Abstract: This invention relates generally to the field of homocysteine detection. In particular, the invention provides a method for determining homocysteine presence or concentration in samples, which method comprises: contacting a sample containing or suspected of containing Hcy with a Hcy co-substrate and a Hcy converting enzyme in a Hcy conversion reaction to form a Hcy conversion product and a Hcy co-substrate conversion product; and assessing the Hcy co-substrate conversion product to determine the presence, absence and/or amount of the Hcy in the sample. The Hcy co-substrate conversion product may be assessed directly, or it may be assessed by further conversion of the Hcy co-substrate conversion product into another material by the action of one or more additional enzymes. A kit for assaying homocysteine based on the same principle is also provided.
Abstract: A system for generating an electrical current in a circuit includes a rotor, a stator and a motor for rotating the rotor about a rotation axis. A plurality of permanent magnets are mounted on the rotor and radially distanced from the rotation axis. With this structure, the permanent magnets rotate with the rotor to establish a time-varying magnetic field. A winding is attached to the stator, connected to the circuit and immersed in the time-varying magnetic field generated by the permanent magnets. In one implementation, a switch is provided to reconfigure the circuit between a first, open-circuit configuration in which little or no current flows through the circuit, and a second closed-circuit configuration in which a current is generated at the winding for flow through the circuit.
Abstract: A method of data transmission according to one embodiment of the invention includes transmitting a plurality of bursts to transmit data, each burst occupying at least one of a plurality of frequency bands. Specifically, a bandwidth of at least one of the plurality of bursts is at least two percent of the center frequency of the burst. In one preferred embodiment, a bandwidth of at least one of the plurality of bursts is at least 100 MHz. In another preferred embodiment, each burst occupies at least one of the plurality of frequency bands, but less than all of the plurality of frequency bands.
Type:
Grant
Filed:
May 17, 2005
Date of Patent:
October 14, 2008
Assignee:
General Atomics
Inventors:
Gerald D. Rogerson, Jason L. Ellis, David S. Furuno, Michael L. Walker, Stephan W. Gehring
Abstract: A method and apparatus for operation in a multi-frequency band wideband system in the presence of an interference, the method comprising the steps: receiving signaling in a plurality of wideband frequency sub-bands, each wideband frequency sub-band having a different center frequency, wherein a bandwidth of each wideband frequency sub-band is at least 2 percent of a center frequency of the wideband frequency sub-band; detecting an interfering signal having signal energy in a portion of a respective sub-band of the wideband frequency sub-bands; modifying at least one of a center frequency and a bandwidth of the respective sub-band in order to operate in the presence of the interfering signal; and instructing a transmitting device transmitting the signaling to transmit subsequent signaling accounting for the modification of the center frequency of the respective sub-band.
Type:
Grant
Filed:
February 20, 2003
Date of Patent:
July 22, 2008
Assignee:
General Atomics
Inventors:
Stephan W. Gehring, Jason L. Ellis, Susan C. Lin, Gerald D. Rogerson
Abstract: A magnetic test apparatus, in accordance with one embodiment, comprising a rotor coupled to a drive shaft, wherein the drive shaft is mechanically coupled to a drive system; a stator coupled to at least one brush holder; at least one brush held by the brush holder, wherein the brush is held in contact with the rotor; a housing for supporting the rotor and the stator; and a magnet for providing a magnetic field in the vicinity of the at least one brush.
Type:
Application
Filed:
October 13, 2006
Publication date:
June 26, 2008
Applicant:
GENERAL ATOMICS
Inventors:
Zbigniew S. Piec, David E. Corbett, Alan R. Langhorn
Abstract: The present invention relates to methods for assaying inhibitors for S-adenosylhomocysteine (SAH) hydrolases and assaying inhibitors for S-adenosylmethionine (SAM)-dependent methyltransferases. The methods are amenable for use in high throughput formats. Kits for performing the methods are also provided.
Type:
Grant
Filed:
April 30, 2004
Date of Patent:
June 10, 2008
Assignee:
General Atomics
Inventors:
Chong-Sheng Yuan, Qi-Zhuang Ye, Sheng-Xue Xie
Abstract: A method of data transmission according to one embodiment of the invention includes encoding a set of data values to produce a corresponding series of ordered n-tuples. The method also includes transmitting, according to the series of ordered n-tuples, a plurality of bursts over a plurality n of frequency bands. Specifically, for each of the plurality of bursts, a frequency band occupied by the burst is indicated by the order within its n-tuple of an element corresponding to the burst. A bandwidth of at least one of the plurality of bursts is at least two percent of the center frequency of the burst. Information is encoded into a polarity of at least one of the plurality of bursts.
