Patents Assigned to Genesoft, Inc.
  • Charged compounds comprising a nucleic acid binding moiety and uses therefor
    Patent number: 7301037
    Abstract: Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: November 27, 2007
    Assignee: Genesoft, Inc.
    Inventors: Yigong Ge, Matthew J. Taylor, Eldon E. Baird, Heinz E. Moser, Roland W. Burli
  • Charged compounds comprising a nucleic acid binding moiety and uses therefor
    Publication number: 20070105135
    Abstract: Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.
    Type: Application
    Filed: July 14, 2006
    Publication date: May 10, 2007
    Applicants: GeneSoft Pharmaceuticals, Inc., Genesoft, Inc.
    Inventors: Yigong Ge, Matthew Taylor, Eldon Baird, Heinz Moser, Roland Burli
  • BENZOTHIOPHENE COMPOUNDS HAVING ANTIINFECTIVE ACTIVITY
    Publication number: 20040142971
    Abstract: Benzothiophene compounds such as 1
    Type: Application
    Filed: June 6, 2002
    Publication date: July 22, 2004
    Applicant: GeneSoft, Inc.
    Inventors: Roland W. Burli, Eldon E. Baird, Matthew J. Taylor, Jacob A. Kaizerman, Wenhao Hu
  • Antipathogenic benzamide compounds
    Publication number: 20030236198
    Abstract: Antipathogenic benzamide compounds having the formula 1
    Type: Application
    Filed: June 6, 2002
    Publication date: December 25, 2003
    Applicant: GeneSoft, Inc.
    Inventors: Roland W. Burli, Jacob A. Kaizerman, Peter Jones
  • Charged compounds comprising a nucleic acid binding moiety and uses therefor
    Publication number: 20030211508
    Abstract: Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.
    Type: Application
    Filed: October 22, 2002
    Publication date: November 13, 2003
    Applicant: Genesoft, Inc.
    Inventors: Yigong Ge, Matthew J. Taylor, Eldon E. Baird, Heinz E. Moser, Roland W. Burli
  • Methods of treating infection by drug resistant bacteria
    Publication number: 20030199516
    Abstract: Methods are provided for treating an infection by Gram-positive bacteria in a mammal, by administering to the mammal an effective amount of a compound that binds noncovalently in the minor groove of duplex DNA, the compound being identified by a number of DNA binding parameters and, in many instances, being a polyaromatic compound.
    Type: Application
    Filed: September 12, 2002
    Publication date: October 23, 2003
    Applicant: Genesoft, Inc.
    Inventors: Heinz E. Moser, Eldon E. Baird, Roland W. Burli, Yigong Ge, Sarah White
  • Aryl-benzimidazole compounds having antiinfective activity
    Publication number: 20030191168
    Abstract: Aryl-benzimidazole compounds according to the formula 1
    Type: Application
    Filed: June 6, 2002
    Publication date: October 9, 2003
    Applicant: GeneSoft, Inc.
    Inventors: Dustin L. McMinn, Roland W. Burli, Jacob Kaizerman, Eldon E. Baird, Matthew J. Taylor
  • Halogen-substitued thienyl compounds
    Publication number: 20030130198
    Abstract: Halogen substituted thienyl compounds exhibit potential as nucleic acid (especially double stranded DNA) binders and as antibiotic compounds.
    Type: Application
    Filed: April 24, 2002
    Publication date: July 10, 2003
    Applicant: GeneSoft, Inc.
    Inventors: Yigong Ge, Matthew J. Taylor, Eldon E. Baird, Roland W. Burli, Jacob A. Kaizerman, Amanda E. Martin, Brie Cadman
  • Isoquinoline compounds having antiinfective activity
    Publication number: 20030083268
    Abstract: Isoquinoline compounds having the formula 1
    Type: Application
    Filed: June 6, 2002
    Publication date: May 1, 2003
    Applicant: GeneSoft, Inc.
    Inventors: Roland W. Burli, Peter Jones, Jacob A. Kaizerman, Wenhao Hu
  • Charged compounds comprising a nucleic acid binding moiety and uses therefor
    Patent number: 6555693
    Abstract: Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: April 29, 2003
    Assignee: Genesoft, Inc.
    Inventors: Yigong Ge, Matthew J. Taylor, Eldon E. Baird, Heinz E. Moser, Roland W. Bürli
  • Complex formation between dsDNA and pyrrole imidazole polyamides
    Patent number: 6143901
    Abstract: Methods and compositions are provided for forming complexes between dsDNA and oligomers of heterocycles, aliphatic amino acids, particularly omega-amino acids, and a polar end group. By appropriate choice of target sequences and composition of the oligomers, complexes are obtained with low dissociation constants. The formation of complexes can be used for identification of specific dsDNA sequences, for inhibiting gene transcription, and as a therapeutic for inhibiting proliferation of undesired cells or expression of undesired genes.
    Type: Grant
    Filed: April 21, 1997
    Date of Patent: November 7, 2000
    Assignee: Genesoft, Inc.
    Inventor: Peter B. Dervan