Patents Assigned to Genentech, Inc.
  • Diagnostic and therapeutic methods for cancer
    Patent number: 11859252
    Abstract: The present invention provides diagnostic and therapeutic methods and compositions for cancer. The invention provides methods of determining whether an individual having a cancer is likely to respond to treatment comprising a pan-RAF dimer inhibitor and a MEK or PI3K inhibitor, methods of predicting responsiveness of an individual having a cancer to treatment comprising a pan-RAF dimer inhibitor and a MEK or PI3K inhibitor, methods of selecting a therapy for an individual having a cancer, and methods of treating an individual having cancer based on the presence of a biomarker of the invention (e.g., a KRAS activating mutation, e.g., a KRAS-G13D mutation, or an NRAS activating mutation).
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: January 2, 2024
    Assignee: Genentech, Inc.
    Inventors: Christiaan Nicolaas Klijn, Shiva Malek, Ivana Yen
  • Bioanalytical analysis of site-specific antibody drug conjugates
    Patent number: 11860156
    Abstract: Methods to rapidly and accurately detect, characterize, measure, and quantify site-specific antibody drug conjugates, that may be present in pre-clinical animal biological samples, or human biological samples, including plasma/serum and tissue samples.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: January 2, 2024
    Assignee: Genentech, Inc.
    Inventors: Martine Darwish, Surinder Kaur, Dian Su, Keyang Xu
  • COMPOSITION COMPRISING ANTIBODY THAT BINDS TO DOMAIN II OF HER2 AND ACIDIC VARIANTS THEREOF
    Publication number: 20230416401
    Abstract: A composition comprising a main species HER2 antibody that binds to domain II of HER2 and acidic variants thereof is described. Pharmaceutical formulations comprising the composition, and therapeutic uses for the composition are also disclosed.
    Type: Application
    Filed: February 9, 2023
    Publication date: December 28, 2023
    Applicant: Genentech, Inc.
    Inventors: Reed J. HARRIS, Paul MOTCHNIK
  • USE OF KLK5 ANTAGONISTS FOR THE TREATMENT OF A DISEASE
    Publication number: 20230416825
    Abstract: Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Sydrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same.
    Type: Application
    Filed: March 29, 2023
    Publication date: December 28, 2023
    Applicant: Genentech, Inc.
    Inventors: Amy Dressen, David B. Iaea, Moulay Hicham Alaoui Ismaili, Janet K. Jackman, Robert A. Lazarus, Kelly Michele Loyet, Henry R. Maun, Brian Louis Yaspan, Tangsheng Yi, Joseph R. Arron, Hilda Y Hernandez-Barry
  • TREATMENT OF OPHTHALMOLOGIC DISEASES
    Publication number: 20230416353
    Abstract: The current invention relates to the use of antibodies which bind to VEGF and ANG2 for the treatment of ophthalmologic diseases.
    Type: Application
    Filed: February 9, 2023
    Publication date: December 28, 2023
    Applicants: Hoffmann-La Roche Inc., Genentech, Inc.
    Inventors: Aaron Osborne, Jayashree Sahni, Robert James Weikert
  • Multispecific antibodies
    Patent number: 11851501
    Abstract: The invention provides multispecific antibodies and methods of making and using such antibodies.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: December 26, 2023
    Assignee: Genentech, Inc.
    Inventors: Germaine Fuh, Jenny M. Bostrom
  • Polypeptide expression systems
    Patent number: 11851661
    Abstract: The present invention relates to polypeptide expression systems and methods of using the same.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: December 26, 2023
    Assignee: Genentech, Inc.
    Inventors: Isidro Hotzel, Yonglei Shang
  • FLUORESCENT ELLMAN ASSAY FOR FREE THIOL DETECTION
    Publication number: 20230408416
    Abstract: The present disclosure relates to methods and kits for detecting a free thiol in a substrate as well as methods for quantifying the amount of free thiol in a substrate. In particular, the present disclosure provides a fluorescent Ellman assay for enhanced sensitivity of free thiol detection and quantification.