Type:
Application
Filed:
January 22, 2008
Publication date:
June 5, 2008
Applicant:
GENERAL ATOMICS
Inventors:
Gerald D. Rogerson, David S. Furuno, Stephan W. Gehring, Michael L. Walker, Roberto Aiello
Abstract: The present invention provides a method for assaying alpha-methylacyl-CoA racemase activity. In the assay, a sample containing an alpha-methylacyl-CoA racemase or suspected of containing an alpha-methylacyl-CoA racemase is contacted with (2R)-2-methylacyl-CoA. If alpha-methylacyl-CoA racemase is present in the sample, (2R)-2-methylacyl-CoA is converted into (2S)-2-methylacyl-CoA. The method then utilizes a cycling reaction system between (2S)-2-methylacyl-CoA and trans-2,3-dehydroacyl-CoA to generate a detectable signal that corresponds to the alpha-methylacyl-CoA racemase activity. Kits for assaying alpha-methylacyl-CoA racemase based on the same principle are also provided.
Abstract: The present invention provides a method for assaying alpha-methylacyl-CoA racemase activity. In the assay, a sample containing an alpha-methylacyl-CoA racemase or suspected of containing an alpha-methylacyl-CoA racemase is contacted with (2R)-pristanoyl-CoA. If alpha-methylacyl-CoA racemase is present in the sample, (2R)-pristanoyl-CoA is converted into (2S)-pristanoyl-CoA. The method then utilizes a cycling reaction system between (2S)-pristanoyl-CoA and trans-2,3-dehydropristanoyl-CoA to generate a detectable signal that corresponds to the alpha-methylacyl-CoA racemase activity. Kits for assaying alpha-methylacyl-CoA racemase based on the same principle are also provided.
Abstract: The invention relates generally to the field of potassium ion detection. In particular, the invention provides kits for assaying for potassium ions in a sample using a potassium-dependent urea amidolyase (UAL) enzyme.
Abstract: A laser device which may be used as an oscillator or amplifier comprising a chamber having a volume formed therein and a gain medium within the volume. The gain medium comprises a solid-state element containing active laser ion within the volume. A cooling fluid flows about the solid-state element and a semiconductor laser diode provides optical pump radiation into the volume of the laser chamber such that laser emission from the device passes through the gain medium and the fluid. The laser device provides the advantages of a solid-state gain medium laser (e.g., diode-pumping, high power density, etc), but enables operation at higher average power and beam quality than would be achievable from a pure solid-state medium.
Type:
Grant
Filed:
September 5, 2006
Date of Patent:
April 29, 2008
Assignee:
General Atomics
Inventors:
Michael D. Perry, Paul S. Banks, Jason Zweiback, Robert W. Schleicher
Abstract: A system for testing radar in accordance with one embodiment comprising a target motion platform; a target motion platform controller for controlling motion of the platform; a radar responsive tag and a delay line located on the target motion platform; the radar which is being tested; and a motion measurement simulator for inputting data to the radar electronics assembly to simulate movement of the radar. In some embodiments the system further comprises a radar motion platform, wherein the radar electronics assembly is positioned on the radar motion platform; a radar motion platform controller for controlling the movement of the radar motion platform; and a master controller coupled to the radar motion platform controller and the target motion platform controller.
Type:
Grant
Filed:
October 19, 2005
Date of Patent:
April 29, 2008
Assignee:
General Atomics Aeronautical Systems, Inc.
Abstract: A persistent archive of a collection of data objects comprises a self-describing, infrastructure-independent representation of a logical structure for the collection and a self-describing, infrastructure-independent representation of the data objects. The archive is persistent in that it may be instantiated at an indefinite point in time in the future regardless of the state of technology at that time. A knowledge-based persistent archive of a collection of data objects comprises the foregoing two elements but also a self-describing, infrastructure-independent representation of knowledge relevant to the collection.
Type:
Grant
Filed:
December 9, 2004
Date of Patent:
March 25, 2008
Assignees:
General Atomics, Regents of the University of California
Inventors:
Reagan W. Moore, Arcot Rajasekar, Chaitanya K. Baru, Bertram Ludaescher, Amarnath Gupta, Richard J. Marciano
Abstract: A control method, apparatus, and system capable of securely distributing a shared secret network encryption key from a host to a wireless peripheral device. The sharing of the secret network encryption key is accomplished without the intervention of a man-machine interface at the peripheral. Embodiments enable a wireless device to receive and store multiple encryption keys, to select the appropriate encryption key depending on the network in range of the device, and thus to freely associate with multiple networks.
