Abstract: The present invention provides polypeptides comprising an immunogenic epitope of a M. vaccae protein, polynucleotides encoding such polypeptides, and fusion proteins comprising at least one such polypeptide, together with genetic constructs comprising at least one inventive polynucleotide. Compositions comprising such polypeptides, polynucleotides, fusion proteins and/or genetic constructs may be employed in the treatment of infectious diseases and immune disorders.
Type:
Grant
Filed:
June 26, 2003
Date of Patent:
March 20, 2007
Assignee:
Genesis Research and Development Corporation, Ltd.
Abstract: The present invention provides polypeptides comprising an immunogenic epitope of a M. vaccae protein, polynucleotides encoding such polypeptides, and fusion proteins comprising at least one such polypeptide, together with genetic constructs comprising at least one inventive polynucleotide. Compositions comprising such polypeptides, polynucleotides, fusion proteins and/or genetic constructs may be employed in the treatment of infectious diseases and immune disorders.
Type:
Grant
Filed:
March 14, 2002
Date of Patent:
May 9, 2006
Assignee:
Genesis Research & Development Corporation LTD
Abstract: Compositions for the treatment and/or prevention of IgE-mediated disorders in a mammal by means of RNA interference are provided, together with methods for the use of such compounds. The inventive compositions comprise a binding agent that specifically binds to a target internalizable antigen that is expressed on the surface of a target cell of interest and a genetic construct that is capable of expressing a small interfering nucleic acid molecule (siNA) that suppresses expression of a target gene within the target cell, whereby, after binding to the target antigen, the binding agent and genetic construct are internalized into the cell, and the genetic construct released.
Type:
Application
Filed:
February 22, 2005
Publication date:
September 15, 2005
Applicant:
GENESIS RESEARCH AND DEVELOPMENT CORPORATION LTD.
Inventors:
James Watson, J. Murison, Murray Grigor, Ilkka Havukkala, Grant Munro, Nevin Abernethy, Gill Webster
Abstract: Novel isolated polynucleotides and polypeptides associated with the synthesis of plant cell wall polysaccharides are provided, together with genetic constructs comprising such sequences. Methods for using such constructs for the modulation of polysaccharide content in plants are also disclosed, together with transgenic plants comprising such constructs.
Type:
Application
Filed:
March 20, 2003
Publication date:
December 11, 2003
Applicants:
GENESIS RESEARCH AND DEVELOPMENT CORPORATION LTD., RUBICON FORESTS HOLDINGS LIMITED
Abstract: Novel polynucleotides isolated from Lactobacillus rhamnosus, as well as probes and primers, genetic constructs comprising the polynucleotides, biological materials, including plants, microorganisms and multicellular organisms incorporating the polynucleotides, polypeptides expressed by the polynucleotides, and methods for using the polynucleotides and polypeptides are disclosed.
Type:
Grant
Filed:
November 28, 2000
Date of Patent:
November 5, 2002
Assignees:
Genesis Research & Development Corporation Ltd., Via Lactia BioScience (NZ) Ltd.
Inventors:
Matthew Glenn, Mark W. Lubbers, James Dekker
Abstract: Novel isolated polynucleotides and polypeptides associated with the lignin biosynthetic pathway are provided, together with constructs including such sequences. Methods for the modulation of lignin content, lignin structure and lignin composition in target organisms are also disclosed, the methods comprising incorporating one or more of the polynucleotides of the present invention into the genome of a target organism.
Type:
Grant
Filed:
July 12, 2000
Date of Patent:
June 25, 2002
Assignees:
Genesis Research & Development Corporation Ltd., Fletcher Challenge Forests Ltd.
Abstract: Novel polynucleotides including partial and extended sequences, and open reading frames, are provided, together with probes and primers, DNA constructs comprising the polynucleotides, biological materials and organisms incorporating the polynucleotides, polypeptides expressed by the polynucleotides, and methods for using the polynucleotides and polypeptides.
Type:
Grant
Filed:
November 28, 2000
Date of Patent:
April 30, 2002
Assignee:
Genesis Research & Development Corporation Ltd.
Abstract: Novel isolated plant polynucleotide promoter sequences are provided, together with DNA constructs comprising such polynucleotides. Methods for using such constructs in modulating the transcription of DNA sequences of interest are also disclosed, together with transgenic plants comprising such constructs.
Type:
Grant
Filed:
March 25, 1999
Date of Patent:
April 30, 2002
Assignees:
Genesis Research & Development Corporation Ltd., Fletcher Challenge Forests Ltd.
Abstract: Novel isolated polynucleotides that encode polypeptides involved in plant cell signaling are provided, together with DNA constructs comprising such polynucleotides. Methods for using such constructs for the modulation of cell signaling in plants are also disclosed, together with transgenic plants comprising such constructs.
Type:
Grant
Filed:
January 12, 1999
Date of Patent:
March 19, 2002
Assignee:
Genesis Research & Development Corporation Ltd.
Inventors:
Timothy J. Strabala, Nicolaas J. Nieuwenhuizen
Abstract: Isolated polynucleotides encoding polypeptides expressed in mammalian fsn -/- lymph node stromal cells are provided, together with expression vectors and host cells comprising such isolated polynucleotides. In certain embodiments such polynucleotides encode members of the fibroblast growth factor receptor family. Methods for the use of such polynucleotides and polypeptides are also provided.
Type:
Grant
Filed:
August 26, 1999
Date of Patent:
June 5, 2001
Assignee:
Genesis Research & Development Corporation Ltd.
Abstract: Novel isolated DNA sequences associated with the lignin biosynthetic pathway are provided, together with DNA constructs including such sequences. Methods for the modulation of lignin content in plants are also disclosed, the methods comprising incorporating one or more of the inventive DNA sequences or a sequence complementary to an inventive DNA sequence into the genome of a plant.
Type:
Grant
Filed:
September 11, 1996
Date of Patent:
December 15, 1998
Assignees:
Genesis Research & Development Corporation, Ltd., Fletcher Challenge Forests Limited
Inventors:
Leonard N. Bloksberg, Ilkka Havukkala, Alastair Grierson