    Type: Application
    Filed: April 28, 2023
    Publication date: December 21, 2023
    Applicant: GENENTECH, INC.
    Inventors: Aron Lee, Rashmi Sharma, Justin Joo-Ho Jeong, Michael Tae-Jon Kim
  • Apparatus and methods for low-volume medicament delivery
    Patent number: 11844938
    Abstract: Apparatus and methods for delivering medicament. The apparatus may include a fitting for a fluid dispenser. The fitting may include a detent that is configured to limit insertion of the dispenser into the fitting by contacting a terminal surface of the dispenser; and a seal for sealing against the surface. The apparatus may include an insert for the fitting. The insert may include a gasket to seal against the terminal surface of the dispenser; a proximal rim to engage a lateral wall of the dispenser; and a connector fixed to the gasket and the rim. The apparatus may include a coupler to engage a pre-filled dispenser; and a body defining a passageway that is configured to be placed in fluid communication with the dispenser. The apparatus may include a dispenser that includes a detent and a seal. The detent may limit insertion of the dispenser into a fitting.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: December 19, 2023
    Assignee: Genentech, Inc.
    Inventors: Lionel Vedrine, Ariel Waitz
  • Anti-Ly6G6D antibodies and methods of use
    Patent number: 11845799
    Abstract: Provided herein are anti-Ly6G6D (lymphocyte antigen 6 complex, locus G61) antibodies and methods of using the same.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: December 19, 2023
    Assignee: Genentech, Inc.
    Inventors: WeiYu Lin, Christoph Spiess, Liping Sun, Yan Wu, Cecilia P. C. Chiu, Walter Christian Darbonne, Michael Andrew Dillon
  • COMPLEMENT COMPONENT C1S INHIBITORS FOR TREATING A NEUROLOGICAL DISEASE, AND RELATED COMPOSITIONS, SYSTEMS AND METHODS OF USING SAME
    Publication number: 20230399643
    Abstract: The present invention relates to complement component 1s (C1S) inhibitors for use in treatment of neurological diseases. The invention in particular relates to the use of C1S inhibitors for down-regulation of C1S expression. The invention also relates to nucleic acid molecules, which are complementary to C1S and capable of reducing the level of an C1S mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment of neurological diseases.
    Type: Application
    Filed: November 9, 2022
    Publication date: December 14, 2023
    Applicant: Genentech, Inc.
    Inventors: Alexander MUNK, Helene M. GYLLING, Jesse Eric HANSON, Lukasz J. KIELPINSKI
  • 1-(2-(4-CYCLOPROPYL-1H-1,2,3-TRIAZOL-1-YL)ACETYL)-4-HYDROXY-N-(BENZYL)PYRROLIDIN E-2-CARBOXAMIDE DERIVATIVES AS VHL INHIBITORS FOR THE TREATMENT OF ANEMIA AND CANCER
    Publication number: 20230391766
    Abstract: The present disclosure relates to compounds comprising a VHL ligand moiety and to methods of using such compounds as ligands of VHL. The present disclosure further relates to the use of the compounds described herein, or pharmaceutical compositions thereof, to prevent and/or treat a range of diseases, disorders, and conditions.
    Type: Application
    Filed: May 9, 2023
    Publication date: December 7, 2023
    Applicant: Genentech, Inc.
    Inventors: Jakob FUHRMANN, Hao WU, Wayne J. FAIRBROTHER
  • Bicyclic ketone compounds and methods of use thereof
    Patent number: 11834461
    Abstract: The invention provides novel compounds having the general formula I: wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: December 5, 2023
    Assignee: Genentech, Inc.
    Inventors: Snahel Patel, Gregory Hamilton, Guiling Zhao, Huifen Chen, Blake Daniels, Craig Stivala
  • Multiplexed target-binding candidate screening analysis
    Patent number: 11834709
    Abstract: A method and system for normalizing a polymerase chain reaction (PCR) amplification process for a plurality of samples containing DNA. Cycle data for performing the PCR amplification process is identified for the plurality of samples. The cycle data includes a corresponding cycle count for each sample of the plurality of samples. The plurality of samples is sorted into a plurality of bins based on the cycle data such that cycle count variation between bins of the plurality of bins is reduced. A bin cycle count is assigned to each bin of the plurality of bins. The bin cycle count is unique to each bin of the plurality of bins. Identification information is generated for the bins. An output for performing a PCR amplification of the plurality of samples is generated using the bins and the bin cycle count for each bin of the plurality of bins.
