Lord, Mark A. Malamud, John D. Rinaldo, Jr., Clarence T. Tegreene, Lowell L. Wood, Jr.
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Patent number: 10095836Abstract: Methods, apparatuses, computer program products, devices and systems are described that are configured for accepting an input identifying at least one treatment target in search of an agent; accessing at least one dataset containing at least one agent for use in the context of the at least one treatment target; applying at least one filter criterion to at least one dataset to identify a subset of the at least one dataset, the subset of the at least one dataset associated with a defined level of at least one adverse event associated with administration of the at least one agent; and presenting the at least one agent in response to the subset of the at least one dataset.Type: GrantFiled: June 22, 2007Date of Patent: October 9, 2018Assignee: GEARBOX LLCInventors: Edward K. Y. Jung, Royce A. Levien, Robert W. Lord, Mark A. Malamud, Lowell L. Wood, Jr.
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Patent number: 10092692Abstract: Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.Type: GrantFiled: October 13, 2017Date of Patent: October 9, 2018Assignee: Gearbox, LLCInventors: Ralph G. Dacey, Jr., Gregory J. Della Rocca, Colin P. Derdeyn, Joshua L. Dowling, Eleanor V. Goodall, Roderick A. Hyde, Muriel Y. Ishikawa, Jordin T. Kare, Eric C. Leuthardt, Nathan P. Myhrvold, Michael A. Smith, Lowell L. Wood, Jr., Victoria Y. H. Wood, Gregory J. Zipfel
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Patent number: 10080823Abstract: The present disclosure relates to substrates associated with nitric oxide.Type: GrantFiled: November 17, 2010Date of Patent: September 25, 2018Assignee: Gearbox LLCInventors: Roderick A. Hyde, Muriel Y. Ishikawa, Leif T. Stordal, Lowell L. Wood, Jr.
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Patent number: 10068303Abstract: Methods, apparatuses, computer program products, devices and systems are described that accepting an input identifying a treatment target in search of an agent, the input associated with at least one query parameter; determining, based on the input, at least one subset of study data for which at least one adverse event profile associated with administration of at least one agent is acceptable within a defined limit relative to a population for which the at least one adverse event profile is unacceptable with respect to the defined limit; and presenting the agent, based on the at least one subset and the at least one query parameter.Type: GrantFiled: June 4, 2007Date of Patent: September 4, 2018Assignee: Gearbox LLCInventors: Edward K. Y. Jung, Royce A. Levien, Robert W. Lord, Mark A. Malamud, Lowell L. Wood, Jr.
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Patent number: 10042980Abstract: In one aspect, a method related to health-related data management. In addition to the foregoing, other method and system and program product aspects are described in the claims, drawings, and text forming a part of the present application.Type: GrantFiled: November 17, 2005Date of Patent: August 7, 2018Assignee: Gearbox LLCInventors: Edward K. Y. Jung, Royce A. Levien, Robert W. Lord, Mark A. Malamud, John D. Rinaldo, Jr., Lowell L. Wood, Jr.
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Patent number: 10032060Abstract: Described embodiments include a system, method, and computer program product. In a described system, a receiver circuit receives at least two reference images of a patient body part. Each reference image includes a respective landmark subsurface feature of the patient body part, and each imaged landmark subsurface feature has a respective spatial relationship to a respective region of a surface of the patient body part imaged during a medical examination. A feature matching circuit determines a correspondence between (x) each atlas landmark subsurface feature of the patient body part included in a landmark subsurface feature atlas and (y) each respective imaged landmark subsurface feature. A reporting circuit generates informational data reporting a depiction of an area of the surface of the patient body part by at least two adjacent imaged regions of the surface of the patient body part. A communication circuit outputs the informational data.Type: GrantFiled: February 4, 2015Date of Patent: July 24, 2018Assignee: GEARBOX, LLCInventors: Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Erez Lieberman Aiden, Dennis J. Rivet, Elizabeth A. Sweeney, Lowell L. Wood, Jr.
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Patent number: 10022486Abstract: Devices, systems, or methods are disclosed herein for treatment of disease in a vertebrate subject. The device can include a quasi-planar substrate; and one or more laterally-mobile effector molecule types at least partially embedded within the quasi-planar substrate, wherein the one or more laterally-mobile effector molecule types is configured to interact with one or more cell types. The device can further include one or more sensors configured to detect at least one aspect of an interaction between the at least one of the one or more laterally-mobile effector molecule types and the one or more cell types; and a controller in communication with the one or more sensors, wherein the controller is configured to responsively initiate modification of at least one of the one or more laterally-mobile effector molecule types, the quasi-planar substrate, and the one or more cell types.Type: GrantFiled: April 21, 2017Date of Patent: July 17, 2018Assignee: Gearbox, LLCInventors: Roderick A. Hyde, Lowell L. Wood, Jr.
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Patent number: 10016249Abstract: An apparatus, device, methods, computer program product, and system are described that provide a graphical illustration of a first possible outcome of a use of a treatment parameter with respect to at least one body portion, the first possible outcome based on at least one dataset associated with at least one predictive basis, and apply a filter criteria to the at least one dataset to provide a modified graphical illustration of a second possible outcome of the use of the treatment parameter.Type: GrantFiled: October 23, 2006Date of Patent: July 10, 2018Assignee: Gearbox LLCInventors: Edward K. Y. Jung, Royce A. Levien, Robert W. Lord, Mark A. Malamud, John D. Rinaldo, Jr., Lowell L Wood, Jr.
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Patent number: 10001496Abstract: The present disclosure relates to methods that may be used for the detection of allergens. In some embodiments, a system includes circuitry for processing one or more samples with one or more microfluidic chips configured for analysis of one or more allergen indicators; circuitry for detecting the one or more allergen indicators; and circuitry for comparing one or more detected concentration levels of the one or more allergen indicators to one or more concentration levels of the one or more allergen indicators that results in one or more allergic responses.Type: GrantFiled: September 28, 2007Date of Patent: June 19, 2018Assignee: GEARBOX, LLCInventors: Edward K. Y. Jung, Eric C. Leuthardt, Royce A. Levien, Robert W. Lord, Mark A. Malamud, John D. Rinaldo, Jr., Lowell L. Wood, Jr.
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Patent number: 9999776Abstract: A method includes a method implemented in a medical apparatus implanted in an animal and configured to at least one of transmit or receive a communication externally of the animal. The method includes receiving a communication. The method also includes detecting an indication of a malware in the received communication. The method further includes implementing in the implanted medical device a countermeasure responsive to the detected indication of malware in the received communication.Type: GrantFiled: April 30, 2008Date of Patent: June 19, 2018Assignee: Gearbox, LLCInventors: Roderick A. Hyde, Muriel Y. Ishikawa, Eric C. Leuthardt, Michael A. Smith, Lowell L. Wood, Jr.
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Patent number: 9911165Abstract: Systems and methods are described relating to detecting an indication of at least one attribute of an individual; accepting sensor data about the individual; and presenting a set of health care options at least partially based on the detecting an indication of at least one attribute of the individual and the accepting sensor data about the individual.Type: GrantFiled: January 29, 2010Date of Patent: March 6, 2018Assignee: GEARBOX, LLCInventors: Shawn P. Firminger, Jason Garms, Roderick A. Hyde, Edward K. Y. Jung, Chris Demetrios Karkanias, Eric C. Leuthardt, Royce A. Levien, Richard T. Lord, Robert W. Lord, Mark A. Malamud, John D. Rinaldo, Jr., Clarence T. Tegreene, Kristin M. Tolle, Lowell L. Wood, Jr.