Type:
Application
Filed:
November 13, 2007
Publication date:
March 20, 2008
Applicant:
GENERAL ATOMICS
Inventors:
Stephan Gehring, Daniel Peters, Jason Ellis, Satish Ananthakrishnan
Abstract: A capacitor based pulse forming network includes a plurality of inductors adapted to be coupled to a load, a plurality of capacitor units, and a plurality of switches. Each switch couples a respective capacitor unit to a respective inductor. Multiple capacitor units are coupled to each inductor by separate switches and are adapted to be switched to a closed position to discharge the respective capacitor unit for a time interval of less than about 50 milliseconds. The plurality of switches are adapted to non-simultaneously discharge at least some of the multiple capacitor units to provide non-simultaneous pulses through a given inductor to the load and not through other inductors.
Abstract: A method and apparatus for operation in a multi-frequency band system in the presence of an interference, the method comprising the steps of: receiving signaling in a plurality of wideband frequency sub-bands, each wideband frequency sub-band having a different center frequency, wherein a bandwidth of each wideband frequency sub-band is at least 2 percent of a center frequency of the wideband frequency sub-band; detecting an interfering signal having signal energy in a portion of a respective sub-band of the wideband frequency sub-bands; deciding to discontinue use of the respective sub-band; and instructing a transmitting device transmitting the signaling to transmit subsequent signaling in any except the respective sub-band of the plurality of wideband frequency sub-bands.
Type:
Grant
Filed:
February 20, 2003
Date of Patent:
March 11, 2008
Assignee:
General Atomics
Inventors:
Michael L. Walker, David S. Furuno, Stephan W. Gehring, Gerald D. Rogerson, Susan C. Lin
Abstract: A MAGLEV guideway module which can be supported by vertical columns to create a section of an elevated MAGLEV guideway is disclosed. The module includes a deck and an elongated box beam that are form cast together in a unitary monolithic construction and made of lightweight, steel reinforced concrete. Functionally, a plurality of modules cooperate to form an elevated levitation track that supports the operational electromagnetic guideway components and is designed to support the weight of a MAGLEV vehicle. For the module, the beam can be an elongated, hollow beam, such as a box beam, which is made of a molded, pre-stressed concrete. A molded-concrete transverse deck is integrally formed on the hollow beam. The deck includes first and second cantilevers that each extend from the beam in opposite directions. Together, the cantilevers and beam establish a substantially flat deck surface over which a MAGLEV vehicle can travel.
Abstract: An imaging system and method for dual polarization imaging is provided. In one implementation, an imaging system includes a field stop located at a first image plane for limiting an incident light ray bundle passing through an aperture thereof and a polarization discriminating element adapted to separate the incident light ray bundle into a first ray bundle having a first polarization traveling in a first direction and a second ray bundle having a second polarization traveling in a second direction. The system also includes an image detector located at a second image plane to receive the first and second ray bundles such that the first ray bundle forms a first image at a first region of the image detector and the second ray bundle forming a second image at a second region the image detector, the first and second images laterally displaced from each other at the second image plane.
Abstract: A method of data transmission according to one embodiment of the invention includes encoding a set of data values to produce a corresponding series of ordered n-tuples. The method also includes transmitting, according to the series of ordered n-tuples, a plurality of bursts over a plurality n of frequency bands. Specifically, for each of the plurality of bursts, a frequency band occupied by the burst is indicated by the order within its n-tuple of an element corresponding to the burst. A bandwidth of at least one of the plurality of bursts is at least two percent of the center frequency of the burst. Information is encoded into a polarity of at least one of the plurality of bursts.
Type:
Grant
Filed:
February 20, 2003
Date of Patent:
January 22, 2008
Assignee:
General Atomics
Inventors:
Gerald D. Rogerson, David S. Furuno, Stephan W. Gehring, Michael L. Walker, Roberto Aiello
Abstract: A control method, apparatus, and system capable of securely distributing a shared secret network encryption key from a host to a wireless peripheral device. The sharing of the secret network encryption key is accomplished without the intervention of a man-machine interface at the peripheral. Embodiments enable a wireless device to receive and store multiple encryption keys, to select the appropriate encryption key depending on the network in range of the device, and thus to freely associate with multiple networks.
Type:
Grant
Filed:
December 21, 2001
Date of Patent:
December 18, 2007
Assignee:
General Atomics
Inventors:
Stephan Walter Gehring, Daniel Paul Peters, Jason Lee Ellis, Satish Ananthakrishnan