    Type: Grant
    Filed: October 14, 2021
    Date of Patent: December 5, 2023
    Assignee: Genentech, Inc.
    Inventors: Christian N. Cunningham, Kenneth Karl Hallenbeck
  • Polysorbate mixtures having modified fatty acid ester distribution
    Patent number: 11833206
    Abstract: The present disclosure provides polysorbate 20 compositions with particular fatty acid ester concentrations. In some embodiments, they may be used in pharmaceutical formulations, for example, to improve stability.
    Type: Grant
    Filed: September 23, 2021
    Date of Patent: December 5, 2023
    Assignee: Genentech, Inc.
    Inventors: Sandeep Yadav, Nidhi Doshi, Tamanna Shobha, Anthony Tomlinson, Amit Srivastava
  • PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES
    Publication number: 20230383004
    Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.
    Type: Application
    Filed: March 31, 2023
    Publication date: November 30, 2023
    Applicant: Genentech, Inc.
    Inventors: Yung-Hsiang KAO, Michael W. LAIRD, Melody Trexler SCHMIDT, Rita L. WONG, Daniel P. HEWITT
  • TREATMENT OF BREAST CANCER USING COMBINATION THERAPIES COMPRISING GDC-9545 AND IPATASERTIB
    Publication number: 20230381156
    Abstract: Provided herein are combination therapies comprising GDC-9545 and ipatasertib for treating locally advanced breast cancer or metastatic breast cancer.
    Type: Application
    Filed: August 15, 2023
    Publication date: November 30, 2023
    Applicant: Genentech, Inc.
    Inventors: Ciara METCALFE, Kui LIN, Marc Antoine HAFNER
  • TREATMENT OF BREAST CANCER USING COMBINATION THERAPIES COMPRISING GDC-9545 AND ABEMACICLIB OR RIBOCICLIB
    Publication number: 20230381154
    Abstract: Provided herein are combination therapies comprising GDC-9545 and abemaciclib or ribociclib for treating locally advanced breast cancer or metastatic breast cancer.
    Type: Application
    Filed: August 15, 2023
    Publication date: November 30, 2023
    Applicant: Genentech, Inc.
    Inventors: Ciara METCALFE, Pablo Diego PEREZ-MORENO, Xiaojing WANG
  • TREATMENT OF BREAST CANCER USING COMBINATION THERAPIES COMPRISING GDC-9545 AND GDC-0077
    Publication number: 20230381155
    Abstract: Provided herein are combination therapies comprising GDC-9545 and GDC-0077 for treating locally advanced breast cancer or metastatic breast cancer.
    Type: Application
    Filed: August 15, 2023
    Publication date: November 30, 2023
    Applicant: Genentech, Inc.
    Inventors: Ciara METCALFE, Xiaojing WANG, Wei ZHOU
  • ESTIMATION OF MECHANISTIC CHROMATOGRAPHY MODEL UNCERTAINTY
    Publication number: 20230385475
    Abstract: A method, system, and non-transitory computer readable medium for estimating mechanistic chromatography model uncertainty. A mechanistic model of chromatography that comprises a plurality of parameters is received. For each of the plurality of parameters, a corresponding region of values is identified based on a relationship between values for the plurality of parameters. Each parameter of the plurality of parameters is sampled within the corresponding region of values for each parameter to form a plurality of simulation sets. An uncertainty for the mechanistic model is quantified using the plurality of simulation sets.
    Type: Application
    Filed: August 10, 2023
    Publication date: November 30, 2023
    Applicant: GENENTECH, INC.
    Inventors: Jessica Yang LYALL, Connor James THOMPSON, Sean Mackenzie BURGESS