Patents Assigned to General Biotechnology, LLC
-
Patent number: 10271543Abstract: A fluid sample vessel includes inlet and vent tube fittings formed at one end of a container with an opposite open end closed by a needle septum. A support cap is removably engaged to the container to support the container and protect terminal ends of inlet and vent tubular branches coupled to the fittings. The support cap includes a pair of opposite legs with outwardly directed tabs for mounting within a centrifuge while supporting the cryopreservation container.Type: GrantFiled: December 14, 2016Date of Patent: April 30, 2019Assignee: Cook General Biotechnology LLCInventor: Erik John Woods
-
Patent number: 9877475Abstract: An auto-nucleating device includes a tube containing a crystalline cholesterol matrix. The ends of the tube are closed by a membrane that is impermeable to the cholesterol but permeable to liquids contained in a cryopreservation vessel. The auto-nucleating device provides a site for ice nucleation during freezing of the liquid within the vessel. One such cryopreservation vessel is a flexible vial having a closed port at one adapted to be pierced by a needle to withdraw the liquid within, and an opposite end that is initially open to receive the liquid. Another vessel includes an adaptor mounted to liquid container with a tubular branch closed by a needle septum and another tubular branch provided with a barbed fitting for engaging a flexible tube that terminates in a needle septum. In another embodiment, the vessel includes an inlet and vent branch at the top of the container and an outlet septum at a bottom opening.Type: GrantFiled: January 8, 2015Date of Patent: January 30, 2018Assignee: Cook General Biotechnology LLCInventors: Erik John Woods, John K. Critser
-
Patent number: 9757430Abstract: The present disclosure provides a composition comprising a bioactive fraction derived from a platelet concentrate, methods of making the bioactive fraction, and culture medium supplemented with the bioactive fraction. Preferred bioactive fractions have relatively low fibrinogen concentrations while retaining native growth factors in beneficial amounts and ratios.Type: GrantFiled: August 27, 2014Date of Patent: September 12, 2017Assignee: Cook General Biotechnology LLCInventors: Erik J. Woods, Christopher Taylor
-
Patent number: 9565854Abstract: A fluid sample vessel includes inlet and vent tube fittings formed at one end of a container with an opposite open end closed by a needle septum. A support cap is removably engaged to the container to support the container and protect terminal ends of inlet and vent tubular branches coupled to the fittings. The support cap includes a pair of opposite legs with outwardly directed tabs for mounting within a centrifuge while supporting the cryopreservation container.Type: GrantFiled: February 24, 2014Date of Patent: February 14, 2017Assignee: Cook General Biotechnology LLCInventor: Erik John Woods
-
Patent number: 9415146Abstract: A system for removing cryoprotectant from a cryoprotectant-containing liquid stored a container comprises a cryoprotectant removal device that receives the cryoprotectant-containing liquid and a cryoprotectant-free dialysate liquid and that is operable to transfer cryoprotectant to the dialysate liquid. A differential conductivity device is arranged to continuously measure the difference in conductivity between dialysate liquid entering the device and dialysate liquid that has received cryoprotectant transferred by the dialyzer discharged from the device. A controller is operable to control the flow of the liquids through the device in response to the measured difference in conductivity, and particularly to stop the flow of the cryoprotectant-containing liquid when the measured differential conductivity indicates that the cryoprotectant has been substantially removed from the liquid.Type: GrantFiled: March 15, 2012Date of Patent: August 16, 2016Assignee: Cook General Biotechnology LLCInventor: Alan Robert Brunsman
-
Patent number: 8936905Abstract: An auto-nucleating device includes a tube containing a crystalline cholesterol matrix. The ends of the tube are closed by a membrane impermeable to the cholesterol but permeable to liquids contained in a cryopreservation vessel. The auto-nucleating device provides a site for ice nucleation during freezing of the liquid within the vessel. The cryopreservation vessel can be a flexible vial having a closed port adapted to be pierced by a needle, and an opposite end that is initially open to receive the liquid. Another vessel includes an adaptor mounted to liquid container with a tubular branch closed by a needle septum and another tubular branch provided with a barbed fitting for engaging a flexible tube that terminates in a needle septum. Alternatively, the vessel includes an inlet and vent branch at the top of the container and an outlet septum at a bottom opening.Type: GrantFiled: July 16, 2012Date of Patent: January 20, 2015Assignee: Cook General Biotechnology LLCInventors: Erik John Woods, John K. Critser
-
Patent number: 8709797Abstract: A fluid sample vessel includes inlet and vent tube fittings formed at one end of a container with an opposite open end closed by a needle septum. A support cap is removably engaged to the container to support the container and protect terminal ends of inlet and vent tubular branches coupled to the fittings. The support cap includes a pair of opposite legs with outwardly directed tabs for mounting within a centrifuge while supporting the cryopreservation container.Type: GrantFiled: February 24, 2010Date of Patent: April 29, 2014Assignee: Cook General Biotechnology LLCInventor: Erik John Woods
-
Publication number: 20120231542Abstract: Compositions and methods for culturing therapeutic cells are provided herein. According to at least one embodiment, compositions comprising cord blood plasma and lysed platelets and methods for making and using same are provided herein.Type: ApplicationFiled: March 12, 2012Publication date: September 13, 2012Applicant: GENERAL BIOTECHNOLOGY, LLCInventors: Erik J. Woods, Sreedhar Thirumala, Dan Zhou, W. Scott Goebel
-
Publication number: 20090148934Abstract: An auto-nucleating device includes a tube containing a crystalline cholesterol matrix. The ends of the tube are closed by a membrane that is impermeable to the cholesterol but permeable to liquids contained in a cryopreservation vessel. The auto-nucleating device provides a site for ice nucleation during freezing of the liquid within the vessel. One such cryopreservation vessel is a flexible vial having a closed port at one adapted to be pierced by a needle to withdraw the liquid within, and an opposite end that is initially open to receive the liquid. Another vessel includes an adaptor mounted to liquid container with a tubular branch closed by a needle septum and another tubular branch provided with a barbed fitting for engaging a flexible tube that terminates in a needle septum. In another embodiment, the vessel includes an inlet and vent branch at the top of the container and an outlet septum at a bottom opening.Type: ApplicationFiled: December 17, 2008Publication date: June 11, 2009Applicant: General Biotechnology, LLCInventors: Erik John Woods, John K. Critser
-
Patent number: 6235463Abstract: A method is disclosed for removal of cryoprotectants from preserved suspension of biological cells and tissues. Sorbent materials are used, alone or in combination, to bind the cryoprotectant component of preserved cell suspensions with minimal osmotic stress on the preserved cells. The present method is used to effectively remove the cryoprotectants from cryopreserved cells and tissues prior to their use in transfusion, transplantation, insemination or other applications, with minimal osmotic damage due to cell swelling. Specific devices and methods are described.Type: GrantFiled: May 6, 1999Date of Patent: May 22, 2001Assignee: General Biotechnology, LLCInventors: John K. Critser, Erik J. Woods
-
Patent number: 6218101Abstract: A method to remove cryoprotectants from cryopreserved biological cells and tissues is described. Enzymes are used to convert compounds used as cryoprotectants for cells during cryopreservation to membrane impermeable products. This process effectively removes the cryoprotectant chemicals from the cells prior to their use in transfusion, transplantation, insemination or other applications, without causing osmotic damage due to cell swelling. Methods are described for subsequent removal of the enzymes and enzyme conversion products from the cell and tissue preparations.Type: GrantFiled: May 4, 1999Date of Patent: April 17, 2001Assignee: General Biotechnology, LLCInventors: John K. Critser, Erik J. Woods