Patents Assigned to Genapsys, Inc.
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Patent number: 11332778Abstract: The disclosure provides methods and systems for nucleic acid amplification including isothermal nucleic acid amplification.Type: GrantFiled: November 25, 2019Date of Patent: May 17, 2022Assignee: GENAPSYS, INC.Inventor: Florian Oberstrass
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Patent number: 11286522Abstract: The present disclosure relates to systems and methods for high efficiency electronic sequencing of nucleic acids and molecular detection.Type: GrantFiled: August 20, 2018Date of Patent: March 29, 2022Assignee: GENAPSYS, INC.Inventor: Hesaam Esfandyarpour
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Patent number: 11155865Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.Type: GrantFiled: July 18, 2018Date of Patent: October 26, 2021Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
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Patent number: 11021748Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.Type: GrantFiled: October 10, 2019Date of Patent: June 1, 2021Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
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Patent number: 11015219Abstract: Provided herein are systems and methods for sequencing, amplifying, detecting, analyzing, and/or performing sample preparation procedures for nucleic acids and other biomolecules.Type: GrantFiled: July 28, 2017Date of Patent: May 25, 2021Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Max Greenfeld, Meysam R. Barmi, Kosar B. Parizi, Hamid Rategh, Amirhossein Samakar
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Patent number: 10900075Abstract: The present disclosure provides methods and systems for sequencing nucleic acid molecules. Methods may include sequencing double-stranded nucleic acids or single-stranded nucleic acids. Sequencing may include the use of nucleotides coupled to electrostatic moieties. The electrostatic moieties may be detected by a sensor array. The electrostatic moieties may be reversible electrostatic moieties that are cleaved from the nucleic acid molecule after incorporation of the nucleotide. The electrostatic moieties may be irreversible electrostatic moieties. Nucleotides comprising irreversible electrostatic moieties may be incorporated into the nucleic acid molecule, detected by the sensor array, and exchanged for non-detectable nucleotides.Type: GrantFiled: September 25, 2018Date of Patent: January 26, 2021Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Maryam Jouzi, Seth Stern, Paul Kenney
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Patent number: 10787705Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.Type: GrantFiled: February 14, 2018Date of Patent: September 29, 2020Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
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Patent number: 10683389Abstract: Provided herein are methods that comprise providing polymer chains comprising a plurality of reactive groups onto the surface of beads and covalent attachment of functionalized biomolecules, such as primers.Type: GrantFiled: September 18, 2017Date of Patent: June 16, 2020Assignee: GENAPSYS, INC.Inventors: Aldrich N. K. Lau, Paul M. Kenney, Henrik Persson
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Patent number: 10612091Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.Type: GrantFiled: February 22, 2019Date of Patent: April 7, 2020Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
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Patent number: 10570449Abstract: Provided herein are devices and methods suitable for sequencing, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other biomolecules.Type: GrantFiled: October 5, 2017Date of Patent: February 25, 2020Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Hamid Rategh, Meysam R. Barmi, Kosar B. Parizi, Kambiz Kaviani
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Patent number: 10544456Abstract: Provided herein are systems and methods for processing and analyzing nucleic acids and other biomolecules. Methods may include processing nucleic acid molecules in an emulsion of droplets. Methods of analyzing nucleic acid molecules may include coupling nucleic acids to a bead or other support. Methods may include analysis of nucleic acid molecules using a redox mediator. In some cases, analysis of the nucleic acid molecule includes determining a nucleotide sequence of the nucleic acid molecule.Type: GrantFiled: July 20, 2017Date of Patent: January 28, 2020Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Kosar Parizi, Saurabh Paliwal, Seth Stern, Paul Kenney, Meysam R. Barmi, Ali Nabi, Hamid Rategh
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Patent number: 10533218Abstract: The disclosure provides methods and systems for nucleic acid amplification including isothermal nucleic acid amplification.Type: GrantFiled: October 5, 2017Date of Patent: January 14, 2020Assignee: GENAPSYS, INC.Inventor: Florian Oberstrass
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Patent number: 10494672Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.Type: GrantFiled: February 22, 2019Date of Patent: December 3, 2019Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
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Patent number: 10472674Abstract: A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead is isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat.Type: GrantFiled: November 23, 2016Date of Patent: November 12, 2019Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Mark Oldham
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Patent number: 10413900Abstract: The present disclosure provides microfluidic devices, systems and methods for sample preparation and/or analysis. A microfluidic device can include a first channel having a sequence of (n) chambers each having a first volume (v). The first channel can include one or more valves at opposing ends of the first channel that fluidically isolate the first channel. The microfluidic device can further include a second channel in fluid communication with the first channel. The second channel can include at least one second chamber having a total second volume that is at least equal to the total volume of the first channel (n*v). The second channel can include one or more valves at opposing ends of the second channel that fluidically isolate the second channel from the first channel.Type: GrantFiled: December 15, 2016Date of Patent: September 17, 2019Assignee: GENAPSYS, INC.Inventors: Seth Stern, Hesaam Esfandyarpour, David Eberhart
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Patent number: 10266892Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.Type: GrantFiled: June 13, 2018Date of Patent: April 23, 2019Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
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Patent number: 10260095Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.Type: GrantFiled: June 13, 2018Date of Patent: April 16, 2019Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
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Patent number: 10125393Abstract: Provided herein are devices and methods suitable for sequencing, detecting, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other molecules. In some cases, the devices and methods provided herein are used for computation.Type: GrantFiled: December 10, 2014Date of Patent: November 13, 2018Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Meysam R. Barmi, Kosar B. Parizi, Saurabh Paliwal, Amirhossein Samakar, Seth Stern
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Patent number: 10100356Abstract: A method comprises magnetically holding a bead carrying biological material (e.g., nucleic acid, which may be in the form of DNA fragments or amplified DNA) in a specific location of a substrate, and applying an electric field local to the bead to isolate the biological material or products or byproducts of reactions of the biological material. For example, the bead isolated from other beads having associated biological material. The electric field in various embodiments concentrates reagents for an amplification or sequencing reaction, and/or concentrates and isolates detectable reaction by-products. For example, by isolating nucleic acids around individual beads, the electric field can allow for clonal amplification, as an alternative to emulsion PCR. In other embodiments, the electric field isolates a nanosensor proximate to the bead, to facilitate detection of at least one of local pH change, local conductivity change, local charge concentration change and local heat.Type: GrantFiled: September 21, 2015Date of Patent: October 16, 2018Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Mark F. Oldham, Kosar Baghbani Parizi, Eric S. Nordman
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Patent number: 10093975Abstract: The present disclosure relates to systems and methods for high efficiency electronic sequencing of nucleic acids and molecular detection. In an example embodiment of the instant disclosure, the NanoNeedle may be utilized to detect a change in impedance resulting from the modulation of the counter ion concentration or Debye length associated with a biomolecule of interest, such as DNA or protein, for an application of interest, such as DNA sequencing, DNA hybridization, or protein detection.Type: GrantFiled: December 3, 2012Date of Patent: October 9, 2018Assignee: GENAPSYS, INC.Inventor: Hesaam Esfandyarpour