Abstract: A nucleic acid formulation for use in gene delivery comprising a nucleic acid and an anionic polymer is disclosed. Examples of the anionic polymer includes anionic amino acid polymer or poly-amino acid (such as poly-L-glutamic acid, poly-D-glutamic acid, poly-L-aspartic acid, poly-D-aspartic acid), poly-acrylic acid, polynucleotides, poly galacturonic acid, and poly vinyl sulfate.
Type:
Grant
Filed:
November 20, 2006
Date of Patent:
February 17, 2009
Assignee:
Genetronics Biomedical Corporation
Inventors:
Jason G Fewell, Fiona MacLaughlin, Louis C Smith, Francois Nicol, Alain Rolland
Abstract: A nucleic acid formulation for use in gene delivery comprising a nucleic acid and an anionic polymer is disclosed. Examples of the anionic polymer includes aniionic amino acid polymer or poly-amino acid (such as poly-L-glutamic acid, poly-D-glutamic acid, poly-L-aspartic acid, poly-D-aspartic acid), poly-acrylic acid, polynucleotides, poly galacturonic acid, and poly vinyl sulfate.
Type:
Grant
Filed:
September 3, 2002
Date of Patent:
February 6, 2007
Assignee:
Genetronics Biomedical Corporation
Inventors:
Jason Fewell, Fiona MacLaughlin, Louis C. Smith, Francois Nicol, Alain Rolland